Diversified applications and synthesis of hydroxamic acids DOI
Yao Li, Junzhou Li, Chun Cai

и другие.

Australian Journal of Chemistry, Год журнала: 2024, Номер 77(12)

Опубликована: Дек. 6, 2024

Owing to the ability form coordination complexes with several metal ions, hydroxamic acids have been widely used in fields of medicinal chemistry, mineral flotation, metal–organic frameworks (MOFs), remediation contamination and more. Since three acid-based histone deacetylase (HDAC) inhibitors were approved by US Food Drug Administration (FDA) for treatment haematologic malignancies, such functional groups acquired even more attention synthetic chemistry. However, application ore beneficiation is a unique area has attracted few researchers. In order provide insights chemists drug development, chelating collector selection, pollution preparation MOFs, we summarize applications above-mentioned fields, then introduce some related synthesis strategies including microwave synthesis, use continuous flow reactors, solid-phase enzymatic as supplements classical methods.

Язык: Английский

Heterocycles‐Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years DOI Creative Commons
A. Russo Raucci, Carola Castiello, Antonello Mai

и другие.

ChemMedChem, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Abstract Cancer is one of the primary causes mortality worldwide. Despite nowadays are numerous therapeutic treatments to fight tumor progression, it still challenging completely overcome it. It known that Histone Deacetylases (HDACs), epigenetic enzymes remove acetyl groups from lysines on histone's tails, overexpressed in various types cancer, and their inhibition represents a valid strategy. To date, some HDAC inhibitors have achieved FDA approval. Nevertheless, several other potential drug candidates been developed. This review aims primarily be comprehensive studies done so far regarding bearing heterocyclic rings since well has gained increasing interest recent years. Hence, inserting moieties HDAC‐inhibiting scaffold can valuable strategy provide potent and/or selective compounds. Here, addition summarizing properties novel inhibiting compounds, we also ideas for developing new, more potent, compounds treating cancer.

Язык: Английский

Процитировано

4
A promising future for breast cancer therapy with hydroxamic acid-based histone deacetylase inhibitors DOI

Tanima Das,

Sunandita Bhar,

Diya Ghosh

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 156, С. 108169 - 108169

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
Hydroxamic and Poly(hydroxamic acids): A State-of-the-Art Review of Their Multifaceted Applications DOI

Rawda Maen Sunoqrot,

Mohamad Hamdi Zainal-Abidin, Chen Qian

и другие.

Materials Today Communications, Год журнала: 2025, Номер unknown, С. 111751 - 111751

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors DOI Creative Commons
Dandan Yuan, Yali Gao, Lin Xia

и другие.

Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 6, 2025

Herein, we firstly reported a series of biphenyl compounds bearing hydroxamic acid moiety as PD-L1/class I HDACs dual inhibitors. Among them, compound 14 displayed the strongest inhibitory activity in vitro against HDAC2 and HDAC3 with IC50 values 27.98 nM 14.47 nM, had an value 88.10 for PD-1/PD-L1 interaction. Importantly, could upregulate expression PD-L1 CXCL10 low-expression cancer cell line (MCF-7), highlighting potential to enhance efficacy by recruiting T-cell infiltration into TME improving response inhibitor associated low-expression. Besides, identified another compound, 22, which possessed interaction 12.47 effectively inhibited proliferation three lines. Our results suggest that 22 can be served lead inhibitors further optimisation.

Язык: Английский

Процитировано

0
Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies DOI Open Access

Ziqian Huang,

Ling Li, Binbin Cheng

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117218 - 117218

Опубликована: Июль 30, 2024

Histone deacetylase 6 (HDAC6) plays a crucial role in the initiation and progression of various cancers, as its overexpression is linked to tumor growth, invasion, migration, survival, apoptosis, angiogenesis. Therefore, HDAC6 has emerged an attractive target for anticancer drug discovery past decade. However, development conventional inhibitors been hampered by their limited clinical efficacy, acquired resistance, inability inhibit non-enzymatic functions HDAC6. To overcome these challenges, new strategies, such dual-acting inhibitors, targeted protein degradation (TPD) technologies (including PROTACs, HyT), are essential enhance activity inhibitors. In this review, we focus on recent advances design modulators, including isoform-selective HDAC6-based dual-target degraders (PROTACs, from perspectives rational design, pharmacodynamics, pharmacokinetics, status. Finally, discuss challenges future directions cancer therapy.

Язык: Английский

Процитировано

3
Stimuli-Responsive Prodrugs with Self-Immolative Linker for Improved Cancer Therapy DOI

Xu Wenting,

Ang Jia,

Zhixian Lei

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116928 - 116928

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

3
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole Cap DOI Creative Commons
Han Zhang, Qianqian Shen, Hu Zhu

и другие.

Molecules, Год журнала: 2024, Номер 29(19), С. 4653 - 4653

Опубликована: Сен. 30, 2024

Drawing inspiration from the structural resemblance between a natural product

Язык: Английский

Процитировано

0
Diversified applications and synthesis of hydroxamic acids DOI
Yao Li, Junzhou Li, Chun Cai

и другие.

Australian Journal of Chemistry, Год журнала: 2024, Номер 77(12)

Опубликована: Дек. 6, 2024

Owing to the ability form coordination complexes with several metal ions, hydroxamic acids have been widely used in fields of medicinal chemistry, mineral flotation, metal–organic frameworks (MOFs), remediation contamination and more. Since three acid-based histone deacetylase (HDAC) inhibitors were approved by US Food Drug Administration (FDA) for treatment haematologic malignancies, such functional groups acquired even more attention synthetic chemistry. However, application ore beneficiation is a unique area has attracted few researchers. In order provide insights chemists drug development, chelating collector selection, pollution preparation MOFs, we summarize applications above-mentioned fields, then introduce some related synthesis strategies including microwave synthesis, use continuous flow reactors, solid-phase enzymatic as supplements classical methods.

Язык: Английский

Процитировано

0