Peptides derived from casein hydrolyzed by Lactobacillus: Screening and antioxidant properties in H2O2-induced HepG2 cells model

Journal of Functional Foods, Год журнала: 2024, Номер 117, С. 106221 - 106221

Опубликована: Май 7, 2024

Protein hydrolysates and peptides in fermented dairy products exhibit antioxidant activities. This study aimed to evaluate the properties of casein whey protein derived from three lactic acid bacteria. The assessment involved observation Reactive oxygen species (ROS), Malondialdehyde (MDA) content, Superoxide dismutase (SOD), Catalase (CAT), cell morphology chromatin H2O2 induced HepG2 model. Casein hydrolyzed by Lactobacillus reuteri exhibited higher activity. ROS content decreased 44.7 %, while SOD CAT activities increased 48 % 194 respectively. Furthermore, it was confirmed that peptide VKEAMAPK reuteri's hydrolysate possessed significant potential. docking analysis Keap1 showed they were stably bound outside Kelch domain formed a non-competitive inhibition effect. Additionally, this lights on milk-derived screened hydrolysates.

Язык: Английский

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Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107571 - 107571

Опубликована: Янв. 1, 2025

Diverse liver diseases are characterised by late diagnosis and rapid progression have become one of the major threats to human health. To delay transition from benign tissue lesions a substantial organ injury, scientists gradually applied natural compounds derived plants as complementary therapy in field hepatology. Ginseng (Panax ginseng C. A. Meyer) is tonic traditional Chinese herbal medicine, products, including ginsenoside Rg1 (G-Rg1), which kind 20(S)-protopanaxatriol saponin with relatively high biological activity, can be isolated roots or stems ginseng. Given these information, this review aimed summarise discuss metabolic mechanisms G-Rg1 regulation diverse measures improve its bioavailability. As monomer medicine multitarget pharmacological effects, provide significant therapeutic benefits alleviation alcoholic disease, nonalcoholic fatty fibrosis, viral hepatitis, etc., mainly rely on inhibition apoptosis, strengthening endogenous anti-inflammatory antioxidant mechanisms, activation immune responses efflux transport signals, pathological changes caused lipid deposition, inflammation, oxidative stress, accumulation hepatotoxic product, etc. However, poor bioavailability must overcome clinical application value. In summary, focusing hepatoprotective will new insights into development resources their pharmaceutical products target treatment diseases.

Язык: Английский

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Anti-inflammatory and antioxidant effects of baicalein: targeting Nrf2, and NFĸB in neurodegenerative disease

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

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Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach

Foods, Год журнала: 2024, Номер 13(13), С. 1960 - 1960

Опубликована: Июнь 21, 2024

Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such metabolic syndrome type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day (ADF) or time-restricted feeding (TRF), was compared with approach. We evaluated different roles of IF treating human disorders syndrome, diabetes, some types cancer, well usefulness reducing cardiovascular risk factors hypertension. Furthermore, explored cellular pathways targeted exert their beneficial effects activating effector proteins that modulate cell functions resistance oxidative stress. contrast, investigated concerns regarding health related adoption regimens, highlighting profound debate surrounding loss regimens. examined several trials formulate an updated concept its therapeutic potential.

Язык: Английский

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Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of Ischemic stroke

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117506 - 117506

Опубликована: Март 13, 2025

Язык: Английский

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Green Tea Polyphenol Epigallocatechin-3-gallate Mediates an Antioxidant Response via Nrf2 Pathway in Heat-Stressed Poultry: A Review

Poultry Science, Год журнала: 2025, Номер 104(5), С. 105071 - 105071

Опубликована: Март 20, 2025

Heat stress is a critical challenge in the poultry industry. It arises when birds are exposed to elevated ambient temperatures beyond their thermoneutral zone, often exacerbated by high humidity and inadequate ventilation. This condition disrupts birds' ability maintain thermal homeostasis, leading physiological behavioral changes such as increased panting, reduced feed intake, water consumption. These responses aim dissipate heat but result energy imbalances, oxidative stress, impaired immune function. Green tea polyphenols (GTPs) mitigate modulating pathways, primarily scavenging reactive oxygen species (ROS) enhancing antioxidant defense mechanisms. pathways play pivotal role neutralizing ROS generated during inflammation, exposure electrophilic compounds. action helps restore cellular balance enhances overall mechanisms converting harmful free radicals into less molecules, oxygen. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays significant character activation of enzymatic antioxidants network. translocates nucleus upon activation, binds response elements (AREs) promoter regions target genes, upregulates expression key enzymes. Therefore, regulation Nrf2 considered molecular marker mitigating effects its detoxification enzymes, protecting against damage inflammation induced temperatures. exploratory review summarizes anti-oxidative GTPs poultry. highlights cytoprotective basis epigallocatechin-3-gallate (EGCG), particularly Nrf2-mediated which enhance systems protect damage.

Язык: Английский

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Neuroprotective and antioxidant potential of papaya leaf extract and its active compounds via Nrf-2 activation

Food Science and Biotechnology, Год журнала: 2025, Номер 34(11), С. 2611 - 2623

Опубликована: Апрель 2, 2025

Язык: Английский

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Effects of dietary sodium alginate and Lactobacillus reuteri on the growth, antioxidant capacity and intestinal health of largemouth bass (Micropterus salmoides)

Aquaculture Reports, Год журнала: 2025, Номер 42, С. 102811 - 102811

Опубликована: Апрель 12, 2025

Язык: Английский

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Curcumin’s role in reshaping the redox dynamics of fish kidneys: NRF2 activation as a strategy against copper-induced nephropathy

Fish Physiology and Biochemistry, Год журнала: 2025, Номер 51(3)

Опубликована: Май 7, 2025

Язык: Английский

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Structural, functional and antioxidant characteristics of enzymatic hydrolysates from Cantharellus cibarius protein

Food Chemistry, Год журнала: 2025, Номер 486, С. 144626 - 144626

Опубликована: Май 8, 2025

Язык: Английский

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