Recent Advances in Peptide Inhibitors Targeting Wild-Type Ras Protein Interactions in Cancer Therapy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1425 - 1425
Опубликована: Фев. 8, 2025
Ras
proteins
are
pivotal
in
the
regulation
of
cell
proliferation
signals,
and
their
dysregulation
is
intricately
linked
to
pathogenesis
various
malignancies.
Peptide
inhibitors
hold
distinct
advantages
targeting
proteins,
attributable
extensive
binding
domains,
which
result
from
smooth
surfaces
proteins.
The
array
specific
strategies
includes
employment
full
hydrocarbon
chains,
cyclic
peptides,
linear
N-terminal
nucleation
polypeptides.
These
methods
effectively
suppress
signaling
pathway
through
mechanisms,
highlighting
potential
as
anti-neoplastic
agents.
Moreover,
cutting-edge
methodologies,
including
aspartate
strategy
utilization
hydrocarbon-stapled
transforming
landscape
therapeutics
aimed
at
innovations
highlight
promise
peptide
libraries
combinatorial
chemistry
augmenting
affinity,
specificity,
cellular
permeability,
for
development
potent
anti-cancer
incorporation
dual
therapeutic
strategies,
such
synergy
between
conventional
chemotherapy
or
use
radiotherapy
enhancers,
emerges
a
compelling
bolster
efficacy
cancer
treatments
Ras-MAPK
pathway.
Furthermore,
recent
studies
have
demonstrated
that
Ras-targeting
stabilized
peptides
can
amplify
radio-sensitivity
cells,
offering
an
innovative
approach
enhance
radiation
therapy
within
management.
Язык: Английский
Design, Synthesis, and Antitumor Activity of Stapled Peptide Inhibitors Targeting the RAS–RAF Interactions
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 117568 - 117568
Опубликована: Март 1, 2025
Язык: Английский
Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13212 - 13212
Опубликована: Дек. 9, 2024
Alzheimer's
disease
(AD),
a
leading
neurodegenerative
disorder,
is
closely
associated
with
the
accumulation
of
amyloid-beta
(Aβ)
peptides
in
brain.
The
enzyme
β-secretase
(BACE1),
pivotal
Aβ
production,
represents
promising
therapeutic
target
for
AD.
While
bioactive
derived
from
food
protein
hydrolysates
have
neuroprotective
properties,
their
inhibitory
effects
on
BACE1
remain
largely
unexplored.
In
this
study,
we
evaluated
potential
gliadin,
whey,
and
casein
proteins
prepared
using
bromelain,
papain,
thermolysin.
Through
vitro
cellular
assays,
bromelain-hydrolyzed
gliadin
(G-Bro)
emerged
as
most
potent
inhibitor,
an
IC
Язык: Английский