The Role of PTP1B in Cardiometabolic Disorders and Endothelial Dysfunction DOI

Mona Sawali,

Muhammad Zahid,

Shahenda Salah Abdelsalam

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 39

Опубликована: Фев. 25, 2025

Cardiovascular diseases (CVD) are a global health concern that accounts for large share of annual mortality. Endothelial dysfunction is the main underlying factor eventually leads to cardiovascular events. Recent studies have underscored critical function Protein Tyrosine Phosphatase 1B (PTP1B) in onset endothelial dysfunction, chiefly through its involvement metabolic such as diabetes, obesity, and leptin resistance. PTP1B attenuates insulin signaling by dephosphorylating their respective receptors at key tyrosine residues, resulting resistance-both which significant mechanisms underpinning development dysfunction. also contributes disruption endoplasmic reticulum, causing reticulum stress, another molecular driver Efforts inhibit activity hold promise advancing prevention management CVD disorders, these conditions common risk factors cellular mechanisms. Numerous small molecules been reported inhibitors; however, progression advanced clinical trials has hindered major challenges low selectivity undesirable side effects. This review provides an in-depth analysis PTP1B's interaction with examines strategies related inhibiting this enzyme.

Язык: Английский

The Role of PTP1B in Cardiometabolic Disorders and Endothelial Dysfunction DOI

Mona Sawali,

Muhammad Zahid,

Shahenda Salah Abdelsalam

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 39

Опубликована: Фев. 25, 2025

Cardiovascular diseases (CVD) are a global health concern that accounts for large share of annual mortality. Endothelial dysfunction is the main underlying factor eventually leads to cardiovascular events. Recent studies have underscored critical function Protein Tyrosine Phosphatase 1B (PTP1B) in onset endothelial dysfunction, chiefly through its involvement metabolic such as diabetes, obesity, and leptin resistance. PTP1B attenuates insulin signaling by dephosphorylating their respective receptors at key tyrosine residues, resulting resistance-both which significant mechanisms underpinning development dysfunction. also contributes disruption endoplasmic reticulum, causing reticulum stress, another molecular driver Efforts inhibit activity hold promise advancing prevention management CVD disorders, these conditions common risk factors cellular mechanisms. Numerous small molecules been reported inhibitors; however, progression advanced clinical trials has hindered major challenges low selectivity undesirable side effects. This review provides an in-depth analysis PTP1B's interaction with examines strategies related inhibiting this enzyme.

Язык: Английский

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