Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action DOI Creative Commons
Pengfei Guo, Baoyue Zhang, Jun Zhao

и другие.

Molecules, Год журнала: 2022, Номер 27(3), С. 901 - 901

Опубликована: Янв. 28, 2022

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that currently has reached epidemic proportions among elderly populations around the world. In China, available traditional Chinese medicines (TCMs) organically combine functional foods with medicinal values are named “Medicine Food Homology (MFH)”. this review, we focused on MFH varieties for their features, substance bases, clinical uses, and mechanisms of action (MOAs) AD prevention treatment. We consider antiAD active constituents from species, effects in vitro/in vivo models, drug targets signal pathways by summing up literature via systematic electronic search (SciFinder, PubMed, Web Science). paper, several plant sources discussed detail models methods, to MOAs. found most exert neuroprotective ameliorate cognitive impairments inhibiting neuropathological signs (Aβ-induced toxicity, amyloid precursor protein, phosphorylated Tau immunoreactivity), including anti-inflammation, antioxidative stress, antiautophagy, antiapoptosis, etc. Indeed, some substances related phytochemicals have broad spectrum activities, so they superior simple single-target drugs treating chronic diseases. This review can provide significant guidance people’s healthy lifestyles development

Язык: Английский

Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease DOI
Yash Pal Singh, Harish Kumar

Chemical Biology & Drug Design, Год журнала: 2024, Номер 104(4)

Опубликована: Окт. 1, 2024

ABSTRACT Alzheimer's disease (AD) is a chronic progressive, age‐related neurodegenerative brain disorder characterized by the irreversible decline of memory and other cognitive functions. It one major health threat 21st century, which affects around 60% population over age 60 years. The problem this even more because existing pharmacotherapies only provide symptomatic relief without addressing basic factors disease. extracellular deposition amyloid β (Aβ) to form senile plaques, intracellular hyperphosphorylation tau neurofibrillary tangles (NFTs). Due complex pathophysiology disease, various hypotheses have been proposed, including cholinergic, Aβ, tau, oxidative stress, metal–ion hypothesis. Among these, cholinergic Aβ are primary targets for AD. Therefore, continuous advances made in developing potential cholinesterase inhibitors N ‐methyl‐D‐aspartate (NMDA) receptor antagonists delay progression restore neurotransmission. In review article, we tried comprehensively summarize recent advancement NMDA antagonist (memantine) their hybrid analogs as disease‐modifying agents treatment Furthermore, also depicted design, rationale, SAR analysis memantine‐based hybrids used last decade

Язык: Английский

Процитировано

6

2-methylindole analogs as cholinesterases and glutathione S-transferase inhibitors: Synthesis, biological evaluation, molecular docking, and pharmacokinetic studies DOI Creative Commons
Adnan Çetin, Ercan Bursal, Fikret Türkan

и другие.

Arabian Journal of Chemistry, Год журнала: 2021, Номер 14(12), С. 103449 - 103449

Опубликована: Сен. 22, 2021

• 2-methylindole analogs were designed, synthesized and characterized. The target ( 4a–4j ) evaluated for their inhibitory potential against glutathione S-transferase (GST), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities. Molecular docking studies conducted to correlate the in vitro results identify possible mode of interactions at active pocket site receptors. pharmacokinetic carried out using SwissADMET analyses. In this study, we aimed (i) synthesize new containing various amino structures, pyrrolidine, piperidine, morpholine, substituted phenyl groups through structural molecular modifications, (ii) evaluate pharmaceutical via assessing enzyme activity (BChE), (iii) predict ADMET properties analogs, (iv) reveal between with GST, AChE, BChE enzymes several software. inhibition assays showed that indole exhibited moderate good activities enzymes. Briefly, 4b 4i 4a BChE, 1 GST detected be higher or close standard inhibitor compounds. analog was have best both AChE lowest IC 50 values as 0.648 µM 0.745 BChE. analyses relationship could help design inhibitors cholinergic pathways based on derivatives.

Язык: Английский

Процитировано

31

The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease DOI Creative Commons
Ancuța-Veronica Lupăescu,

Monica Iavorschi,

Mihai Covașă

и другие.

Pharmaceutics, Год журнала: 2022, Номер 14(2), С. 235 - 235

Опубликована: Янв. 20, 2022

It has become increasingly apparent that defective insulin signaling may increase the risk for developing Alzheimer’s disease (AD), influence neurodegeneration through promotion of amyloid formation or by increasing inflammatory responses to intraneuronal β-amyloid. Recent work demonstrated hyperglycemia is linked cognitive decline, with elevated levels glucose causing oxidative stress in vulnerable tissues such as brain. The ability β-amyloid peptide form β-sheet-rich aggregates and induce apoptosis made fibrils a leading target development novel pharmacotherapies used managing treatment neuropathological conditions AD-related decline. Additionally, deposits β-sheets folded amylin, homeostasis regulator, are also present diabetic patients. Thus, therapeutic compounds capable reducing intracellular protein aggregation models neurodegenerative disorders prove useful ameliorating type 2 diabetes mellitus symptoms. Furthermore, both conditions, AD, characterized chronic accompanied presence dysregulated biomarkers. This review presents current evidence describing role various small bioactive molecules known ameliorate amyloidosis subsequent effects prevention AD. highlights potential efficacy peptide–drug conjugates targeting targets.

Язык: Английский

Процитировано

23

Ferulic acid and vinpocetine intake improves memory function by enhancing insulin sensitivity and reducing neuroinflammation and oxidative stress in type 2 diabetic animals with induced Alzheimer's disease DOI Creative Commons
Sunmin Park,

Na Rang Moon,

Suna Kang

и другие.

Journal of Functional Foods, Год журнала: 2022, Номер 95, С. 105180 - 105180

Опубликована: Июль 18, 2022

We aimed to examine the hypothesis that dietary ferulic acid and vinpocetine intake improve memory deficits caused by hippocampal amyloid-β accumulation in type 2 diabetic(T2DM) rats with induced Alzheimer's disease(AD). Their mechanisms were also tested. Partial pancreatectomized animals amyloid-β(25–35) infusion representing Asian T2DM developed AD (AD rats; deficit). After eight-week intervention, impairment was impeded AD-FRA fed acid(50 mg/kg BW) AD-VPC vinpocetine(50 BW; AD-VPC) through inhibition of deposition neuroinflammation compared AD-CON. The showed less than group. groups an inhibited attenuation phosphorylated Akt → glycogen-synthase kinase(GSK)-3β forkhead box protein O1(FOXO1) pathway, similar protection as CON. No adverse effects detected. In conclusion, supplementation suppressed AD, better improvement vinpocetine, no AD-induced rats.

Язык: Английский

Процитировано

22

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action DOI Creative Commons
Pengfei Guo, Baoyue Zhang, Jun Zhao

и другие.

Molecules, Год журнала: 2022, Номер 27(3), С. 901 - 901

Опубликована: Янв. 28, 2022

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that currently has reached epidemic proportions among elderly populations around the world. In China, available traditional Chinese medicines (TCMs) organically combine functional foods with medicinal values are named “Medicine Food Homology (MFH)”. this review, we focused on MFH varieties for their features, substance bases, clinical uses, and mechanisms of action (MOAs) AD prevention treatment. We consider antiAD active constituents from species, effects in vitro/in vivo models, drug targets signal pathways by summing up literature via systematic electronic search (SciFinder, PubMed, Web Science). paper, several plant sources discussed detail models methods, to MOAs. found most exert neuroprotective ameliorate cognitive impairments inhibiting neuropathological signs (Aβ-induced toxicity, amyloid precursor protein, phosphorylated Tau immunoreactivity), including anti-inflammation, antioxidative stress, antiautophagy, antiapoptosis, etc. Indeed, some substances related phytochemicals have broad spectrum activities, so they superior simple single-target drugs treating chronic diseases. This review can provide significant guidance people’s healthy lifestyles development

Язык: Английский

Процитировано

21