Integrative sleep management: from molecular pathways to conventional and herbal treatments

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Язык: Английский

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Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease: Facts and Perspectives

COPD Journal of Chronic Obstructive Pulmonary Disease, Год журнала: 2021, Номер 18(6), С. 700 - 712

Опубликована: Окт. 1, 2021

The co-occurrence of obstructive sleep apnea (OSA) and chronic pulmonary disease (COPD) in the same patient, named overlap syndrome (OS), was first described 1985. Although American Thoracic Society underlined limited knowledge OS, stated research priorities for this condition, recommended a "screening" strategy to identify OSA COPD patients with stable hypercapnia, studies on OS remain scarce. This review aims summarize current perspectives related patients. prevalence is 1.0–3.6% general population, 3–66% patients, 7–55% may have worse quality than those or alone. Scoring hypopneas be difficult patients; desaturation episodes origins these namely upper airway obstruction, hypoventilation during paradoxical sleep, ventilation/perfusion mismatches, obesity. apnea–hypopnea index similar Desaturations greater more prolonged Low body mass index, hyperinflation, less collapsible airways reduce risk factor hypertension Whether increases mortality morbidity risks compared alone remains confirmed. No guidelines currently recommend specific approaches treatment COPD.

Язык: Английский

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Neurological and Psychiatric Comorbidities in Chronic Obstructive Pulmonary Disease

International Journal of COPD, Год журнала: 2021, Номер Volume 16, С. 553 - 562

Опубликована: Март 1, 2021

Background and Purpose: Chronic obstructive pulmonary disease (COPD) is often accompanied by different neurological psychiatric comorbidities. The purpose of this study was to examine which them are the most frequent explore whether their manifestation can be explained underlying latent variables. Methods: Data about patients with COPD comorbidities were extracted from an electronic database National Health Insurance Fund Lithuania for period between January 1, 2012, June 30, 2014. Exploratory factor analysis (EFA) used investigate comorbidity patterns. Results: A sample 4834 obtained database, 3338 (69.1%) who male. nerve, nerve root plexus disorders (n=1439, 29.8%), sleep (n=666, 13.8%), transient ischemic attack (n=545, 11.3%), depression (n=364, 7.5%) stroke (n=349, 7.2%). prevalence stroke, attack, Parkinson's disease, dementia increased age. One variable outlined during EFA grouped disorders, namely epilepsy, disease. second encompassed depression, anxiety, somatoform disorders. While similar patterns emerged in data male patients, no clear profiles among women obtained. Conclusion: Our provides novel insights into outlining association cerebrovascular, neurodegenerative Future studies could substantiate discrete pathological mechanism that underlie these groups. Keywords: chronic comorbidities, analysis, impairment,

Язык: Английский

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Association between cognitive declines and disability in activities of daily living in older adults with COPD: evidence from the China health and retirement longitudinal study

BMJ Open, Год журнала: 2020, Номер 10(10), С. e040098 - e040098

Опубликована: Окт. 1, 2020

Objectives This study aimed to investigate the relationship between disability and domain-specific cognitive function in older adults with chronic obstructive pulmonary disease (COPD). Design Cross-sectional analyses combined retrospective longitudinal analyses. Setting We included 450 communities China. Participants In this study, 1022 (mean age: 68.6±6.3; 612 males) 152 67.0±5.2; 83 COPD from China Health Retirement Longitudinal Study were a cross-sectional multivariate linear regression analysis logistic analysis, respectively. Outcome measures Disability was determined by difficulty or inability complete 1 of 12 activity items basic activities daily living (ADL) instrumental ADL. The dimensions episodic memory, attention/numerical ability, orientation time, visuospatial ability assessed via immediate/delayed recall task, serial sevens naming current date pentagon-figure-drawing tasks, Results Of respondents at wave-4, 48.5% had ADL disability. Declines global (β (95% CI)=−0.627 (−1.214 –0.040)), time CI)=−0.207 (−0.364 –0.050)) CI)=−0.068 (−0.127 –0.009)) significantly associated presence disability, when demographic health-related variables adjusted. participants without wave-2, 61 (40.1 %) developed over 2-year follow-up. Relative decline tine, those condition greater odds incidence increased factor about 1.46 Conclusions COPD, are vulnerable Prevention might help prevent people COPD.

Язык: Английский

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The CT pulmonary vascular parameters and disease severity in COPD patients on acute exacerbation: a correlation analysis

BMC Pulmonary Medicine, Год журнала: 2021, Номер 21(1)

Опубликована: Янв. 20, 2021

Abstract Background It is necessary to analyze the CT pulmonary vascular parameters and disease severity in chronic obstructive (COPD) patients provide evidence support for management of COPD. Methods COPD on acute exacerbation admitted our hospital from January 2019 March 2020 was selected. The characteristics ratio cross-sectional area (CSA) small vessels total lung field, artery aorta (PA/A) diameter with were analyzed. Results A 128 included. There significant differences duration COPD, smoking history, PaO 2 , PaCO pH, FEV1, FVC FEV1/FVC among different (all p < 0.05). smoking, CSA PA/A correlated Both CSA, post BD FEV1 cutoff value diagnosis severe 0.61 0.87 respectively, AUC 0.724 0.782 respectively. Conclusions Patients ≤ ≥ may have higher risks more studies are needed future further elucidate

Язык: Английский

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Clinical impact of routine sleep assessment by peripheral arterial tonometry in patients with COPD

ERJ Open Research, Год журнала: 2023, Номер 9(2), С. 00458 - 2022

Опубликована: Фев. 2, 2023

Background Coexisting obstructive sleep apnoea (OSA) in patients with COPD, defined as overlap syndrome (OVS), is prevalent and underdiagnosed. Routine assessment of OSA not common practice COPD care. Our study assessed the clinical impact by peripheral arterial tonometry (PAT) patients. Methods 105 (mean age 68.1±9 years, body mass index (BMI) 28.3±6.0 kg·m −2 , 44% males, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I to IV 2%, 40%, 42% 16%, respectively) underwent at an outpatient clinic including anthropometrics, blood gas (ABG) spirometry this cohort study. PAT-based studies were performed. Predictors OVS ABG determined. Rapid eye movement (REM) sleep-related (REM-OSA) was analysed OVS. Results 49 (47%) suffered from moderate severe (OVS group, mean apnoea–hypopnoea 30.8±18 events·h −1 REM-oxygen desaturation (REM-ODI) 26.9±17 ). more males compared females (59% 37%, p=0.029, respectively). Age (70.1±8 versus 66.3±10 years), BMI (30.0±6 26.4±7 ) hypertension prevalence (71% 45%) elevated (all p<0.03, respectively), while deep (12.7±7% 15.4±6%, p=0.029) overnight oxygenation (90.6±3% 92.3±2%, p=0.003) lower alone. REM-ODI independently associated daytime carbon dioxide tension ( P aCO 2 (β=0.022, p<0.001). REM-OSA atrial fibrillation no (25% 3%, p=0.022). Conclusions highly prevalent, specifically obese males. REM-related showed strong association cardiovascular disease. PAT feasible COPD.

Язык: Английский

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Effects of non-invasive ventilation on sleep in chronic hypercapnic respiratory failure

Thorax, Год журнала: 2023, Номер 79(3), С. 281 - 288

Опубликована: Ноя. 18, 2023

Chronic respiratory disease can exacerbate the normal physiological changes in ventilation observed healthy individuals during sleep, leading to sleep-disordered breathing, nocturnal hypoventilation, sleep disruption and chronic failure. Therefore, patients with obesity, slowly rapidly progressive neuromuscular obstructive airways report poor quality. Non-invasive (NIV) is a complex intervention used treat breathing hypoventilation overnight studies demonstrating improvement clinical trials improved outcomes for patients. However, impact on subjective objective quality dependent tools measure patient population. As home NIV becomes more commonly used, there need conduct focused quality, relationship between health-related of life, all groups, order allow clinician provide clear patient-centred information.

Язык: Английский

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Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease

Heliyon, Год журнала: 2024, Номер 10(13), С. e33745 - e33745

Опубликована: Июль 1, 2024

Aim and objectivesThis study aimed to identify symptom cluster (SC) patterns change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), the correlation SCs laboratory imaging indicators, intrinsic association prognostic outcomes burden.MethodSymptom information was collected using a digital evaluation scoring system at time admission, on third day after upon discharge. Laboratory examination data were compiled simultaneously. Exploratory factor analysis used AECOPD SCs. The number factors (clusters) determined by examining eigenvalues ≥1.0, 0.50 for loadings as minimum cut-off value. Spearman's explore link between well relationship severity symptoms different clusters, outcomes, burden.ResultsThis included 148 patients. Three identified: activity-nutrition SC, breath-sleep SC respiratory SC. Correlation indicated connection white blood cell count, serum sodium potassium levels, whereas correlated cells eosinophil counts, level, pleural effusion. Additionally, associated calcium magnesium partial pressure carbon dioxide, C-reactive protein (CRP) level. There positive hospitalization cost, both length cost.ConclusionPatients presented three that affected cost hospitalization. Concurrently, clusters related counts; sodium, potassium, calcium, levels; CRP level; dioxide; effusion, indicating each may share physiological mechanisms. An in-depth exploration pathogenesis intervention paths health problems is great significance promoting precision nursing.

Язык: Английский

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Ambient ultrafine particles exacerbate oxygen desaturation during sleep in patients with chronic obstructive pulmonary disease: New insights into the effect spectrum of ultrafine particles on susceptible populations

The Science of The Total Environment, Год журнала: 2024, Номер 947, С. 174519 - 174519

Опубликована: Июль 6, 2024

Язык: Английский

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The Effect of Symptom Clusters and Sleep Disorder on Quality of Life among Patients with Chronic Obstructive Pulmonary Disease

Journal of Healthcare Engineering, Год журнала: 2021, Номер 2021, С. 1 - 8

Опубликована: Авг. 31, 2021

Background. Symptoms (cough, dyspnea, fatigue, depression, and sleep disorder) in chronic obstructive pulmonary disease (COPD) are related to poor quality of life (QOL). Better understanding the symptom clusters (SCs) disorder COPD patients could help accelerate development symptom-management interventions. Objective. We aim explore effect on QOL with COPD. Methods. 223 stable from November 2019 2020 at Affiliated People’s Hospital Ningbo University China were included this cross-sectional survey. A demographic clinical characteristics questionnaire, Revised Memorial Symptom Assessment Scale (RMSAS), Pittsburgh Sleep Quality Index (PSQI), St George Respiratory Questionnaire for (SGRQ-C) completed by patients. Exploratory factor analysis was conducted extract SCs, logistic regression performed analyze risk factors affecting QOL. Results. Three extracted: respiratory functional cluster, emotional fatigue-sleep cluster. 70.4% participants sleepers. Subgroup showed that significantly different QOL, cluster compared normal sleep. In multiple regression, associated Conclusion. COPD, three explored. correlate features negatively affect Appropriate interventions expected inform future approaches management. Future studies needed test may be effective improving

Язык: Английский

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