Fundación Weber eBooks, Год журнала: 2023, Номер unknown
Опубликована: Янв. 1, 2023
Journal of Thoracic Disease, Год журнала: 2023, Номер 15(4), С. 2300 - 2313
Опубликована: Апрель 1, 2023
Background and Objective: Chronic cough is one of the commonest complaints requiring medical attention that significantly impacts on patient's quality life.In this review, we focus chronic prevalence, risk factors, health burden among general adult population based recent reports, which will be helpful for a better understanding global cough.Methods: A narrative search Medline was performed articles their lists references published using keywords "chronic cough", bronchitis", "epidemiology", "prevalence", "risk factor", "burden", "quality life", "adult" "general population".Key Contents Findings: Although there growing literature prevalence in from different countries, populations cannot directly compared because use varying definitions cough.Generally, higher Europe North America than Asia.Regarding factors cough, several have been identified, including age, smoking, asthma, allergic rhinitis, rhinosinusitis, whereas other imputed such as occupational exposure, air pollution, obesity, these remain inconclusive.Although usually not life-threatening, physical psychological impact obvious, leading to substantial healthcare resource utilization, especially elderly or those with comorbidities.Conclusions: common symptom can associated deterioration life increased burden.The identification co-morbidities help towards an improved management condition.There urgent need apply standard definition future research, so comparisons findings across made.
Язык: Английский
Процитировано
18
European Respiratory Journal, Год журнала: 2021, Номер 59(6), С. 2100725 - 2100725
Опубликована: Окт. 14, 2021
The purinoceptor subtype P2X3 has been shown to have significant involvement in the cough reflex; heterotrimer version of (P2X2/3) implicated taste disturbance. most advanced clinical candidate antagonist gefapixant low selectivity among receptors and induced disturbance, whereas newly developed sivopixant high towards P2X3versus P2X2/3.In a phase 2a, randomised, double-blind, placebo-controlled, crossover, multicentre study, adult patients with refractory or unexplained chronic received oral 150 mg placebo once daily for 2 weeks, followed by 2-3-week washout period, then crossed over weeks. Efficacy safety were evaluated.Of 31 randomised patients, 15 sivopixant-first group placebo-first completed study. After weeks treatment, placebo-adjusted ratios average hourly number coughs baseline during daytime (primary end-point) 24 h (secondary -31.6% (p=0.0546) -30.9% (p=0.0386), respectively. Sivopixant also improved health-related quality life. Treatment-related adverse events occurred 12.9% 3.2% administration, Mild disturbance two (6.5%) administration.Sivopixant reduced objective frequency life, incidence cough.
Язык: Английский
Процитировано
40
European Journal of Internal Medicine, Год журнала: 2020, Номер 81, С. 15 - 21
Опубликована: Сен. 19, 2020
Cough is a common respiratory symptom that considered to be chronic when it lasts more than eight weeks. When severe, cough may significantly impact an individual's quality of life, and such patients are frequently referred for specialist evaluation. Current international guidelines provide algorithms the management cough: in most cases, treatment underlying disease sufficient improve or resolve symptoms. Severe affect patients' life necessitate frequent referral evaluations. In this narrative review, we summarize non-pharmacologic pharmacologic adult with known cause persists after proper (chronic refractory cough, CRC) unknown patients. If even disease, if not attributable any cause, then symptomatic approach neuromodulators considered, gabapentin as first choice, opioids macrolides alternatives. Speech pathology and/or should discussed alternative options carefully taking into account risk/benefit. Novel promising drugs under investigation (e.g. P2×3 inhibitors), but additional studies needed field. can combined neuromodulator give enhanced response longer duration suggesting play key role CRC.
Язык: Английский
Процитировано
39
BMC Pulmonary Medicine, Год журнала: 2022, Номер 22(1)
Опубликована: Фев. 12, 2022
Abstract Background Individual studies have indicated variable prevalence for chronic cough, but thus far, there has been no systematic report on the of this condition. Methods In study, we performed a review and meta-analysis by searching databases including PubMed, Cochrane Library, Web Science, China National Knowledge Infrastructure, Chinese biomedical literature service system, Wanfang Database, VIP database, cough in published before December 28, 2020. A random effects model was used to calculate pooled estimates with 95% confidence interval [95%CI], weighted study size. Results Fifteen 141,114 community-based adults were included showing 6.22% (95% CI 5.03–7.41%). And 21 164,280 children included, presenting 7.67% 6.24–9.11%). subgroup meta-analyses, 4.38% 2.74–6.02%) southern 8.70% 6.52–10.88%) northern China. population, also higher than (northern vs. southern: 7.45% 5.50–9.41%, 7.86% 5.56–10.16%). Conclusions Our population-based provides relatively reliable data may help development global strategies management.
Язык: Английский
Процитировано
19
Sleep Health, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
World Allergy Organization Journal, Год журнала: 2022, Номер 15(5), С. 100649 - 100649
Опубликована: Май 1, 2022
BackgroundChronic cough management necessitates a clear integrated care pathway approach. Primary physicians initially encounter the majority of chronic patients, yet their role in proper can prove challenging due to limited access advanced diagnostic testing. A multidisciplinary approach involving otolaryngologists and chest physicians, allergists, gastroenterologists, among others, is central optimal diagnosis treatment conditions which underly or worsen cough. These include infectious inflammatory, upper lower airway pathologies, gastro-esophageal reflux. Despite wide armamentarium ancillary testing conducted care, such improve but seldom resolves it completely. This be partly data on tests (eg, spirometry, exhaled nitric oxide), as well classical pharmacotherapy specialties for Other important factors presence multiple concomitant trigger mechanisms neuronal complexity Subsequent by specialists aims at control refractory prior interventions includes cough-specific behavioral counseling with neuromodulators, others. Preliminary neuromodulators proof-of-concept manner are encouraging lack strong evidence efficacy safety.ObjectivesThe World Allergy Organization (WAO)/Allergic Rhinitis its Impact Asthma (ARIA) Joint Committee Chronic Cough reviewed recent literature primary, multidisciplinary, cough-specialty care. Knowledge gaps testing, neuromodulator pharmacotherapy, addition therapy were also analyzed.OutcomesThis third part WAO/ARIA consensus suggests algorithm an Insights into inherent limitations safety currently available antitussive recently recognized therapy, significantly standards patients
Язык: Английский
Процитировано
13
Allergy Asthma and Immunology Research, Год журнала: 2023, Номер 15(6), С. 795 - 795
Опубликована: Янв. 1, 2023
Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) unexplained (UCC). These led to initiation this study, which reported demographic characteristics, manifestations, long-term outcomes on a large series consecutive RCC/UCC patients, providing guideline-led real-world clinical experience.Retrospective baseline information was obtained from Clinical Research Database (January 2016 May 2021). At least 6 months after last clinic visit, included subjects were prospectively followed up.Three hundred sixty-nine RCC UCC patients (199 females, 53.9%) analyzed. The median duration 24.0 (12.0-72.0) months. Laryngeal symptoms in 95.9% patients. common triggers for coughing talking (74.9%), pungent odors (47.3%), eating (45.5%), cold air (42.8%). considered 38.2%, remainder 228 had UCC, with an equal sex distribution (P = 0.66). Among 141 RCCs, 90.8% (128) reflux cough, more responsive current treatments < 0.01). Although most test results between similar, commonly inappropriately treated Nineteen (7.7-41.1) final 31.2% still coughed persistently, while 68.8% improvement or remission. favorable treatment (including improvement, control, spontaneous remission) than Coughs long before initial visit 0.01), frequent urinary incontinence being sensitive "talking" 0.01) "cold air" less likely be solved.The only improve two-thirds indicators failure those air."
Язык: Английский
Процитировано
6
Heliyon, Год журнала: 2023, Номер 10(1), С. e23413 - e23413
Опубликована: Дек. 7, 2023
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants formed during the incomplete combustion of organic substances, such as coal and oil. PAHs exposure is known to increase incidence respiratory diseases; however, limited research has focused on their impact chronic cough. In this study, we utilized data from National Health Nutritional Examination Surveys (NHANES) 2003 2012. Chronic cough was defined 'coughing most days for three consecutive months or more'. Employing survey-weighted multivariate logistic regression models, identified positive associations between all six metabolites (1-NAP, 2-NAP, 3-FLU, 2-FLU, 1-PHE, 1-PYR) found in urine presence Furthermore, results restricted cubic spline modeling revealed a nonlinear relationship urinary levels 1-NAP, 1-PYR risk Co-exposure unveiled combined effects multiple exposures relative contributions each PAHs. Notably, co-exposure positively associated with an increased cough, where 2-FLU emerged primary contributor association. These findings were particularly pronounced individuals high cotinine (≥0.05 ng/mL). conclusion, study presents epidemiological evidence linking elevated Further prospective investigations warranted corroborate these findings.
Язык: Английский
Процитировано
4
Therapeutic Advances in Respiratory Disease, Год журнала: 2024, Номер 18
Опубликована: Янв. 1, 2024
Background: Sex-related disparities in the prevalence of chronic cough have been consistently reported globally, with varying male-to-female ratios. Objectives: This study aimed to evaluate sex-related differences by comparing correlations between cough-related symptoms males and females different age groups. Design: Adult patients who completed Leicester Cough Questionnaire (LCQ) were recruited from 16 respiratory centers. Methods: Correlation networks constructed based on Spearman’s correlation coefficients various The distinct relationships subgroups validated an independent cohort. Results: A total 255 enrolled this (male-to-female ratio, 1:1.71). following LCQ items highly correlated: embarrassment interference daily work, anxiety, overall life enjoyment/feeling being fed up, work enjoyment, enjoyment feeling up annoyance partner/family/friends. patterns these varied ages. strongest interrelationship was observed male aged >50 years old, which similar those validation Conclusion: vary significantly according sex. Understanding mechanisms underlying development may facilitate sex- age-specific strategies for cough.
Язык: Английский
Процитировано
1
Medicine, Год журнала: 2023, Номер 102(20), С. e33779 - e33779
Опубликована: Май 18, 2023
Gastroesophageal reflux-related chronic cough (GERC), is one common type of cough. Drug treatment effective for some GERC patients. But, there refractory (rGERC). For rGERC, fundoplication may be the only method. However, were very few studies about laparoscopic in treating and cure rate rGERC was unknown. So a question, what rGERC? To solve this we performed meta-analysis.The PRISMA strategy Cochrane collaboration method used study. Our study registered with PROSPERO (ID: CRD42021251072). We searched PubMed, Medline, Web Science, databases from 1990 to December 2022. The meta-analysis Review Manager 5.4 Stata 14.After selection exclusion, 8 articles out 672 included. showed 62% (95% confidence interval: 53-71%), no deaths 503 There significant heterogeneity or bias meta-analysis.In terms safety, quite reliable offered by skilled surgeons. In rate, could completely heal two-thirds patients; however, are still patients who can not cured fundoplication.
Язык: Английский
Процитировано
3