Exploring Anticancer Activity and DNA Binding of Metal (II) Salicylaldehyde Schiff Base Complexes: A Convergence of Experimental and Computational Perspectives DOI Creative Commons
Ibrahim Waziri, Sheldon Sookai, Tunde L. Yusuf

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(5)

Опубликована: Апрель 9, 2025

ABSTRACT Metal complexes derived from salicylaldehyde‐based Schiff bases are among the frontrunners in pursuit of precise and potent cancer treatments due to their remarkable prowess. In this study, base ( HL ) was prepared via a reaction between 2‐amino‐5‐benzonitrile salicylaldehyde. Subsequently, further reacted with Ni (II), Co Cu (II) Pd ions using respective metal salts obtain homoleptic mononuclear C1 – C4 ). The composition were determined 1 H 13 C NMR, UV–Vis, FTIR, CHN, SEM–EDX HRMS analyses. addition, structural geometries , C3 solid state single crystal X‐ray diffraction analysis corroborate mentioned characterization techniques employed. stability compounds assessed through time‐dependent UV–vis spectroscopy, revealing that C2 exhibited highest under experimental conditions. anticancer effects tested on breast cell lines (MCF‐7) MTT, LDH ATP assays. Both displayed potential cytotoxicity MCF‐7 line, which better inhibition effect than standard chemotherapeutic agent, doxorubicin (DOX), IC 50 43.08 μM. We postulate mechanism by may function is binding DNA = 0.114 (± 0.02) × 10 4 intercalation (shown UV‐CD UV‐LD spectroscopy) at AT rich sites. These data corroborated silico extra precision (XP) docking molecular dynamic (MD) simulations.

Язык: Английский

Binding Thermodynamics of 1,3-bis(((E-1H-pyrrol-2-yl) methylene) amino) propan-2-ol palladium(II) with HSA and Its Intercalative Behaviour in ctDNA DOI Creative Commons
Sheldon Sookai,

Ayanda Majoka,

Manuel A. Fernandes

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер 1334, С. 141880 - 141880

Опубликована: Фев. 26, 2025

Язык: Английский

Процитировано

1
Exploring Anticancer Activity and DNA Binding of Metal (II) Salicylaldehyde Schiff Base Complexes: A Convergence of Experimental and Computational Perspectives DOI Creative Commons
Ibrahim Waziri, Sheldon Sookai, Tunde L. Yusuf

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(5)

Опубликована: Апрель 9, 2025

ABSTRACT Metal complexes derived from salicylaldehyde‐based Schiff bases are among the frontrunners in pursuit of precise and potent cancer treatments due to their remarkable prowess. In this study, base ( HL ) was prepared via a reaction between 2‐amino‐5‐benzonitrile salicylaldehyde. Subsequently, further reacted with Ni (II), Co Cu (II) Pd ions using respective metal salts obtain homoleptic mononuclear C1 – C4 ). The composition were determined 1 H 13 C NMR, UV–Vis, FTIR, CHN, SEM–EDX HRMS analyses. addition, structural geometries , C3 solid state single crystal X‐ray diffraction analysis corroborate mentioned characterization techniques employed. stability compounds assessed through time‐dependent UV–vis spectroscopy, revealing that C2 exhibited highest under experimental conditions. anticancer effects tested on breast cell lines (MCF‐7) MTT, LDH ATP assays. Both displayed potential cytotoxicity MCF‐7 line, which better inhibition effect than standard chemotherapeutic agent, doxorubicin (DOX), IC 50 43.08 μM. We postulate mechanism by may function is binding DNA = 0.114 (± 0.02) × 10 4 intercalation (shown UV‐CD UV‐LD spectroscopy) at AT rich sites. These data corroborated silico extra precision (XP) docking molecular dynamic (MD) simulations.

Язык: Английский

Процитировано

0