Assessment of Anticancer Properties of Thai Plants

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 122 - 164

Опубликована: Март 11, 2024

Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The categorizes these plants based active components reviews both laboratory animal studies to understand underlying mechanisms involved in inhibiting cell growth, inducing death, preventing tumor blood vessel formation. Clinical trials supporting findings are also highlighted. Given improve or innovate treatments, present encouraging prospects. However, further research is essential confirm safety approaches. These suggest that could lead development innovative drugs, signaling advancements therapy.

Язык: Английский

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A Review of Click Chemistry in the Synthesis of Organophosphorus Triazoles and Their Biological Activities

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 286, С. 117270 - 117270

Опубликована: Янв. 13, 2025

Organophosphorus compounds, characterized by the incorporation of phosphorus into organic molecules, play a critical role in various fields such as medicine, agriculture, and industry. Their unique electronic properties versatility make them essential developing therapeutic agents, pesticides, materials. One prominent class organophosphorus compounds is heterocycles, which combine benefits both cyclic structures. Triazoles, nitrogen-containing heterocyclic are particularly notable for their broad biological activities, including anticancer, antiviral, antibacterial, antioxidant effects. Traditional methods synthesizing triazoles often encounter challenges low yields non-selective products, whereas click chemistry provides more efficient reliable alternative. The copper-catalyzed azide-alkyne [3 + 2] cycloaddition, cornerstone chemistry, allows rapid selective formation under mild conditions. When functionalized with groups, not only retain but enhance improving potency, selectivity, stability. This review covers synthesis organophosphorus-functionalized via explores molecular structure, coordination these compounds. behavior interactions derivatives metal ions also addressed, significantly influence chemical reactivity, stability, bioactivity.

Язык: Английский

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Exploring the Impact of Click Chemistry on Carbohydrate Derivatives and their Biological Properties

Asian Journal of Chemistry, Год журнала: 2025, Номер 37(4), С. 745 - 757

Опубликована: Март 29, 2025

The application of click chemistry in the synthesis intricate carbohydrate derivatives has revolutionized domains chemical biology and synthetic chemistry. This review examines function chemistry, namely copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), effectively altering structures producing practical glycoconjugates. Carbohydrates are essential several biological functions, such as cellular recognition immunological responses, however, their complicated structure makes production difficult. Click provides an optimal answer to these issues due its simplicity, high yields bioorthogonality. methodology been extensively used advancement glycoproteins, glycodendrimers glycopeptides, which play a crucial role fields drug discovery, vaccine development diagnostics. In addition, facilitated biodegradable polymers glycomacromolecules that have potential be materials science, for sustainable smart technology. flexibility accuracy CuAAC carbohydrate-based new opportunities investigation, stimulating advancements both biomedicine industrial applications. evaluation also emphasizes capacity expedite multifunctional therapeutic drugs target ailments like cancer.

Язык: Английский

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Discovery, synthesis, and anti-cancer evaluation of 10-Pterostilbene methylamine hydrochloride derivatives as potential COX-2 and Topo I dual inhibitors

Journal of Molecular Structure, Год журнала: 2024, Номер 1311, С. 138363 - 138363

Опубликована: Апрель 20, 2024

Язык: Английский

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Click-chemistry-inspired synthesis of new series of 1,2,3-triazole fused chromene with glucose triazole conjugates: Antibacterial activity assessment with molecular docking evaluation

Carbohydrate Research, Год журнала: 2024, Номер 543, С. 109222 - 109222

Опубликована: Июль 30, 2024

Язык: Английский

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(Hetero)Aryl Fluorosulfates (ArOSO₂F): Good Coupling Partners in Transition‐metal‐catalyzed Reactions

Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(23), С. 4068 - 4085

Опубликована: Окт. 26, 2023

Abstract (Hetero)Aryl fluorosulfates (ArOSO 2 F/ArOFs) emerged as a versatile synthon in “click chemistry,” attracting the interest of chemists owing to their extensive applications fields such biology, medicine, materials, and polymers. Readily prepared from widely available phenolic compounds nature, serve economical, efficient, environmentally friendly alternative trifluoromethane sulfonates. In recent years, have attracted research attention emerging electrophilic reagents transition‐metal‐catalyzed coupling reactions. The development broad range reactions will considerably expand interdisciplinary fields. This review summarized synthesis methods for instances partners various

Язык: Английский

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A CuSO4/Bicinchoninic acid/Reducing sugar based stable and non-ROS catalyst system for the CuAAC reaction in bioanalysis

Bioorganic Chemistry, Год журнала: 2024, Номер 150, С. 107557 - 107557

Опубликована: Июнь 12, 2024

Язык: Английский

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“Polymer blends innovation: Advancement in novel drug delivery”

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Авг. 7, 2024

The integration of polymers and modified in diverse drug delivery systems, including implants, gene delivery, nano-based approaches, has significantly advanced therapeutic interventions. Implants-based utilizing bio-degradable like poly(lactic-co-glycolic acid)(PLGA) polycaprolactone(PCL), demonstrates efficacy sustained release, enhancing patient compliance. Polymers synergize with efficiently targeting genetic material overcoming therapy challenges. In polymer-based nanoparticles (micelles, dendrimers, nanogels) provide precise control over release kinetics, improved uptake, enhanced bioavailability. This review underscores polymers' pivotal role developing improving efficacy, reducing systemic toxicity.

Язык: Английский

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New Carboxytriazolyl Amphiphilic Derivatives of Calix[4]arenes: Aggregation and Use in CuAAC Catalysis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16663 - 16663

Опубликована: Ноя. 23, 2023

This work focuses on the synthesis of a new series amphiphilic derivatives calix[4]arenes for copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The aggregation properties synthesized were studied using various techniques (fluorescence spectroscopy, nanoparticle tracking analysis, and dynamic light scattering). Increasing length alkyl substituent led to stronger hydrophobic interactions, which increased polydispersity in solution. zwitterionic nature was established different types dyes (Eosin Y anionic structures Rhodamine 6G cationic structures). used as organic stabilizers CuI. catalytic efficiency CuI-calix[4]arene compared with that phase transfer catalyst tetrabutylammonium bromide (TBAB) surfactant sodium dodecyl sulfate (SDS). For all calixarenes, selectivity CuAAC reaction higher than observed when TBAB SDS estimated.

Язык: Английский

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Convergent Synthesis of OH-Terminated Water-Soluble Dendrimers Based on Imidazole-4,5-dipropargyl-diamide

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(12), С. 3208 - 3216

Опубликована: Дек. 1, 2024

Язык: Английский

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