Brain Sciences,
Год журнала:
2022,
Номер
12(5), С. 672 - 672
Опубликована: Май 21, 2022
Parkinson’s
disease
(PD)
is
a
chronic
progressive
neurodegenerative
that
increasingly
becoming
global
threat
to
the
health
and
life
of
elderly
worldwide.
Although
there
are
some
drugs
clinically
available
for
treating
PD,
these
treatments
can
only
alleviate
symptoms
PD
patients
but
cannot
completely
cure
disease.
Therefore,
exploring
other
potential
mechanisms
develop
more
effective
modify
course
still
highly
desirable.
Over
last
two
decades,
histone
deacetylases,
as
an
important
group
epigenetic
targets,
have
attracted
much
attention
in
drug
discovery.
This
review
focused
on
current
knowledge
about
deacetylases
involved
pathophysiology
their
inhibitors
used
studies.
Further
perspectives
related
small
molecules
inhibit
or
degrade
treat
were
also
discussed.
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(5), С. 1748 - 1777
Опубликована: Апрель 29, 2023
Abstract
Parkinson's
disease
(PD)
is
a
multifactorial
due
to
complex
interplay
between
genetic
and
epigenetic
factors.
Recent
efforts
shed
new
light
on
the
mechanisms
involved
in
regulating
pathways
related
development
of
PD,
including
DNA
methylation,
posttranslational
modifications
histones,
presence
microRNA
(miRNA
or
miR).
Epigenetic
regulators
are
potential
therapeutic
targets
for
neurodegenerative
disorders.
In
review,
we
aim
summarize
regulation
describe
how
methyltransferases,
histone
deacetylases,
acetyltransferases
that
mediate
key
processes
PD
attractive
targets.
We
discuss
use
inhibitors
and/or
activators
these
models
patients,
small
molecule
modulators
elicit
neuroprotective
effects.
Further
more,
given
importance
miRNAs
their
contributions
underlying
will
be
discussed
as
well,
together
with
miRNA‐based
therapies.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
275, С. 133680 - 133680
Опубликована: Июль 4, 2024
Proteolysis
targeting
chimeras
(PROTACs)
can
use
the
intrinsic
protein
degradation
system
in
cells
to
degrade
pathogenic
target
proteins,
and
are
currently
a
revolutionary
frontier
of
development
strategy
for
tumor
treatment
with
small
molecules.
However,
poor
water
solubility,
low
cellular
permeability,
off-target
side
effects
most
PROTACs
have
prevented
them
from
passing
preclinical
research
stage
drug
development.
This
requires
appropriate
delivery
systems
overcome
these
challenging
hurdles
ensure
precise
towards
site.
Therefore,
combination
multifunctional
will
open
up
new
directions
targeted
proteins.
In
this
review,
we
systematically
reviewed
design
principles
recent
advances
various
systems.
Moreover,
constructive
strategies
developing
were
proposed
comprehensively.
review
aims
deepen
understanding
drugs
promote
further
system.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(4), С. 100941 - 100941
Опубликована: Июль 10, 2024
Leucine-rich
α-2
glycoprotein
1
(LRG1),
a
secreted
glycoprotein,
has
been
identified
as
significantly
upregulated
in
renal
fibrosis,
potentially
exacerbating
the
condition
by
enhancing
TGF-β-Smad3-dependent
signaling
pathways.
Herein,
utilizing
our
developed
LRG1-targeting
peptide
for
LRG1
recruitment
and
lenalidomide
E3
ubiquitin
ligase
engagement,
we
an
advanced
proteolysis
targeting
chimera,
Brain Sciences,
Год журнала:
2022,
Номер
12(5), С. 672 - 672
Опубликована: Май 21, 2022
Parkinson’s
disease
(PD)
is
a
chronic
progressive
neurodegenerative
that
increasingly
becoming
global
threat
to
the
health
and
life
of
elderly
worldwide.
Although
there
are
some
drugs
clinically
available
for
treating
PD,
these
treatments
can
only
alleviate
symptoms
PD
patients
but
cannot
completely
cure
disease.
Therefore,
exploring
other
potential
mechanisms
develop
more
effective
modify
course
still
highly
desirable.
Over
last
two
decades,
histone
deacetylases,
as
an
important
group
epigenetic
targets,
have
attracted
much
attention
in
drug
discovery.
This
review
focused
on
current
knowledge
about
deacetylases
involved
pathophysiology
their
inhibitors
used
studies.
Further
perspectives
related
small
molecules
inhibit
or
degrade
treat
were
also
discussed.
