Molecules,
Год журнала:
2022,
Номер
27(3), С. 901 - 901
Опубликована: Янв. 28, 2022
Alzheimer’s
disease
(AD)
is
a
progressive,
neurodegenerative
disorder
that
currently
has
reached
epidemic
proportions
among
elderly
populations
around
the
world.
In
China,
available
traditional
Chinese
medicines
(TCMs)
organically
combine
functional
foods
with
medicinal
values
are
named
“Medicine
Food
Homology
(MFH)”.
this
review,
we
focused
on
MFH
varieties
for
their
features,
substance
bases,
clinical
uses,
and
mechanisms
of
action
(MOAs)
AD
prevention
treatment.
We
consider
antiAD
active
constituents
from
species,
effects
in
vitro/in
vivo
models,
drug
targets
signal
pathways
by
summing
up
literature
via
systematic
electronic
search
(SciFinder,
PubMed,
Web
Science).
paper,
several
plant
sources
discussed
detail
models
methods,
to
MOAs.
found
most
exert
neuroprotective
ameliorate
cognitive
impairments
inhibiting
neuropathological
signs
(Aβ-induced
toxicity,
amyloid
precursor
protein,
phosphorylated
Tau
immunoreactivity),
including
anti-inflammation,
antioxidative
stress,
antiautophagy,
antiapoptosis,
etc.
Indeed,
some
substances
related
phytochemicals
have
broad
spectrum
activities,
so
they
superior
simple
single-target
drugs
treating
chronic
diseases.
This
review
can
provide
significant
guidance
people’s
healthy
lifestyles
development
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(3), С. 479 - 493
Опубликована: Март 3, 2024
Ferulic
acid
(FA)
is
a
phenolic
phytochemical
that
has
garnered
the
attention
of
research
community
due
to
its
abundant
availability
in
nature.
It
compound
been
explored
for
multifaceted
therapeutic
potential
and
benefits
modern
contemporary
healthcare.
Arabian Journal of Chemistry,
Год журнала:
2021,
Номер
14(12), С. 103449 - 103449
Опубликована: Сен. 22, 2021
•
2-methylindole
analogs
were
designed,
synthesized
and
characterized.
The
target
(
4a–4j
)
evaluated
for
their
inhibitory
potential
against
glutathione
S-transferase
(GST),
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE)
activities.
Molecular
docking
studies
conducted
to
correlate
the
in
vitro
results
identify
possible
mode
of
interactions
at
active
pocket
site
receptors.
pharmacokinetic
carried
out
using
SwissADMET
analyses.
In
this
study,
we
aimed
(i)
synthesize
new
containing
various
amino
structures,
pyrrolidine,
piperidine,
morpholine,
substituted
phenyl
groups
through
structural
molecular
modifications,
(ii)
evaluate
pharmaceutical
via
assessing
enzyme
activity
(BChE),
(iii)
predict
ADMET
properties
analogs,
(iv)
reveal
between
with
GST,
AChE,
BChE
enzymes
several
software.
inhibition
assays
showed
that
indole
exhibited
moderate
good
activities
enzymes.
Briefly,
4b
4i
4a
BChE,
1
GST
detected
be
higher
or
close
standard
inhibitor
compounds.
analog
was
have
best
both
AChE
lowest
IC
50
values
as
0.648
µM
0.745
BChE.
analyses
relationship
could
help
design
inhibitors
cholinergic
pathways
based
on
derivatives.
Journal of Functional Foods,
Год журнала:
2022,
Номер
95, С. 105180 - 105180
Опубликована: Июль 18, 2022
We
aimed
to
examine
the
hypothesis
that
dietary
ferulic
acid
and
vinpocetine
intake
improve
memory
deficits
caused
by
hippocampal
amyloid-β
accumulation
in
type
2
diabetic(T2DM)
rats
with
induced
Alzheimer's
disease(AD).
Their
mechanisms
were
also
tested.
Partial
pancreatectomized
animals
amyloid-β(25–35)
infusion
representing
Asian
T2DM
developed
AD
(AD
rats;
deficit).
After
eight-week
intervention,
impairment
was
impeded
AD-FRA
fed
acid(50
mg/kg
BW)
AD-VPC
vinpocetine(50
BW;
AD-VPC)
through
inhibition
of
deposition
neuroinflammation
compared
AD-CON.
The
showed
less
than
group.
groups
an
inhibited
attenuation
phosphorylated
Akt
→
glycogen-synthase
kinase(GSK)-3β
forkhead
box
protein
O1(FOXO1)
pathway,
similar
protection
as
CON.
No
adverse
effects
detected.
In
conclusion,
supplementation
suppressed
AD,
better
improvement
vinpocetine,
no
AD-induced
rats.
Molecules,
Год журнала:
2022,
Номер
27(3), С. 901 - 901
Опубликована: Янв. 28, 2022
Alzheimer’s
disease
(AD)
is
a
progressive,
neurodegenerative
disorder
that
currently
has
reached
epidemic
proportions
among
elderly
populations
around
the
world.
In
China,
available
traditional
Chinese
medicines
(TCMs)
organically
combine
functional
foods
with
medicinal
values
are
named
“Medicine
Food
Homology
(MFH)”.
this
review,
we
focused
on
MFH
varieties
for
their
features,
substance
bases,
clinical
uses,
and
mechanisms
of
action
(MOAs)
AD
prevention
treatment.
We
consider
antiAD
active
constituents
from
species,
effects
in
vitro/in
vivo
models,
drug
targets
signal
pathways
by
summing
up
literature
via
systematic
electronic
search
(SciFinder,
PubMed,
Web
Science).
paper,
several
plant
sources
discussed
detail
models
methods,
to
MOAs.
found
most
exert
neuroprotective
ameliorate
cognitive
impairments
inhibiting
neuropathological
signs
(Aβ-induced
toxicity,
amyloid
precursor
protein,
phosphorylated
Tau
immunoreactivity),
including
anti-inflammation,
antioxidative
stress,
antiautophagy,
antiapoptosis,
etc.
Indeed,
some
substances
related
phytochemicals
have
broad
spectrum
activities,
so
they
superior
simple
single-target
drugs
treating
chronic
diseases.
This
review
can
provide
significant
guidance
people’s
healthy
lifestyles
development
