PARP7 as a new target for activating anti-tumor immunity in cancer

EMBO Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract ADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition chain (PARylation) or single moiety (MARylation) ADP-ribose to their substrates. PARP7 is mono-ADP-ribosyl transferase (mono-ART) has recently gained attention due its emerging role as negative regulator type I interferon (IFN-I) and nuclear receptor signaling, aberrant expression in cancer, contributing disease progression immune evasion. PARP7-mediated ADP-ribosylation can differentially affect protein stability. On one hand, transcription factor FRA1 protects it from proteosomal degradation thereby supports function negatively regulating IRF1 apoptosis signaling genes. other aryl hydrocarbon (AHR) estrogen (ER) marks them for degradation. also ADP-ribosylates ligand-bound androgen (AR), recognized by DTX3L-PARP9 that modulate AR transcriptional activity. In this review, we discuss enzymatic properties, biological functions known substrates, various cancers, targeting specific inhibitors.

Язык: Английский

Discovery of highly potent PARP7 inhibitors for cancer immunotherapy

Bioorganic Chemistry, Год журнала: 2024, Номер 148, С. 107469 - 107469

Опубликована: Май 17, 2024

Язык: Английский