Synthesis of new fluorinated sulfonates and their Schiff bases as anti-Alzheimer drug candidates: An in vitro-in silico study

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141474 - 141474

Опубликована: Янв. 1, 2025

Язык: Английский

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Fluorine in the pharmaceutical industry: Synthetic approaches and application of clinically approved fluorine-enriched anti-infectious medications

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 271, С. 116446 - 116446

Опубликована: Апрель 26, 2024

Язык: Английский

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Controllable Fluorocarbon Chain Elongation: TMSCF₂Br-Enabled Trifluorovinylation and Pentafluorocyclopropylation of Aldehydes

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(3), С. 1806 - 1812

Опубликована: Янв. 9, 2024

Controllable fluorocarbon chain elongation (CFCE) is a promising yet underdeveloped strategy for the well-defined synthesis of structurally novel polyfluorinated compounds. Herein, direct and efficient trifluorovinylation pentafluorocyclopropylation aldehydes are described by using TMSCF

Язык: Английский

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High‐Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem‐Difluorinated Cyclopropanes

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 9, 2024

Abstract Transition‐metal (TM) catalyzed reaction of gem ‐difluorinated cyclopropanes ( ‐DFCPs) has drawn much attention recently. The generally occurs via the activation distal C─C bond in ‐DFCPs by a low‐valent TM through oxidative addition, eventually producing mono‐fluoro olefins as coupling products. However, achieving regioselective proximal that overcomes intrinsic reactivity catalysis remains elusive. Here, new mode enabled high‐valent copper catalysis, which allows exclusive congested is presented. achieves fluoroarylation uses NFSI (N‐fluorobenzenesulfonimide) electrophilic fluoro reagent and arenes C─H nucleophiles, enabling synthesis diverse CF 3 ‐containing scaffolds. It proposed species plays an important role possibly σ‐bond metathesis.

Язык: Английский

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A ratiometric fluorescent probe with 1,2,4-triazole recognition unit for fluoride ion detection based on synchronous fluorescence spectroscopy

Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 138108 - 138108

Опубликована: Март 20, 2024

Язык: Английский

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Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(18)

Опубликована: Март 6, 2024

Abstract Acyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl chlorides. This study delves into the properties and reactivity fluorides, particularly reaction with amines alcohols, to elucidate distinct characteristics. We also introduce facile practical synthesis from stable solution CF 3 O − salt. Additionally, we establish an efficient one‐pot process for direct preparation amides or esters corresponding acids showcasing remarkable efficiency these transformations.

Язык: Английский

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A ratiometric fluorescent dark box and smartphone integrated portable sensing platform based on hydrogen bonding induction for on-site determination of enrofloxacin

Food Chemistry, Год журнала: 2024, Номер 455, С. 139876 - 139876

Опубликована: Май 28, 2024

Язык: Английский

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Electrochemical Fluorination of Organic Compounds Using a Hexafluorosilicate Salt as an Inexpensive and Widely Available Fluorine Source

Organic Letters, Год журнала: 2025, Номер 27(4), С. 1084 - 1088

Опубликована: Янв. 20, 2025

The introduction of fluorine into organic molecules is the utmost importance in preparation active pharmaceutical ingredients (APIs). While a wide range sources for synthesis have been used over past decades, associated safety risks, cost, or environmental impact are still serious limitations. Hexafluorosilicate salts one most inexpensive and readily available nucleophilic fluorine, but they so far not synthesis. Herein we report first example use hexafluorosilicate salt as reagent formation C-F bonds. We selected model reaction an electrochemical decarboxylative fluorination procedure. bis(5-ethyl-2-methylpyridin-1-ium) hexafluorosilicate(IV) was key to obtaining soluble reactive salt. This protocol enabled primary, secondary, tertiary aliphatic fluorides (22 examples) up 85% yield. method also successfully transferred flow electrolysis cell, demonstrating its robustness scalability. Finally, extended scope source by applicability benzylic C-H fluorination.

Язык: Английский

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Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

JACS Au, Год журнала: 2025, Номер 5(2), С. 684 - 692

Опубликована: Фев. 2, 2025

Herein, we report a scalable and mild strategy for the monofluoroalkylation of wide array Giese acceptors via visible-light-mediated photoredox catalysis in continuous flow. The use flow technology significantly enhances productivity scalability, whereas mildness conditions functional group tolerance are ensured by leveraging 4CzIPN, transition-metal-free organic photocatalyst. Structurally diverse secondary tertiary monofluoroalkyl radicals can thus be accessed from readily available α-monofluorocarboxylic acids. Given reaction conditions, this protocol is also amenable to late-stage functionalization biologically relevant molecules such as menthol, amantadine, bepotastine, estrone derivatives, rendering it suitable application drug discovery programs, which introduction fluorinated fragments highly sought after. This method was extended enable reductive multicomponent radical-polar crossover transformation rapidly increase complexity assembled architectures single synthetic operation.

Язык: Английский

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Trifluoromethylation on a Nucleoside Sugar Scaffold: Design and Synthesis of 6′-Trifluoromethylcyclopentenyl-purine and -pyrimidine Nucleosides

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Based on the promising biological activity of 6′-fluorocyclopentenyl-cytosine and -adenine, we report design synthesis 6′-trifluoromethylcyclopentenyl-pyrimidine -purine as potential antiviral agents. The introduction a trifluoromethyl (CF3) group onto sugar scaffold has been achieved using methyl fluorosulfonyldifluoroacetate (Chen's reagent) key step. resulting trifluoromethylated intermediate provides an efficient pathway for synthesizing various nucleoside analogues, facilitating expansion structure–activity relationship studies neplanocin A analogues.

Язык: Английский

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