Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1059 - 1059
Опубликована: Фев. 28, 2024
The
Euodia
genus
comprises
numerous
untapped
medicinal
plants
that
warrant
thorough
evaluation
for
their
potential
as
valuable
natural
sources
of
herbal
medicine
or
food
flavorings.
In
this
study,
untargeted
metabolomics
and
in
vitro
functional
methods
were
employed
to
analyze
fruit
extracts
from
11
significant
species
the
genus.
An
investigation
distribution
metabolites
(quinolone
indole
quinazoline
alkaloids)
these
indicated
E.
rutaecarpa
(Euodia
rutaecarpa)
was
most
widely
distributed
species,
followed
by
compacta
compacta),
glabrifolia
glabrifolia),
austrosinensis
austrosinensis),
fargesii
fargesii).
There
have
been
reports
on
close
correlation
between
alkaloids
anti-tumor
activity,
especially
fruits
which
exhibit
effectiveness
against
various
types
cancer,
such
SGC-7901,
Hela,
A549,
other
cancer
cell
lines.
Additionally,
plant
contains
alkaloids,
possess
remarkable
antibacterial
properties.
Our
results
offer
novel
insights
into
utilization
resources
pharmaceutical
industry.
Язык: Английский
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Bioorganic Chemistry,
Год журнала:
2023,
Номер
143, С. 107076 - 107076
Опубликована: Дек. 30, 2023
Design
of
tubulin
inhibitors
as
anticancer
drugs
dynamically
developed
over
the
past
20
years.
The
modern
arsenal
potential
tubulin-targeting
agents
is
represented
by
small
molecules,
monoclonal
antibodies,
and
antibody-drug
conjugates.
Moreover,
targeting
has
been
a
successful
strategy
in
development
antiparasitic
drugs.
In
present
review,
an
overall
picture
research
using
molecules
between
2018
2023
provided.
data
about
some
most
often
used
prospective
chemotypes
(privileged
heterocycles,
moieties
natural
molecules)
synthetic
methodologies
(analogue-based,
fragment-based
drug
design,
molecular
hybridization)
applied
for
design
novel
with
impact
on
system
are
summarized.
prospects
multi-target
were
also
highlighted.
Reported
review
contribute
to
"structure-activity"
profile
will
be
useful
application
medicinal
chemists
further
exploration,
improvement,
optimization
this
class
molecules.
Язык: Английский
Evodiamine: A Extremely Potential Drug Development Candidate of Alkaloids from Evodia rutaecarpa
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 9843 - 9870
Опубликована: Сен. 1, 2024
Evodiamine
(EVO)
is
a
tryptamine
indole
alkaloid
and
the
main
active
ingredient
in
Язык: Английский
Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors Useful Against Colon Cancer
Anti-Cancer Agents in Medicinal Chemistry,
Год журнала:
2023,
Номер
24(4), С. 236 - 262
Опубликована: Дек. 1, 2023
Colorectal
cancer
(CRC)
is
the
third
most
common
globally,
with
high
mortality.
Metastatic
CRC
incurable
in
cases,
and
multiple
drug
therapy
can
increase
patients'
life
expectancy
by
2
to
3
years.
Efforts
are
being
made
understand
relationship
between
topoisomerase
enzymes
colorectal
cancer.
Some
studies
have
shown
that
higher
expression
of
these
correlated
a
poor
prognosis
for
this
type
One
primary
drugs
used
treatment
Irinotecan,
which
be
monotherapy
or,
more
commonly,
therapeutic
schemes
such
as
FOLFIRI
(Fluorouracil,
Leucovorin,
Irinotecan)
CAPIRI
(Capecitabine
Irinotecan).
Like
Camptothecin,
Irinotecan
other
compounds
mechanism
action
based
on
formation
ternary
complex
I
DNA
providing
damage
it,
therefore
leading
cell
death.
Thus,
review
focused
principal
works
published
last
ten
years
demonstrate
correlation
inhibition
different
isoforms
Язык: Английский
Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway
Bioorganic Chemistry,
Год журнала:
2023,
Номер
143, С. 107069 - 107069
Опубликована: Дек. 29, 2023
Язык: Английский
Design, Synthesis and Biological Evaluation of Plant-Derived Miliusol derivatives achieve TNBC profound regression in vivo
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
279, С. 116882 - 116882
Опубликована: Сен. 18, 2024
Язык: Английский
Structure-activity relationship study of novel evodiamine amino acid conjugates with potent anti-colorectal cancer efficacy
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
283, С. 117132 - 117132
Опубликована: Дек. 3, 2024
Язык: Английский
Novel Sulfonyl-Substituted Tetrandrine Derivatives for Colon Cancer Treatment by Inducing Mitochondrial Apoptosis and Inhibiting PI3K/AKT/mTOR Pathway
Опубликована: Янв. 1, 2023
Tetrandrine
(TET)
possesses
multiple
pharmacological
activities
and
could
suppress
tumor
proliferation
via
PI3K
pathway
inhibition.
However,
inferior
antitumor
activity
potential
toxicity
limit
its
clinical
application.
In
the
present
study,
a
series
of
14-sulfonamide
sulfonate
TET
derivatives
were
designed,
synthesized,
evaluated
for
biological
activities.
Through
structural-activity
relationship
studies,
compound
3c
with
α,
β-unsaturated
carbonyl
group
exhibited
most
potent
against
all
tested
cell
lines
(including
Hela,
HCT116,
HepG2,
MCF-7,
SHSY5Y),
as
well
negligible
normal
LO2
HEK293.
Additionally,
effectively
inhibited
HCT116
CT26
in
vitro
increased
proportion
G2/M
phase,
activated
mitochondrial
apoptosis
pathway,
induced
colon
cancer
by
suppressing
PI3K/AKT/mTOR
pathway.
The
further
molecular
docking
results
confirmed
that
is
potentially
bound
to
residues
stronger
binding
affinity
than
TET.
Ultimately,
dramatically
suppressed
growth
xenograft
model,
without
noticeable
visceral
detected
high-dose
group.
summary,
might
new
insights
designing
inhibitors
be
candidate
treatment.
Язык: Английский