Copper catalysed regioselective synthesis of pyrimidine substituted Indolizino[8,7-b]indole derivatives via cascade A3 annulation DOI
Sunit Kumar, Rakesh Kumar, Chandi C. Malakar

и другие.

Tetrahedron, Год журнала: 2023, Номер 142, С. 133547 - 133547

Опубликована: Июль 8, 2023

Язык: Английский

Discovery of Novel Pimprinine and Streptochlorin Derivatives as Potential Antifungal Agents DOI Creative Commons
Jing‐Rui Liu,

Jia‐Mu Liu,

Ya Gao

и другие.

Marine Drugs, Год журнала: 2022, Номер 20(12), С. 740 - 740

Опубликована: Ноя. 25, 2022

Pimprinine and streptochlorin are indole alkaloids derived from marine or soil microorganisms. In our previous study, they were promising lead compounds due to their potent bioactivity in preventing many phytopathogens, but further structural modifications required improve antifungal activity. this pimprinine used as parent structures with the combination strategy of features. Three series target designed synthesized. Subsequent evaluation for activity against six common phytopathogenic fungi showed that some thee possessed excellent effects, is highlighted by 4a 5a, displaying 99.9% growth inhibition Gibberella zeae Alternaria Leaf Spot under 50 μg/mL, respectively. EC50 values indicated 4a, 8c, 8d even more active than Azoxystrobin Boscalid. SAR analysis revealed relationship between 5-(3′-indolyl)oxazole scaffold activity, which provides useful insight into development new molecules. Molecular docking models indicate compound binds leucyl-tRNA synthetase a similar mode AN2690, offering perspective on action study its These results suggest 5a could be regarded novel agents phytopathogens valuable potency.

Язык: Английский

Процитировано

6
Novel spiro[pyrrolidine-2,3′-quinoline]-2′-one derivatives containing piperazine fragment as potential chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation DOI

Lige Liu,

Hu Wu,

Yan Long

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 260, С. 115777 - 115777

Опубликована: Авг. 31, 2023

Язык: Английский

Процитировано

2
Discovery and identification of natural alkaloids with potential to impact insulin resistance syndrome in Cyclocarya paliurus. (Batal) leaves by UPLC-QTOF-MS combined with HepG2 cells DOI
Liang Lü, Zhongwei Liu,

Weixiang Xu

и другие.

Food Research International, Год журнала: 2024, Номер 190, С. 114545 - 114545

Опубликована: Май 31, 2024

Язык: Английский

Процитировано

0
Asymmetric Total Synthesis of Alstrostine G Utilizing a Catalytic Asymmetric Desymmetrization Strategy DOI

Nanping Zhang,

Cheng Wang, Hailong Xu

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(34)

Опубликована: Май 31, 2024

Abstract A highly effective enantioselective monobenzoylation of 1,3‐diols has been developed for the synthesis 1,1‐disubstituted tetrahydro‐β‐carbolines. The chemistry successfully applied to asymmetric total (+)‐alstrostine G, which also features a cascade Heck/hemiamination reaction enabling facile construction pivotal pentacyclic core.

Язык: Английский

Процитировано

0
Copper catalysed regioselective synthesis of pyrimidine substituted Indolizino[8,7-b]indole derivatives via cascade A3 annulation DOI
Sunit Kumar, Rakesh Kumar, Chandi C. Malakar

и другие.

Tetrahedron, Год журнала: 2023, Номер 142, С. 133547 - 133547

Опубликована: Июль 8, 2023

Язык: Английский

Процитировано

1