Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106564 - 106564
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106564 - 106564
Опубликована: Дек. 1, 2024
Язык: Английский
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114003 - 114003
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125380 - 125380
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0Food Chemistry, Год журнала: 2024, Номер 468, С. 142315 - 142315
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
3Journal of Inclusion Phenomena and Macrocyclic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 19, 2024
Abstract TADDOL5 possesses the ability to form complexes with heterocyclic guest species DIO, PYR, PIP and MOR, 1:1 (PYR, PIP, MOR) 2:1 (DIO) H:G inclusion compounds were isolated after host crystallization experiments from these solvents. Guest competition revealed that MOR preferred by TADDOL5, while PYR DIO less favoured; selectivity of this compound for guests was thus demonstrated be in order > DIO. SCXRD analyses explained preferential order: experienced shorter more linear (host)O‒H···N(guest) hydrogen bond followed PYR. also retained crystal complex means a (host)O‒H···O(guest) type. Hirshfeld surface investigations did not provide further understanding behaviour when crystallized mixed guests, but relative thermal stability formed most stable least favoured, characterised lowest stability. Graphical abstract
Язык: Английский
Процитировано
1Current Drug Metabolism, Год журнала: 2024, Номер 25(8), С. 547 - 553
Опубликована: Дек. 30, 2024
The well-established calcineurin inhibitor, tacrolimus, as an immunosuppressive agent, is widely prescribed after organ transplantation. Cytochrome P450 (CYP 450) isoforms are responsible for the metabolism of many features associated with food parameters like phytochemicals, juices, and fruits. This review article summarizes findings previous studies to help predict efficacy or side effects tacrolimus in presence variables. From commencement databases topic interest 26 October 2024, all relevant articles were searched through PubMed, Scopus, Web Science. suggested therapeutic range trough concentration (C<sub>0</sub> ) was reported 5-15 ng/ml blood. Tacrolimus interaction variables could significantly change C<sub>0</sub> For example, grapefruit juice increase due CYP enzyme inhibition. Toxicity such nephrotoxicity result from turmeric other herbal products. By inhibiting tacrolimus-metabolizing enzymes transporters, a high intake vegetables risk adverse effects. Secondary metabolites lead toxicity patients tacrolimus. Furthermore, juice, citrus fruits, turmeric, pomegranate clinical pharmacokinetics T<sub>max</sub>, C<sub>max</sub>, AUC, Bioavailability might be decreased by induction CYP450 system P-gp efflux pump cranberry, rooibos tea, boldo. Increased inhibitory effect on and/or schisandra, berberine, pomelo, ginger bioavailability A vigilant strategy accompanied scheduled drug monitoring recommended before transplant surgery.
Язык: Английский
Процитировано
1Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 19, 2024
Язык: Английский
Процитировано
0Transition Metal Chemistry, Год журнала: 2024, Номер 50(1), С. 115 - 125
Опубликована: Сен. 16, 2024
Язык: Английский
Процитировано
0Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106564 - 106564
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0