Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

Molecules, Год журнала: 2023, Номер 28(7), С. 3264 - 3264

Опубликована: Апрель 6, 2023

species have been recognized as potential antimicrobial (AM) agents and used in traditional Chinese medicine (TCM) for a long time. The aim of this study is to examine the AM autochthonous

Язык: Английский

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Tricyclic microwave-assisted synthesis of gold nanoparticles for biomedical applications: combatting multidrug-resistant bacteria and fungus

Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2024, Номер 13(1)

Опубликована: Июнь 7, 2024

Abstract Background Rising global mortality due to antibiotic-resistant pathogens necessitates novel antibacterial and antifungal agents. This study focuses on synthesizing gold nanoparticles (GNPs) via tricyclic microwave irradiation (TMI) combat Multi-Drug-Resistant Bacteria Fungus. The demand for sustainable synthesis methods has led the exploration of TMI GNP production. Results Characterization demonstrates consistent, uniform, dispersed GNPs with trigonal hexagonal shapes. sized 20–55 nm exhibit superior activity, particularly against drug-resistant Gram-positive bacteria. Notably, display consistent efficacy fungus demonstrate potential broad-spectrum antimicrobial applications. Conclusion TMI-synthesized GNPs, characterized by their favorable physical properties size-dependent efficacy, show promise as effective agents pathogens. Their ability bacteria, Gram-negative positions them valuable tools in biomedical sciences. By addressing urgent need agents, offer a solution escalating health challenge antibiotic resistance.

Язык: Английский

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Rhino-orbito-cerebral mucormycosis after allogeneic hematopoietic stem cell transplantation for very severe aplastic anemia in a child: a case report

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Апрель 14, 2025

Rhino-orbito-cerebral mucormycosis (ROCM) is a rare and life-threatening fungal infection that predominantly affects immunocompromised individuals, such as those undergoing hematopoietic stem cell transplantation (HSCT). This report describes the case of 10-year-old girl with very severe aplastic anemia (VSAA) who underwent an haploidentical HSCT from her father. She initially achieved successful engraftment donor chimerism rate 98.25% on day 60. However, 65 post-transplant, she developed right-eye pain, progressive swelling, visual impairment. Comprehensive evaluations, including contrast-enhanced magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) analysis, revealed extensive orbital cerebral involvement consistent ROCM. Intensive antifungal therapy liposomal amphotericin B posaconazole, along endoscopic surgical debridement infected sinuses regions, was initiated. Post-treatment MRI scans demonstrated significant reduction in edema other abnormalities, while repeated CSF analyses confirmed absence elements. underscores critical need for early diagnosis aggressive management ROCM patients, particularly following HSCT.

Язык: Английский

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Management of a pediatric patient with rapidly progressive glomerulonephritis and cutaneous mucormycosis: a case report

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Май 8, 2025

Mucormycosis is a highly invasive and rare opportunistic infection caused by mucor fungi, characterized challenging diagnosis rapid disease progression. It predominantly affects patients with compromised immune systems due to various reasons, such as kidney failure, long-term use of antibiotics or corticosteroids. We recently successfully treated pediatric patient rapidly progressive glomerulonephritis accompanied severe cutaneous mucormycosis. To our knowledge, this the first reported case nephritis dermatophytosis in patient. In case, we share management experience, including special nursing experience. Cutaneous mucormycosis progresses quickly difficult diagnose treat, especially children function, warranting high vigilance from clinicians staff. Early targeted treatment are crucial for improving prognosis patients. Therefore, once there suspicion infection, recommend early application testing methods fungal culture, skin biopsy genetic order promptly confirm diagnosis.

Язык: Английский

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Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(18), С. 13007 - 13027

Опубликована: Сен. 14, 2023

Dual-target (CYP51/PD-L1) plays an important role in the process of fungal proliferation and immune suppression. A series novel quinazoline compounds with dual-target inhibition function was constructed using skeleton growth method, their structures were synthesized, characterized, evaluated. Among them, perfected (L11, L20, L21) selected for further study, which exhibited remarkable biological activity against different strains (MIC50, 0.25-2.0 μg/mL) vitro. On one hand, these inhibited CYP51 activity, induced ROS aggregation, mitochondrial damage; this ultimately caused lysis death. other they also effectively activated body's ability by blocking interaction between PD-L1 PD-1, slowed down inflammatory reaction, accelerated recovery infections.

Язык: Английский

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Construction and Evaluation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(19), С. 13838 - 13857

Опубликована: Сен. 26, 2023

In this study, PD-L1 and CYP51 were selected as key dual-target enzymes, which play an important role in the process of fungal proliferation immune suppression. A series novel bifonazole compounds designed through method fragment combination. Their chemical structure was synthesized, characterized, evaluated. Among them, (10c-1, 14a-2, 17c-2) exhibited excellent antifungal antidrug-resistant activity vitro. particular, preferred compound 14a-2 with high-efficiency inhibitor ability could block activate organism's efficacy. Moreover, corresponding covalent organic framework carrier also successfully constructed to improve its bioavailability. This significantly accelerated body's recovery from infection vivo. summary, study expanded scientific frontier drugs provided a feasible candidate pathway for clinical treatment infections.

Язык: Английский

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Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(10), С. 8420 - 8444

Опубликована: Май 8, 2024

Faced with increasingly serious fungal infections and drug resistance issues, three different series of novel dual-target (programmed death ligand 1/14 α-demethylase) compounds were constructed through the fragment combination pathway in study. Their chemical structures synthesized, characterized, evaluated. Among them, preferred 10c-1, 17b-1, 18b-2 could efficiently exert their antifungal antidrug-resistant ability blocking ergosterol biosynthesis, inducing upregulation reactive oxygen species level, triggering apoptosis. Especially, compound exhibited synergistic function inhibition immune activation. Moreover, covalent organic framework carrier was also generated based on acidic microenvironment infection to improve bioavailability targeting compounds; this finally accelerated body's recovery rate.

Язык: Английский

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Visible light-promoted, catalyst-free synthesis of isoniazid azomethines: In vitro antioxidant activity, Molecular Docking, ADME and toxicity prediction

Journal of Molecular Structure, Год журнала: 2024, Номер 1322, С. 140686 - 140686

Опубликована: Ноя. 9, 2024

Язык: Английский

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Review on Mucormycosis: Pathogenesis, Epidemiology, Microbiology and Diagnosis

Infectious Disorders - Drug Targets, Год журнала: 2023, Номер 24(1)

Опубликована: Авг. 23, 2023

Mucormycosis is a serious and invasive fungal infection caused by Mucorales fungi. This review article provides concise overview of the pathogenesis, epidemiology, microbiology, diagnosis mucormycosis. The introduction section highlights key microbiological properties pathogen delves into underlying mechanisms mucormycosis including invasion proliferation fungus within host. description disease focuses on epidemiology mucormycosis, its incidence, risk factors, geographical distribution. It also explores specific context about COVID-19 diabetes mellitus, highlighting increased susceptibility observed in individuals with these conditions. A case study illustrates clinical manifestations challenges associated emphasizing importance early detection. Additionally, discusses significance assessment, radiological imaging, tests for accurate timely detection infection. Regarding treatment, covers various therapeutic approaches, antifungal therapy, surgical interventions, management predisposing limitations treatment options are addressed. aims to provide comprehensive understanding equipping healthcare professionals valuable insights diagnostic strategies. By enhancing knowledge awareness this infection, can improve patient outcomes through appropriate management.

Язык: Английский

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Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis

ACS Infectious Diseases, Год журнала: 2024, Номер 10(5), С. 1431 - 1457

Опубликована: Апрель 29, 2024

Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, crowded settings. Major contributing factors include diabetes weakened immune systems. main manifesting forms of CAM─cutaneous, pulmonary, deadliest, rhinocerebral─and disseminated infections elevated mortality rates 85%. Recent focus lies on small-molecule inhibitors due their advantages over standard treatments like surgery liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, simpler dosing owing small size, rendering ability traverse blood–brain barrier via passive diffusion facilitated by phospholipid membrane. Adaptation versatility mucormycosis are multitude virulence factors, enabling pathogen dynamically respond various environmental stressors. A comprehensive understanding these mechanisms imperative for devising effective therapeutic interventions against this highly opportunistic that thrives immunocompromised individuals through its angio-invasive nature. Hence, Review delineates principal it employs persist challenging host environments, current progress developing them.

Язык: Английский

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