Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106650 - 106650
Опубликована: Дек. 26, 2024
Язык: Английский
Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110413 - 110413
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Food Hydrocolloids for Health, Год журнала: 2025, Номер 7, С. 100221 - 100221
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0
Metabolic Brain Disease, Год журнала: 2025, Номер 40(5)
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0
Foods, Год журнала: 2024, Номер 13(16), С. 2552 - 2552
Опубликована: Авг. 16, 2024
Developing of functional foods is a promising strategy to reduce the increasing burden colorectal cancer worldwide. Fruit pomace, particularly polyphenol and anthocyanin-rich chokeberry blueberry, valuable ingredient for nutraceuticals. Our study aimed evaluate anti-inflammatory antiproliferative effects blueberry pomace extracts on C2BBe1 carcinoma cells explore underlying signaling pathways. We analyzed both total polyphenols anthocyanins using Folin-Ciocalteu method ultra-performance liquid chromatography, while antioxidative activity was assessed via 2,2-diphenyl-1-picrylhydrazyl radical scavenging method. evaluated in vitro trypan blue exclusion, MTT LDH assays, protein levels p-Erk1/2, Akt-1, STAT1, STAT3, occludin, oxidized proteins, MDA-protein adducts through western blotting, as well analysis 37-plex panel inflammatory markers. Chokeberry exhibited higher content, anthocyanin levels, compared extracts, however, cell viability proliferation were stronger. Both fruit pomaces induced non-inflammatory death characterized by membrane integrity loss, beneficial therapy. data suggests chokeberry’s cytotoxicity may be mediated Erk Akt-1 inhibition, uniquely decreased occludin levels. These berries pomaces’ potential mitigate risks enhance treatment efficacy promising, warranting further investigation development.
Язык: Английский
Процитировано
3
Environmental Pollution, Год журнала: 2024, Номер 352, С. 124128 - 124128
Опубликована: Май 8, 2024
Язык: Английский
Процитировано
1
iScience, Год журнала: 2024, Номер 27(11), С. 111109 - 111109
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
1
Discover Immunity., Год журнала: 2024, Номер 1(1)
Опубликована: Ноя. 14, 2024
Immunosuppressive agents are crucial for managing autoimmune diseases and organ transplants, but synthetic options often cause significant side effects. Nigerian medicinal plants, rich in bioactive compounds, present a promising natural alternative immune modulation. This systematic review examines the immunosuppressive properties of phytochemicals phytonutrients from focusing on their mechanisms action therapeutic potential. A comprehensive literature search was conducted following PRISMA guidelines across major databases, including PubMed, Scopus, Google Scholar, Cochrane Library, Web Science, AJOL. The covered studies published between January 2000 August 2024 using keywords like "immunosuppressive," "phytochemicals," "phytonutrients," specific plants. Studies were included if they investigated effects plants through vitro, vivo, or clinical methods. Non-immunological excluded. Data extraction quality assessment independently performed by two reviewers. total 141 reviewed, identifying several with notable Azadirachta indica (neem) demonstrated strong ability to inhibit T-cell proliferation cytokine production. Vernonia amygdalina (bitter leaf) Garcinia kola kola) effective reducing pro-inflammatory cytokines modulating lymphocyte activity. Other Ocimum gratissimum (scent leaf), Allium sativum (garlic), Zingiber officinale (ginger), exhibited regulating release cell activation. These findings suggest that offer diverse agents, working inhibition signaling pathway highlights potential as encouraging further research explore applications integration into current treatment frameworks. Future trials essential validate efficacy safety, uses disease management, inflammatory conditions, transplantation.
Язык: Английский
Процитировано
1
Medycyna Weterynaryjna, Год журнала: 2024, Номер 80(05), С. 6876 - 2024
Опубликована: Янв. 1, 2024
Detailed information on the in vivo activity of vegetal extracts immune system birds and mammals, mainly farmed ones, is helpful improving their resilience welfare. Therefore there need to investigate exact roles active plant components animals, influence system, which crucial for antimicrobial resistance. The farming serving principally economic aims, overlooks physiological support several extremely stress-sensitive, short-lived species such as chickens or rabbits. Recovering from damage caused by adverse microclimates nutritional deficiencies these can be a prolonged process often standing beyond lifespan. Additionally, compromised condition makes them susceptible various diseases, particularly microbial parasitic infections easily take hold weakened state. Under circumstances, it seems very important select study natural enhancers response. Setting up optimal therapeutic protocols establishing age range administration route boost effects. vitro tests, performed isolated cell- cell-line cultures, proved beneficial certain extracts, diminished oxidative stress tumor growth, well overcame negative effects oxygen species, increasing synthesis cytokines. aimed a) establish potential dose-effect relationship selected b) considering that belonging either groups Aves Mammalia changes response extracts. Blood samples taken hens rabbits were subjected blast transformation tests (RPMI 1640 culture medium, 48 hours incubation 5% CO2 atmosphere) estimate alcoholic Calendula officinalis, Vaccinum myrtilus, Echinacea purpurea, Hippophae rhamnoides at 1.5% 6.5% concentrations colorimetric assay (orto-toluidine test). results indicated maximal stimulation indices, reverse dose-dependent manner, myrtillus (81.93 ± 18.74% concentration) officinalis (74.70 22.15% concentration). In rabbits, all had stimulating effects, (80.72 6.82% (68.67 17.04% being more effective than (65.06 35.78% Obviously, depended phylogeny animal origin. Thus, reacted an inversely while directly dose-dependent. highlight importance preliminary selecting appropriate extract stimulation/modulation given animals.
Язык: Английский
Процитировано
0
Separations, Год журнала: 2024, Номер 11(8), С. 220 - 220
Опубликована: Июль 23, 2024
Phyllostachys glauca McClure leaves (PML), as economical natural product material, contain abundant phenols, particularly flavonoids, with significant biological activities that contribute to their widespread applications in food, pharmaceutical, and cosmetic industries. To study the phenols PML, an ultrasound-assisted deep eutectic solvent extraction method high efficiency low toxicity was established for extracting from PML bamboo of 17 other species. Using Ultra Performance Liquid Chromatography (UPLC) method, content 18 species determined. were found neochlorogenic acid, chlorogenic cryptochlorogenic isoorientin, orientin at contents 0.793 ± 00.17 mg/g, 0.491 0.0081 0.485 0.0043 0.465 0.0021 0.044 0.0005 respectively, a total 2.278 mg/g. These significantly higher than those Additionally, acid simultaneously 15 species, especially PML. Therefore, can be viewed material considerable application values, owing its exhibit importance utilizing resources.
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106650 - 106650
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
0