International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125747 - 125747
Опубликована: Июль 8, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125747 - 125747
Опубликована: Июль 8, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2022, Номер 202, С. 539 - 557
Опубликована: Янв. 21, 2022
Язык: Английский
Процитировано
150Phytomedicine, Год журнала: 2024, Номер 128, С. 155258 - 155258
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
56Journal of Cancer Research and Clinical Oncology, Год журнала: 2023, Номер 149(9), С. 6785 - 6797
Опубликована: Фев. 18, 2023
Язык: Английский
Процитировано
48Cells, Год журнала: 2022, Номер 11(14), С. 2209 - 2209
Опубликована: Июль 15, 2022
Natural products play a critical role in the discovery and development of numerous drugs for treatment various types cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with initiation, development, progression cancer through altering mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, metastasis. Treating multifactorial diseases, agents targeting single target, might lead to limited success and, many cases, unsatisfactory outcomes. Various epidemiological studies shown that steady consumption fruits vegetables is intensely associated reduced risk Since ancient period, plants, herbs, other natural been used healing agents. Likewise, most medicinal ingredients accessible today are originated from resources. Regardless achievements, developing bioactive compounds has remained challenging, part because problem large-scale sequestration mechanistic understanding. With significant progress landscape therapy rising use cutting-edge technologies, we may come crossroads review approaches identify potential investigate their therapeutic efficacy. In present review, summarize recent developments products-based research its application generating novel systemic strategies focus on underlying molecular solid
Язык: Английский
Процитировано
64Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Ноя. 10, 2022
With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.
Язык: Английский
Процитировано
41Cancers, Год журнала: 2023, Номер 15(16), С. 4063 - 4063
Опубликована: Авг. 11, 2023
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies, with continuously increasing cases and fatalities. Diagnosis often occurs in advanced stages, confining patients to systemic therapies such as sorafenib. Sorafenib (SB), a multi-kinase inhibitor, has not yet demonstrated sufficient efficacy against HCC. There strong argument favor studying its use combination other medications optimize therapeutic results. According our earlier work, crocin (CR), key bioactive component saffron, hinders HCC development liver cancer stemness. In this study, we investigated CR or SB cirrhotic rat model evaluated how effectively inhibited tumor growth model. Diethylnitrosamine (DEN) was administered intraperitoneally rats once week for 15 weeks, leading cirrhosis, then 19 weeks later, multifocal After 16 induction, (200 mg/kg daily) (10 were given orally three either separately combination. Consistently, treatment considerably decreased incidence dyschromatic nodules, nodule multiplicity, dysplastic nodules when compared group single therapies. Combined therapy also caused highest degree apoptosis, along proliferating β-catenin levels tissues. Additionally, received combined CR, it showed anti-inflammatory characteristics where nuclear factor kappa B (NF-κB) cyclooxygenase-2 (Cox-2) additively lowered. As result, potentiates suppressive effects on provides opportunity strengthen
Язык: Английский
Процитировано
41Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 396(11), С. 3087 - 3099
Опубликована: Май 9, 2023
Abstract Cancer cells can become resistant to existing treatments over time, so it is important develop new that target different pathways stay ahead of this resistance. Many cancer have severe side effects be debilitating and even life-threatening. Developing drugs effectively treat while minimizing the risks these essential for improving quality life patients. The study was designed explore whether combination dicinnamoyl-L-tartaric (CLT) sorafenib ((SOR), an anti-cancer drug)) could used hepatocellular carcinoma (HCC) in animal model assess would lead changes certain biomarkers associated with tumour. In study, 120 male mice were divided into 8 groups 15 each. A number biochemical parameters measured, including liver functions, oxidative stress (malondialdehyde, (MDA); nitric oxide (NO)), antioxidative activity (superoxide dismutase (SOD), glutathione peroxidase (GPx)). Furthermore, hepatic expressions Bax , Beclin1 TNF - α IL1β BCl-2 genes evaluated by qRT-PCR. SOR CLT found reduce levels enzymes, such as AST, ALT, ALP, GGT, pathological caused DAB PB. upregulation TNF-α Bcl-2 suggests able initiate inflammatory response combat tumor, downregulation indicates risk apoptosis liver. therapy led increased expression cytokines, resulting enhanced anti-tumor effect.
Язык: Английский
Процитировано
26Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(1), С. 1 - 3
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
12Cancer Letters, Год журнала: 2024, Номер 597, С. 217061 - 217061
Опубликована: Июнь 13, 2024
Язык: Английский
Процитировано
12Nutrients, Год журнала: 2024, Номер 16(11), С. 1642 - 1642
Опубликована: Май 27, 2024
Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, minimal side effects. This paper begins by reviewing existing treatment methods drugs liver cancer. It then summarizes the therapeutic effects NPs sourced from various origins on Finally, we analyze potential mechanisms treating cancer, including inhibition angiogenesis, migration, invasion; regulation cell cycle; induction apoptosis, autophagy, pyroptosis, ferroptosis; influence tumor metabolism; immune regulation; intestinal function; key signaling pathways. systematic review aims provide comprehensive overview research treatment, offering foundation further application pharmaceuticals functional foods.
Язык: Английский
Процитировано
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