Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease DOI Open Access
Ji Su Hwang, Seok Gi Kim,

Nimisha Pradeep George

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13260 - 13260

Опубликована: Дек. 10, 2024

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) considered most suited source for investigating PD pathogenesis and identifying biomarkers. While microRNA (miRNA) profiling can aid investigation of post-transcriptional regulation diseases, information on miRNAs CSF patients with remains limited. This review combines miRNA analysis proteomic to explore collective impact mechanisms PD. We constructed separate networks altered proteomes using bioinformatics method. Altered were poorly linked biological functions owing limited information; however, changes protein expression strongly associated functions. Subsequently, integrated further analysis. In silico prediction from network revealed relationships between proteins, highlighting increased reactive oxygen species generation, neuronal loss, neurodegeneration suppressed ATP synthesis, mitochondrial function, neurotransmitter release The approach suggests potential as biomarkers critical underlying combined strategy could enhance our understanding complex biochemical support development diagnostic therapeutic strategies precision medicine.

Язык: Английский

The future of pharmaceuticals: Artificial intelligence in drug discovery and development DOI Creative Commons
Chen Fu, Qi Chen

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101248 - 101248

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
miR-210: A non-invasive biomarker for hypoxia-driven lung cancer diagnosis and therapy DOI
Ahsas Goyal, Muhammad Afzal,

Kavita Goyal

и другие.

Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120215 - 120215

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Pan-cancer investigation regarding the prognostic predictive and immunological regulation functions of PGK1 and experimental validation in esophageal squamous cell carcinoma DOI
Junru Chen, Xun Wu, Hongtao Luo

и другие.

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Nanotechnology and Artificial Intelligence in Cancer Treatment DOI

Yashdeep Mukheja,

Kashish Pal,

Akanksha Ahuja

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100179 - 100179

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Advancing Src Kinase Inhibition: From Structural Design to Therapeutic Innovation - A Comprehensive Review DOI

Yifeng Su,

Kun Zhu,

Jiahao Wang

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117369 - 117369

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

0
Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease DOI Open Access
Ji Su Hwang, Seok Gi Kim,

Nimisha Pradeep George

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13260 - 13260

Опубликована: Дек. 10, 2024

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) considered most suited source for investigating PD pathogenesis and identifying biomarkers. While microRNA (miRNA) profiling can aid investigation of post-transcriptional regulation diseases, information on miRNAs CSF patients with remains limited. This review combines miRNA analysis proteomic to explore collective impact mechanisms PD. We constructed separate networks altered proteomes using bioinformatics method. Altered were poorly linked biological functions owing limited information; however, changes protein expression strongly associated functions. Subsequently, integrated further analysis. In silico prediction from network revealed relationships between proteins, highlighting increased reactive oxygen species generation, neuronal loss, neurodegeneration suppressed ATP synthesis, mitochondrial function, neurotransmitter release The approach suggests potential as biomarkers critical underlying combined strategy could enhance our understanding complex biochemical support development diagnostic therapeutic strategies precision medicine.

Язык: Английский

Процитировано

1