Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101149 - 101149
Опубликована: Июль 9, 2024
Renal
cell
carcinoma
(RCC)
is
recognized
as
one
of
the
three
primary
malignant
tumors
affecting
urinary
system,
posing
a
significant
risk
to
human
health
and
life.
Despite
advancements
in
understanding
RCC,
challenges
persist
its
diagnosis
treatment,
particularly
early
detection
due
issues
low
specificity
sensitivity.
Consequently,
there
an
urgent
need
for
development
effective
strategies
enhance
diagnostic
accuracy
treatment
outcomes
RCC.
In
recent
years,
with
extensive
research
on
materials
applications
biomedical
field,
some
have
been
identified
promising
clinical
applications,
e.g.,
many
tumors,
including
Herein,
we
summarize
latest
that
are
being
studied
applied
While
focusing
their
adjuvant
effects,
also
discuss
technical
principles
safety,
thus
highlighting
value
potential
application.
addition,
limitations
application
these
possible
future
directions,
providing
new
insights
improving
RCC
treatment.
RSC Advances,
Год журнала:
2024,
Номер
14(41), С. 30201 - 30229
Опубликована: Янв. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
with
multifactorial
etiology
and
intricate
pathogenesis.
In
RA,
repeated
monotherapy
frequently
associated
inadequate
efficacy,
drug
resistance,
severe
side
effects.
Therefore,
a
shift
has
occurred
in
clinical
practice
toward
combination
therapy.
However,
conventional
therapy
encounters
several
hindrances,
including
low
selectivity
to
arthritic
joints,
short
half-lives,
varying
pharmacokinetics
among
coupled
drugs.
Emerging
nanotechnology
offers
incomparable
opportunity
for
developing
advanced
against
RA.
First,
it
allows
co-delivering
multiple
drugs
augmented
physicochemical
properties,
targeted
delivery
capabilities,
controlled
release
profiles.
Second,
enables
therapeutic
nanomaterials
development,
thereby
expanding
regimens
include
multifunctional
nanomedicines.
Lastly,
facilitates
the
construction
of
all-in-one
nanoplatforms
assembled
modalities,
such
as
phototherapy,
sonodynamic
therapy,
imaging.
Thus,
promising
solution
current
bottleneck
both
RA
treatment
diagnosis.
This
review
summarizes
rationale,
advantages,
recent
advances
nano-empowered
It
also
discusses
safety
considerations,
drug–drug
interactions,
potential
translation.
Additionally,
provides
design
tips
outlook
on
future
developments
The
objective
this
achieve
comprehensive
understanding
mechanisms
underlying
unlock
maximum
nanotechnology,
facilitating
smooth
transition
research
findings
from
laboratory
practice.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2317 - 2340
Опубликована: Март 1, 2024
Abstract:
Therapeutics
based
on
proteins
and
peptides
have
profoundly
transformed
the
landscape
of
treatment
for
diseases,
from
diabetes
mellitus
to
cancers,
yet
short
half-life
low
bioavailability
therapeutic
hinder
their
wide
applications.
To
break
through
this
bottleneck,
biomolecules-loaded
polymersomes
with
strong
adjustability
versatility
attracted
more
attentions
recently.
Loading
or
into
is
first
but
extremely
important
step
towards
developing
high-quality
formulation
products.
However,
increasing
protein
peptide
loading
content
quite
challenging
due
inherent
nature
self-assembled
vesicle
formation
mechanism
physiochemical
characteristics
biomacromolecules.
This
review
highlights
potential
as
next-generation
carrier
emphatically
introduces
novel
approaches
recent
progress
achieve
satisfactory
encapsulation
capability
peptides.
On
one
hand,
help
intermolecular
interactions,
such
electrostatic,
lipid–protein,
hydrophobic
drug
could
be
significantly
improved.
other
improvement
attained
innovation
preparation
methods,
ranging
modified
traditional
film
hydration
techniques
phase-guided
assembly
method.
Keywords:
protein,
peptide,
polymersomes,
vesicles,
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3157 - 3157
Опубликована: Март 9, 2024
A
chemo-drug
such
as
cisplatin
is
effective
for
cancer
treatment
but
remains
non-specific,
susceptible
to
drug
resistance,
and
induces
several
side
effects
on
organ
systems.
Zeolitic
imidazolate
framework-8,
a
type
of
MOF,
has
gained
attention,
including
delivery
method
targeted
therapeutics.
In
this
study,
ZIF-8/Silica
nanocomposite
was
synthesized
using
one-pot
hydrothermal
technique
the
Stober
technique.
We
studied
effect
phyto-synthesized
GPt
CPt
efficacy
therapy.
The
texture,
morphology,
chemical
environment
Pt
were
analyzed
different
characterization
techniques
XRD,
FT-IR,
BET,
diffuse
reflectance
spectroscopy,
SEM-EDX,
TEM,
zeta
potential,
TGA
analysis.
isothermal
behavior
adsorption
investigated
isotherm
models
like
Langmuir,
Freundlich,
Temkin
isotherm.
kinetics
indicating
efficiency
are
influenced
by
concentration
complex
sites
ZIF-8/Silica.
high
entrapment
loading
capacity
(86%
4.3%)
(91%
4.5%)
evident
showed
pH-sensitive
release
dialysis
membrane
For
instance,
(93%)
observed
under
pH
=
6.6
in
72
h,
while
reduced
50%
at
7.4
h.
anti-cancer
activity
nanoformulations
vitro
MCF7
(breast
cells)
HFF-1
(human
foreskin
fibroblast)
cells.
findings
demonstrated
that
CPt;
EC50
value
cells
treated
with
ZIF-8/Silica/Cp/PEG
94.86
µg/mL,
whereas
ZIF-8/Silica/GPt/PEG
it
60.19
µg/mL.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 202 - 202
Опубликована: Янв. 16, 2024
Peptide-functionalized
nanomedicine,
which
addresses
the
challenges
of
specificity
and
efficacy
in
drug
delivery,
is
emerging
as
a
pivotal
approach
for
cancer
therapy.
Globally,
remains
leading
cause
mortality,
conventional
treatments,
such
chemotherapy,
often
lack
precision
adverse
effects.
The
integration
peptides
into
nanomedicine
offers
promising
solution
enhancing
targeting
delivery
therapeutic
agents.
This
review
focuses
on
three
primary
applications
peptides:
cell-targeting
ligands,
building
blocks
self-assembling
nanostructures,
elements
stimuli-responsive
systems.
Nanoparticles
modified
with
improved
cells,
minimized
damage
to
healthy
tissues,
optimized
delivery.
versatility
self-assembled
peptide
structures
makes
them
an
innovative
vehicle
by
leveraging
their
biocompatibility
diverse
nanoarchitectures.
In
particular,
mechanism
cell
death
induced
novel
addition,
systems
enable
precise
release
response
specific
conditions
tumor
microenvironment.
use
not
only
augments
safety
treatments
but
also
suggests
new
research
directions.
this
review,
we
introduce
functionalization
methods
using
or
peptide-modified
nanoparticles
overcome
treatment
cancers,
including
breast
cancer,
lung
colon
prostate
pancreatic
liver
skin
glioma,
osteosarcoma,
cervical
cancer.
