Food Science & Nutrition, Год журнала: 2024, Номер 13(1)
Опубликована: Дек. 26, 2024
In 2019, diabetes mellitus affected 9.3% of the global population and accounted for one in nine adult deaths. Plant-based antioxidants neutralize harmful free radicals, mitigate oxidative stress, significantly prevent its complications. This study evaluated vitro antioxidant, alpha-amylase inhibitory, vivo oral hypoglycemic,
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер unknown, С. 100030 - 100030
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Natural Product Communications, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 1, 2025
Background Crateva unilocularis, Millettia extensa, and Plumbago zeylanica are commonly used traditional medicinal plants in Nepal for treating various skin ailments. Objectives The ethanol extracts of these were analyzed qualitative quantitative phytochemical content, antioxidant potential, anti-tyrosinase activity. Methods Folin-Ciocalteu technique was to measure the total phenolic aluminum chloride method assess flavonoid content.In vitro activity evaluated via 2,2- diphenyl-1-picrylhyrazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H 2 O ) assays. A mushroom tyrosinase inhibition assay employed Molecular docking performed using enzyme (PDB ID: 2Y9X) five selected phytoconstituents extensa. Results ethanolic extract extensa leaves exhibited high concentrations compound (273.85 ± 4.05 mg GAE/g dry weight) flavonoids (1787.35 0.22 QE/g weight). roots showed highest levels DPPH NO radical-scavenging activities, with percentages 95.83% 43.83%, respectively. Similarly, stem bark unilocularis notable H radical scavenging (67.81%). root demonstrated most potent (99.31 0.16), comparable standard drug Kojic acid (99.56 0.08). corroborates activity, isoauriculatin auriculatin demonstrating binding affinities −9.9 −9.7 kcal/mol, respectively, compared (−5.6 kcal/mol). Conclusion These findings highlight significant inhibitory potential bark, suggesting further exploration its cosmetic application safety evaluation.
Язык: Английский
Процитировано
0
Journal of Clinical Laboratory Analysis, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
ABSTRACT Objectives The rise in carbapenem‐resistant Enterobacterales (CRE) has reinforced the global quest for developing effective therapeutics. Traditional drug discovery approaches have been inadequate overcoming this challenge due to their resource and time constraints. Methods English literature was searched by structured queries related our review between January 1, 2020, December 31, 2024. Results key resistance mechanisms CRE, such as enzymatic hydrolysis, decreased permeability, efflux pump overexpression, examined review. Computational technologies become pivotal discovering novel antimicrobial agents with improved accuracy efficiency. Besides this, highlights advances structure‐ ligand‐based identifying potential drugs against CRE. Recent studies demonstrating use of silico techniques develop targeted CRE also explored. Moreover, underscores significance integrating both vitro counter Enterobacterales, supported latest studies. However, these promising computational a few major drawbacks, lack standardized parameterization, potentially false positives, complexity clinical translations. regulatory barriers restrict progress new antimicrobials market approval. Conclusion inhibitor is gaining popularity, it can be expedited refining them reliable validation. innovative hybrid need hour tackle mitigate threat resistance.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(22), С. e40300 - e40300
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
Journal of Chemistry, Год журнала: 2024, Номер 2024(1)
Опубликована: Янв. 1, 2024
Objective . The red rhizome of Angiopteris helferiana has been used widely to treat muscle fatigue, bone pain, and skin infection in Nepal. However, scientific evidence for its bioactive compounds their bioactivities was lacking till January, 2024. Therefore, we investigated validate advance the further use development. Methods Column chromatography, including MCI gel CHP20P, Sephadex LH‐20, ODS, Silica gel, isolation from 70% methanol extract A. rhizomes. isolated were evaluated TLC‐based antioxidant antibacterial activity against Staphylococcus aureus , Klebsiella pneumonia Escherichia coli Pseudomonas aeruginosa by adopting agar well diffusion protocol. Furthermore, silico molecular docking penicillin binding protein E. (PBP1b, PBP2, PBP3 TPd) ADME toxicity predicted. Results Discussion Angiopteroside ( 1 ) osmundalactone 2 first time rhizomes structure elucidated on basis spectroscopic H‐, 13 C‐, C/DEPT‐NMR) spectrometric (LC MS/ESI IR) analyses comparison with reported literature. Both inactive towards DPPH scavenging activity. Compound showed poor inhibitory coli, inhibition zone range 2–7 mm. both found be resistant S. K P Based forecasting, compound revealed good affinity PBP1b (−6.5 kcal/mol), PBP2 (−5.8 kcal/mol) TPd (−6.1 compared positive control meropenem (−6.6 (−6.9 kcal/mol). Similarly, weak preference (−4.3 (−4.4 PBP (−4.5 Compounds predicted safe terms hepatotoxicity, cytotoxicity, mutagenicity, carcinogenicity, a potential induce nephrotoxicity similar that meropenem. Conclusion This study successfully isolates two lactones properties inspires researcher research, development, formulation.
Язык: Английский
Процитировано
1
Food Science & Nutrition, Год журнала: 2024, Номер 13(1)
Опубликована: Дек. 26, 2024
In 2019, diabetes mellitus affected 9.3% of the global population and accounted for one in nine adult deaths. Plant-based antioxidants neutralize harmful free radicals, mitigate oxidative stress, significantly prevent its complications. This study evaluated vitro antioxidant, alpha-amylase inhibitory, vivo oral hypoglycemic,
Язык: Английский
Процитировано
1