Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1386 - 1386

Опубликована: Ноя. 14, 2024

Background: The gut microbiota constitutes a complex microorganism community that harbors bacteria, viruses, fungi, protozoa, and archaea. human bacterial has been extensively proven to participate in metabolism, immunity, nutrient absorption. Its imbalance, namely “dysbiosis”, linked disordered metabolism. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the features deranged metabolism leading cause cirrhosis hepatocellular carcinoma. Thus, there pathophysiological link between dysbiosis MASLD. Aims Methods: We aimed review literature data on composition its MASLD describe concept “gut–liver axis”. Moreover, we reviewed approaches for modulation treatment. Results: There consolidated evidence particular associated with stages. model explaining relationship bidirectional organization, physiopathology Oxidative stress keystones pathophysiology fibrosis generation. promising efficacy pre- probiotics reversing patients, therapeutic effects. Few yet encouraging fecal transplantation (FMT) are available literature. Conclusions: characteristic key target reversal treatment via diet, pre/probiotics, FMT remains treatment, prevention, reversal.

Язык: Английский

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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 7, 2025

Introduction Thiamine (vitamin B1) in the gut is crucial for maintaining intestinal homeostasis and host health. Our previous study identified significantly lower levels of fecal thiamine individuals with obesity; however, its potential mechanisms alleviating obesity induced by a high-fat high-fructose diet (HFFD) remain unclear. Therefore, present study, effects high-dose supplementation on HFFD-induced microbiota dysbiosis were investigated. Methods HFFD-fed mice supplemented eight weeks. Biochemical analysis histological conducted to assess phenotypic changes. Fecal 16S rRNA gene sequencing was performed analyze alterations microbiota. Results The results showed that weeks could alleviate symptoms improve epithelial barrier dysfunction enhancing tight junction function. Furthermore, oral administration also regulated reshaping structure composition microbiota, such as increasing relative abundance Actinobacteria Bifidobacterium pseudolongum , reducing Proteobacteria Ruminococcus gnavus accompanied decreased level gut-derived endotoxin. Finally, significant correlations found between obesity-related phenotypes through correlation analysis. Conclusion findings suggest mechanism which alleviated might involve restoring barrier, thereby ameliorating microbiota-related endotoxemia.

Язык: Английский

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AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES

Archives of Gerontology and Geriatrics Plus, Год журнала: 2025, Номер unknown, С. 100142 - 100142

Опубликована: Март 1, 2025

Язык: Английский

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Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression

World Journal of Hepatology, Год журнала: 2025, Номер 17(3)

Опубликована: Март 25, 2025

In the current era, metabolic dysfunction-associated steatotic liver disease (MASLD) has gradually developed into a major type of chronic that is widespread globally. Numerous studies have shown gut microbiota plays crucial and indispensable role in progression MASLD. Currently, become one important entry points for research this disease. Therefore, aim review to elaborate on further associations between MASLD, including changes differences healthy diseased liver. Meanwhile, considering fatty steatohepatitis are abnormal pathological states development exhibits different degrees fibrosis (such as mild severe fibrosis) during progression, we also conduct comparison these use them markers progression. It reveals production action mechanisms short-chain acids bile brought about by microbiota, impact lipopolysaccharide from Gram-negative bacteria addition, regulation inhibition related factors probiotics (including new-generation probiotics) will be explored, which help monitor patients with compositions future carry out personalized targeted therapies microbiota. This achieve progress preventing combating

Язык: Английский

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Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights

Journal of Bacteriology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

ABSTRACT Obesity, characterized by excessive fat accumulation, stems from an imbalance between energy intake and expenditure, with the gut microbiota playing a crucial role. This review highlights how influences metabolic pathways, inflammation, adipose tissue regulation in obesity. Specific bacteria metabolites, such as lipopolysaccharides (LPS) short-chain fatty acids (SCFAs), modulate permeability, harvest, impacting obesity development. Certain bacteria, including Clostridium XIVb , Dorea spp., Enterobacter cloacae Collinsella aerofaciens promote increasing inflammatory response through LPS translocation into bloodstream. Conversely, beneficial like Akkermansia muciniphila Lactobacillus Bifidobacterium spp. enhance barrier integrity, regulate SCFA production, fasting-induced factor, which collectively support health reducing storage inflammation. Metabolites SCFAs (acetate, propionate, butyrate) interact G-protein coupled receptors to lipid metabolism browning of white (WAT), thus enhancing thermogenesis expenditure. However, contributes insulin resistance highlighting dual roles these microbial metabolites both supporting disrupting function. Therapeutic interventions targeting microbiota, promoting WAT activating brown (BAT), hold promise for management. personalized approaches are necessary due individual microbiome variability. Further research is essential translate insights microbiota-based clinical therapies.

Язык: Английский

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Unraveling Metabolic Syndrome in Youth: The Obesity Epidemic’s Hidden Complication

Children, Год журнала: 2025, Номер 12(4), С. 482 - 482

Опубликована: Апрель 8, 2025

One of the metabolic complications obesity is known as Metabolic Syndrome (MetS). This narrative review aims to synthesize current research on MetS in young populations, identify knowledge gaps, and guide future studies funding priorities. It provides evidence-based insights into screening, diagnosis, treatment, offering practical guidance for healthcare professionals. A comprehensive search literature was conducted relevant PubMed Google Academic electronic database. The performed using a combination "obesity", "complications", "metabolic syndrome", "children", "adolescents" keywords. Studies were selected based predefined inclusion exclusion criteria ensure relevance methodological rigor. lack universally accepted diagnostic children has led inconsistencies its definition across medical literature. Irrespective chosen approach, prevalence adolescents exhibited concurrent rise with increasing rates this age group. pathophysiology remains incompletely understood, ongoing discussions interplay genetic, epigenetic, environmental, dietary, lifestyle factors. Screening recommended overweight obese children. Establishing global, consensus-driven that account ethnicity, gender, would enhance accuracy treatment approaches. prevention excessive weight among stands paramount objective within modern society's system. Considering complexity disease team must be multidisciplinary.

Язык: Английский

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Causal relationship between gut microbiota and metabolic syndrome: A bidirectional Mendelian randomization study

Medicine, Год журнала: 2025, Номер 104(17), С. e42179 - e42179

Опубликована: Апрель 25, 2025

Metabolic syndromes (MetS) are complex metabolic disorders, the pathogenesis of which has not been fully elucidated. In recent years, association between gut microbiota and MetS attracted widespread attention, but causal relationship remains unclear. We performed a 2-sample Mendelian randomization analysis (MR) to examine whether is causally related its components find basis for potential diagnostic or intervention approaches MetS. utilized summary statistics from whole-genome analyses MiBioGen consortium obtained MetS-related data UK Biobank, IEU Open GWAS project, The Meta-Analyses Glucose Insulin-related traits Consortium (MAGIC). MR were using inverse variance weighted, MR-Egger, weighted median. Sensitivity conducted verify robustness results. Among 211 microbiota, we identified 8 that significantly associated with risk Specifically, Lachnospiraceae (family), Veillonellaceae Victivallaceae Odoribacter (genus), Olsenella (genus) may increase MetS, while Bifidobacteriaceae Ruminococcaceae UCG-010 Actinobacteria (phylum) decrease Additionally, discovered multiple various such as BMI, hypertension, blood lipid levels. This study first use methods reveal specific providing new perspective understanding offering important evidence development microbiota-based prevention treatment strategies

Язык: Английский

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Gut microbiome and metabolic dysfunction-associated steatotic liver disease: Pathogenic role and potential for therapeutics

Best Practice & Research Clinical Gastroenterology, Год журнала: 2024, Номер 72, С. 101924 - 101924

Опубликована: Май 9, 2024

Язык: Английский

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Inflammatory Bowel Diseases and the Efficacy of Probiotics as Functional Foods

Frontiers in Bioscience-Elite, Год журнала: 2024, Номер 16(2)

Опубликована: Май 8, 2024

Adverse intestinal microbiome profiles described as a dysbiotic gut are complicit etiological operative factor that can progress and maintain inflammatory sequelae in the intestines. The disruption of ensues with dysbiosis is, for example, posited by decreases alpha-diversity microbiome, which is characterized significant reductions abundance bacterial members from Bacteroidetes Firmicutes phyla. Proteobacteria have often been recognized microbial signatures disease. For this happens observed increases phyla Gammaproteobacteria, such adherent-invasive Escherichia coli strain, has significantly linked maintaining bowel diseases. Research on administration probiotics, identified gut-functional foods, demonstrated safety, tolerability, efficacy issues treating diseases (IBDs). In narrative review, we explore probiotics IBDs strain- dose-specific characteristics association multi-strain administration.

Язык: Английский

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Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

European Journal of Internal Medicine, Год журнала: 2024, Номер 128, С. 10 - 19

Опубликована: Июль 27, 2024

Язык: Английский

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