Sulfur- and phosphorus-containing FDA approved drugs in the last five years (2020–2024): A journey among small molecules
Phosphorus, sulfur, and silicon and the related elements,
Год журнала:
2025,
Номер
unknown, С. 1 - 39
Опубликована: Апрель 25, 2025
Язык: Английский
Exploration of 1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives effect on triple-negative breast, prostate cancer and melanoma cell 2D and 3D cultures
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 21, 2025
1-Substituted
5-oxopyrrolidine-3-carboxylic
acid
and
its
derivatives
play
an
important
role
as
components
of
many
biologically
active
molecules.
This
study
describes
the
synthesis
1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic
their
anticancer
properties.
The
target
compounds
were
prepared
using
2,4-difluoroniline
a
starting
material;
in
this
way,
benzimidazoles,
hydrazones
azoles
formed.
Investigation
activity
all
synthesized
showed
that
had
strongest
effect
on
cancer
cell
lines.
Compounds
tested
for
cytotoxic
by
MTT
assay
human
triple-negative
breast
MDA-MB-231,
prostate
adenocarcinoma
PPC1,
melanoma
A375
foreskin
fibroblasts
CRL-4001
after
72
hours
incubation.
impact
migration
was
assessed
'wound
healing
assay'.
Activity
3D
cultures
determined
evaluating
changes
spheroid
size
assessing
viability.
Overall,
selected
7b,
9c,
9e,
9f
10
exhibited
greater
line
less
against
MDA-MB-231
line.
9e
relatively
higher
selectivity
cells
over
fibroblasts.
Hydrazone
9f,
bearing
N'-(4-methylbenzylidene)
moiety,
identifiedasthe
most
compound
both
PPC-1
monolayer
culture
models.
Compound
with
N'-(4-bromobenzylidene)
pronounced
inhibitory
healing'
assay.
Язык: Английский
Synthesis, Structure, and Properties of a Copper(II) Binuclear Complex Based on Trifluoromethyl Containing Bis(pyrazolyl)hydrazone
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9414 - 9414
Опубликована: Авг. 30, 2024
A
new
complex
of
copper(II)
with
methyl-5-(trifluoromethyl)pyrazol-3-yl-ketazine
(H2L)
was
synthesized
the
composition
[Cu2L2]∙C2H5OH
(1).
Recrystallization
sample
from
DMSO
yielded
a
single
crystal
[Cu2L2((CH3)2SO)]
(2).
The
coordination
compounds
were
studied
by
single-crystal
X-ray
diffraction
analysis,
IR
spectroscopy,
and
static
magnetic
susceptibility
method.
data
obtained
indicate
that
polydentate
ligand
is
coordinated
both
acyclic
nitrogen
heterocyclic
atoms.
cytotoxic
activity
1
investigated
on
human
cell
lines
MCF7
(breast
adenocarcinoma),
Hep2
(laryngeal
carcinoma),
A549
(lung
HepG2
(hepatocellular
MRC5
(non-tumor
lung
fibroblasts).
shown
to
have
pronounced
dose-dependent
cytotoxicity
towards
these
LC50
values
in
range
0.18–4.03
μM.
Язык: Английский