The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways DOI
Xiao Zhang,

Yidong Xiao,

Qilin Huang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125747 - 125747

Опубликована: Июль 8, 2023

Язык: Английский

Targeting the PDGF/PDGFR signaling pathway for cancer therapy: A review DOI
Zou Xiang,

Xi-Yu Tang,

Zhongyuan Qu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 202, С. 539 - 557

Опубликована: Янв. 21, 2022

Язык: Английский

Процитировано

150

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis DOI
Kaijun Wang, Jie Yin, Jiayi Chen

и другие.

Phytomedicine, Год журнала: 2024, Номер 128, С. 155258 - 155258

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

56

Targeted therapy for osteosarcoma: a review DOI
Shizhe Li, He Zhang, Jinxin Liu

и другие.

Journal of Cancer Research and Clinical Oncology, Год журнала: 2023, Номер 149(9), С. 6785 - 6797

Опубликована: Фев. 18, 2023

Язык: Английский

Процитировано

48

The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer DOI Creative Commons
Naoshad Muhammad,

Darksha Usmani,

Mohammad Tarique

и другие.

Cells, Год журнала: 2022, Номер 11(14), С. 2209 - 2209

Опубликована: Июль 15, 2022

Natural products play a critical role in the discovery and development of numerous drugs for treatment various types cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with initiation, development, progression cancer through altering mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, metastasis. Treating multifactorial diseases, agents targeting single target, might lead to limited success and, many cases, unsatisfactory outcomes. Various epidemiological studies shown that steady consumption fruits vegetables is intensely associated reduced risk Since ancient period, plants, herbs, other natural been used healing agents. Likewise, most medicinal ingredients accessible today are originated from resources. Regardless achievements, developing bioactive compounds has remained challenging, part because problem large-scale sequestration mechanistic understanding. With significant progress landscape therapy rising use cutting-edge technologies, we may come crossroads review approaches identify potential investigate their therapeutic efficacy. In present review, summarize recent developments products-based research its application generating novel systemic strategies focus on underlying molecular solid

Язык: Английский

Процитировано

64

Remodeling tumor microenvironment with natural products to overcome drug resistance DOI Creative Commons
Wanlu Zhang, Shubo Li, Chunting Li

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.

Язык: Английский

Процитировано

41

Combining Crocin and Sorafenib Improves Their Tumor-Inhibiting Effects in a Rat Model of Diethylnitrosamine-Induced Cirrhotic-Hepatocellular Carcinoma DOI Open Access
Basma Awad, Alaaeldin Ahmed Hamza,

Amna Al-Maktoum

и другие.

Cancers, Год журнала: 2023, Номер 15(16), С. 4063 - 4063

Опубликована: Авг. 11, 2023

Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies, with continuously increasing cases and fatalities. Diagnosis often occurs in advanced stages, confining patients to systemic therapies such as sorafenib. Sorafenib (SB), a multi-kinase inhibitor, has not yet demonstrated sufficient efficacy against HCC. There strong argument favor studying its use combination other medications optimize therapeutic results. According our earlier work, crocin (CR), key bioactive component saffron, hinders HCC development liver cancer stemness. In this study, we investigated CR or SB cirrhotic rat model evaluated how effectively inhibited tumor growth model. Diethylnitrosamine (DEN) was administered intraperitoneally rats once week for 15 weeks, leading cirrhosis, then 19 weeks later, multifocal After 16 induction, (200 mg/kg daily) (10 were given orally three either separately combination. Consistently, treatment considerably decreased incidence dyschromatic nodules, nodule multiplicity, dysplastic nodules when compared group single therapies. Combined therapy also caused highest degree apoptosis, along proliferating β-catenin levels tissues. Additionally, received combined CR, it showed anti-inflammatory characteristics where nuclear factor kappa B (NF-κB) cyclooxygenase-2 (Cox-2) additively lowered. As result, potentiates suppressive effects on provides opportunity strengthen

Язык: Английский

Процитировано

41

Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer DOI Creative Commons
Alaa Elmetwalli,

Shimaa Mustafa Hashish,

Mervat G. Hassan

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 396(11), С. 3087 - 3099

Опубликована: Май 9, 2023

Abstract Cancer cells can become resistant to existing treatments over time, so it is important develop new that target different pathways stay ahead of this resistance. Many cancer have severe side effects be debilitating and even life-threatening. Developing drugs effectively treat while minimizing the risks these essential for improving quality life patients. The study was designed explore whether combination dicinnamoyl-L-tartaric (CLT) sorafenib ((SOR), an anti-cancer drug)) could used hepatocellular carcinoma (HCC) in animal model assess would lead changes certain biomarkers associated with tumour. In study, 120 male mice were divided into 8 groups 15 each. A number biochemical parameters measured, including liver functions, oxidative stress (malondialdehyde, (MDA); nitric oxide (NO)), antioxidative activity (superoxide dismutase (SOD), glutathione peroxidase (GPx)). Furthermore, hepatic expressions Bax , Beclin1 TNF - α IL1β BCl-2 genes evaluated by qRT-PCR. SOR CLT found reduce levels enzymes, such as AST, ALT, ALP, GGT, pathological caused DAB PB. upregulation TNF-α Bcl-2 suggests able initiate inflammatory response combat tumor, downregulation indicates risk apoptosis liver. therapy led increased expression cytokines, resulting enhanced anti-tumor effect.

Язык: Английский

Процитировано

26

Combination strategies for first-line treatment of patients with unresectable hepatocellular carcinoma: prospect of natural products DOI
Lele Zhang, Jin‐Jian Lu

Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(1), С. 1 - 3

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

12

Hepatocellular carcinoma and lipid metabolism: Novel targets and therapeutic strategies DOI

Lu-Qi Cao,

Yuhao Xie, Joshua S. Fleishman

и другие.

Cancer Letters, Год журнала: 2024, Номер 597, С. 217061 - 217061

Опубликована: Июнь 13, 2024

Язык: Английский

Процитировано

12

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms DOI Open Access
Jinhong Guo, Wenjie Yan,

Hao Duan

и другие.

Nutrients, Год журнала: 2024, Номер 16(11), С. 1642 - 1642

Опубликована: Май 27, 2024

Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, minimal side effects. This paper begins by reviewing existing treatment methods drugs liver cancer. It then summarizes the therapeutic effects NPs sourced from various origins on Finally, we analyze potential mechanisms treating cancer, including inhibition angiogenesis, migration, invasion; regulation cell cycle; induction apoptosis, autophagy, pyroptosis, ferroptosis; influence tumor metabolism; immune regulation; intestinal function; key signaling pathways. systematic review aims provide comprehensive overview research treatment, offering foundation further application pharmaceuticals functional foods.

Язык: Английский

Процитировано

11