International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 12924 - 12924
Опубликована: Окт. 26, 2022
Alzheimer’s
disease
(AD),
is
a
progressive
neurodegenerative
that
affects
behavior,
thinking,
learning,
and
memory
in
elderly
individuals.
AD
occurs
two
forms,
early
onset
familial
late-onset
sporadic;
genetic
mutations
PS1,
PS2,
APP
genes
cause
AD,
combination
of
lifestyle,
environment
factors
causes
the
sporadic
form
disease.
However,
accelerated
progression
noticed
patients
with
AD.
Disease-causing
pathological
changes
are
synaptic
damage,
mitochondrial
structural
functional
changes,
addition
to
increased
production
accumulation
phosphorylated
tau
(p-tau),
amyloid
beta
(Aβ)
affected
brain
regions
patients.
Aβ
peptide
derived
from
precursor
protein
(APP)
by
proteolytic
cleavage
gamma
secretases.
glycoprotein
plays
significant
role
maintaining
neuronal
homeostasis
like
signaling,
development,
intracellular
transport.
reported
have
both
protective
toxic
effects
neurons.
The
purpose
our
article
summarize
recent
developments
its
association
synapses,
mitochondria,
microglia,
astrocytes,
interaction
p-tau.
Our
also
covers
therapeutic
strategies
reduce
toxicities
discusses
reasons
for
failures
therapeutics.
Marine Drugs,
Год журнала:
2021,
Номер
19(9), С. 484 - 484
Опубликована: Авг. 26, 2021
Marine
algae
are
rich
in
bioactive
nutraceuticals
(e.g.,
carbohydrates,
proteins,
minerals,
fatty
acids,
antioxidants,
and
pigments).
Biotic
plants,
microorganisms)
abiotic
factors
temperature,
pH,
salinity,
light
intensity)
contribute
to
the
production
of
primary
secondary
metabolites
by
algae.
Easy,
profitable,
sustainable
recovery
methods
include
novel
solid-liquid
liquid-liquid
extraction
techniques
supercritical,
high
pressure,
microwave,
ultrasound,
enzymatic).
The
spectacular
findings
algal-mediated
synthesis
nanotheranostics
has
attracted
further
interest
because
availability
microalgae-based
natural
therapeutic
compounds
cost-effective
commercialization
stable
microalgal
drugs.
Algal
extracts
can
serve
as
stabilizing/capping
reducing
agents
for
thermodynamically
nanoparticles
(NPs).
Different
types
nanotherapeutics
have
been
synthesized
using
physical,
chemical,
biological
methods.
a
fascinating
source
lead
theranostics
compounds,
development
linked
enhanced
drug
efficacy
safety.
Indeed,
remarkable
nanobiofactories,
their
pragmatic
properties
reside
(i)
ease
handling;
(ii)
capacity
absorb/accumulate
inorganic
metallic
ions;
(iii)
cost-effectiveness;
(iv)
eco-friendly,
rapid,
healthier
NPs.
Preclinical
clinical
trials
shall
enable
really
define
effective
algal-based
nanotherapies.
This
review
aims
provide
an
overview
main
algal
that
be
extracted
purified
nanotheranostic
purposes.
Pharmaceutics,
Год журнала:
2021,
Номер
13(5), С. 660 - 660
Опубликована: Май 5, 2021
Flavonoids
are
among
the
most
abundant
natural
bioactive
compounds
produced
by
plants.
Many
different
activities
have
been
reported
for
these
secondary
metabolites
against
numerous
cells
and
systems.
One
of
interesting
is
certainly
antimicrobial,
which
stimulated
through
various
molecular
mechanisms.
In
fact,
flavonoids
effective
both
in
directly
damaging
envelope
Gram-negative
Gram-positive
bacteria
but
also
acting
toward
specific
targets
essential
survival
microorganisms.
The
purpose
this
paper
to
present
an
overview
results
obtained
research
focused
on
study
interactions
between
bacterial
proteins.
Despite
great
structural
heterogeneity
plant
metabolites,
it
observe
that
many
affect
same
cellular
pathways.
Furthermore,
evident
some
interact
with
more
than
one
target,
producing
multiple
effects.
Taken
together,
data
demonstrate
potential
developing
innovative
systems,
can
help
address
increasingly
serious
problem
antibiotic
resistance.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Март 18, 2022
Ginger
is
composed
of
multiple
bioactive
compounds,
including
6-gingerol,
6-shogaol,
10-gingerol,
gingerdiones,
gingerdiols,
paradols,
6-dehydrogingerols,
5-acetoxy-6-gingerol,
3,5-diacetoxy-6-gingerdiol,
and
12-gingerol,
that
contribute
to
its
recognized
biological
activities.
Among
them,
the
major
active
compounds
are
6-shogaol
6-gingerol.
Scientific
evidence
supports
beneficial
properties
ginger,
antioxidant
anti-inflammatory
capacities
in
contrast,
a
specific
less
studied
bioactivity
possible
neuroprotective
effect.
The
increase
life
expectancy
has
raised
incidence
neurodegenerative
diseases
(NDs),
which
present
common
neuropathological
features
as
increased
oxidative
stress,
neuroinflammation
protein
misfolding.
structure-activity
relationships
ginger
phytochemicals
show
can
be
candidate
treat
NDs
by
targeting
different
ligand
sites.
Its
may
improve
neurological
symptoms
pathological
conditions
modulating
cell
death
or
survival
signaling
molecules.
cognitive
enhancing
effects
might
partly
explained
via
alteration
both
monoamine
cholinergic
systems
various
brain
areas.
Moreover,
decreases
production
inflammatory
related
factors.
aim
review
summarize
prevention
such
Alzheimer's
disease,
Parkinson's
disease
sclerosis.
Physiological Reviews,
Год журнала:
2023,
Номер
104(1), С. 103 - 197
Опубликована: Окт. 16, 2023
Alzheimer
disease
(AD)
is
associated
with
multiple
etiologies
and
pathological
mechanisms,
among
which
oxidative
stress
(OS)
appears
as
a
major
determinant.
Intriguingly,
OS
arises
in
various
pathways
regulating
brain
functions,
it
seems
to
link
different
hypotheses
mechanisms
of
AD
neuropathology
high
fidelity.
The
particularly
vulnerable
damage,
mainly
because
its
unique
lipid
composition,
resulting
an
amplified
cascade
redox
reactions
that
target
several
cellular
components/functions
ultimately
leading
neurodegeneration.
present
review
highlights
the
“OS
hypothesis
AD,”
including
amyloid
beta-peptide-associated
role
protein
oxidation
unraveled
by
proteomics,
antioxidant
strategies
have
been
investigated
modulate
progression
AD.
Collected
studies
from
our
groups
others
contributed
unraveling
close
relationships
between
perturbation
homeostasis
elucidating
redox-regulated
events
potentially
involved
both
pathogenesis
However,
complexity
requires
in-depth
understanding
intracellular
affecting
relevant
for
functions.
This
crucial
developing
pharmacological
targeting
OS-mediated
toxicity
may
contribute
slow
well
improve
quality
life
persons
this
severe
dementing
disorder.
Journal of Toxicology and Environmental Health Part B,
Год журнала:
2023,
Номер
26(5), С. 257 - 274
Опубликована: Март 26, 2023
The
aim
of
this
review
was
to
(i)
acknowledge
structural
advantages
natural
products
(NPs)
for
designing
therapeutic
drugs;
(ii)
emphasize
how
wildlife
conservation
is
socially
and
economically
necessary
scientific
commercial
progress
in
Brazilian
regions;
(iii)
show
decisions
by
governmental
regulations
exert
damaging
effects
on
safeguarding
biodiversity.
Natural
from
animals
(e.g.:
bufadienolides
as
marinobufagin),
plants
(diterpenes:
casearin
X
paclitaxel;
triterpenes:
betulinic
acid)
microorganisms
(depsipeptides:
geodiamolides;
antraciclines:
doxorubicin)
are
the
main
source
oral
drugs
have
innate
enteral
parenteral
drug
design,
synthesis
combinational
chemistry
using
novel
techniques,
including
green
chemistry.
NPs
possess
high
chemical
diversity,
binding
flexibility
biological
targets,
chiral
centers,
aliphatic
systems,
hydrogen-bond
acceptors
donors,
and/or
heteroatoms,
broad-spectrum
pharmacological
properties,
against
malign
disorders.
Nonetheless,
all
biomes
connected
ecosystems
been
systemically
threatened
since
2019
following
fire,
deforestation,
monocultures,
cattle
raising,
mining
oil
spills
mainly
consequence
financial
cuts
key
institutions
which
oversee
environmental
stability
terrestrial
marine
fauna
flora.
Nevertheless,
entities,
broad
traditional
knowledge
agrobiodiversity,
fishing,
fire
management,
pioneering
processes
economic
interest
play
a
vital
role
“Science
Biodiversity,”
arises
business
bioeconomy
opportunities
convert
Brazil
into
self-sufficient
country
production
pharmaceutical
supplies,
cosmeticsand
foods.
Hence,
needs
sustainable
development
projects
supported
government
input
if
one
wishes
use
biodiversity
treat
individuals
improve
quality
life.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD),
are
characterized
by
massive
loss
of
specific
neurons.
It
is
a
progressive
disabling,
severe
and
fatal
complex
disease.
Due
to
its
pathogenesis
limitations
clinical
treatment
strategies,
it
poses
serious
medical
challenge
burden
worldwide.
The
AD
not
clear,
potential
biological
mechanisms
include
aggregation
soluble
amyloid
form
insoluble
plaques,
abnormal
phosphorylation
tau
protein
formation
intracellular
neurofibrillary
tangles
(NFT),
neuroinflammation,
ferroptosis,
oxidative
stress
metal
ion
disorders.
Among
them,
ferroptosis
newly
discovered
programmed
cell
death
induced
iron-dependent
lipid
peroxidation
reactive
oxygen
species.
Recent
studies
have
shown
that
closely
related
AD,
but
the
mechanism
remains
unclear.
may
be
iron
metabolism,
amino
acid
metabolism
affecting
accumulation
ions.
Some
chelating
agents
(deferoxamine,
deferiprone),
chloroiodohydroxyquine
derivatives,
antioxidants
(vitamin
E,
lipoic
acid,
selenium),
derivatives
Fer-1,
tet,
etc.
been
in
animal
effective
exert
neuroprotective
effects.
This
review
summarizes
regulation
natural
plant
products
on
order
provide
reference
information
for
future
research
development
inhibitors.
Frontiers in Aging Neuroscience,
Год журнала:
2022,
Номер
14
Опубликована: Фев. 9, 2022
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
that
eventually
leads
to
dementia
and
death
of
the
patient.
Despite
enormous
amounts
resources
efforts
for
AD
drug
development
during
last
three
decades,
no
effective
treatments
have
been
developed
can
slow
or
halt
progression
disease.
Currently
available
drugs
treating
only
improve
clinical
symptoms
temporarily
with
moderate
efficacies.
In
recent
years,
scientific
community
has
realized
these
challenges
reconsidered
future
directions
development.
The
most
significant
changes
in
strategy
include
shifting
from
amyloid-based
targets
other
targets,
such
as
tau,
toward
better
designs
trials.
However,
still
focused
on
single
mechanism
target,
which
conventional
Although
multifactorial
mechanisms
and,
this
basis,
multi-target
strategies
proposed
approach
not
widely
recognized
accepted
by
mainstream
Here,
we
emphasize
discuss
urgent
need
paradigm
shift
target
multiple
either
multi-target–directed
ligands
combination
therapy
approach.
We
hope
article
will
increase
recognition
nature
promote
shift.
believe
facilitate
successful
therapies.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Июнь 16, 2022
Plants
and
agri-food
by-products
represent
a
wide
renewable
source
of
bioactive
compounds
with
neuroprotective
properties.
In
this
research,
various
green
extraction
techniques
were
employed
to
recover
molecules
from
Kalanchoe
daigremontiana
(kalanchoe),
epicarp
Cyphomandra
betacea
(tamarillo),
cooperage
woods
Robinia
pseudoacacia
(acacia)
Nothofagus
pumilio
(lenga),
as
well
reference
extract
(positive
control)
Rosmarinus
officinalis
L
.
(rosemary).
The
capacity
these
plant
extracts
was
evaluated
in
set
vitro
assays,
including
enzymatic
[acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
lipoxygenase
(LOX)]
antioxidant
[ABTS,
reactive
oxygen
nitrogen
species
(ROS
RNS)]
bioactivity
tests.
Extracts
also
submitted
parallel
artificial
membrane
permeability
assay
mimicking
the
blood–brain
barrier
(PAMPA-BBB)
two
cell
viability
assays
HK-2
SH-SY5Y
lines.
Comprehensive
phytochemical
profiling
based
on
liquid
chromatography
coupled
quadrupole-time-of-flight
mass
spectrometry
(LC-Q-TOF-MS)
analysis
showed
enriched
content
phenolic
terpenoid
target
extracts.
Moreover,
tests
promising
capacity,
particularly
for
supercritical-fluid
(SFE)
acacia
(ABTS
IC
50
=
0.11
μg
ml
−1
;
ROS
1.56
AChE
4.23
BChE
1.20
LOX
4.37
),
whereas
PAMPA-BBB
revealed
high
perfusion
some
representative
compounds,
such
acids
or
flavonoids.
Regarding
cytotoxic
tamarillo
rosemary
SFE
can
be
considered
non-toxic,
lenga
pressurized
(PLE)
mild-cytotoxic,
kalanchoe
highly
toxic
obtained
results
demonstrate
great
potential
studied
biomass
transformed
into
valuable
food
additives,
supplements,
nutraceuticals
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(4), С. 783 - 797
Опубликована: Фев. 6, 2024
The
most
frequent
type
of
age-related
dementia
is
Alzheimer's
disease.
To
discover
novel
therapeutic
agents
for
disease,
a
series
substituted
pyrimidine
derivatives
were
synthesized
and
evaluated
anti-Alzheimer's
activity.
All
the
compounds
validated
by
1HNMR,
13CNMR,
HRMS
to
assess
structural
conformance
newly
compounds.
then
their
in
vivo
acute
toxicity
study.
Evaluation
showed
that
none
up
1000
mg/kg.
After
studies,
subjected
behavioral
biochemical
studies.
Compound
N4-(4-chlorophenyl)-N2-(2-(piperidin-1-yl)ethyl)pyrimidine-2,4-diamine
5b
(SP-2)
displayed
an
excellent
profile,
while
rest
satisfactory
results
comparison
donepezil.
Docking
studies
confirmed
obtained
through
experiments
similar
interaction
Further,
silico
molecular
property
predictions
possesses
favorable
drug-likeness
ADME
properties
CNS
These
implied
could
serve
as
appropriate
lead
molecule
development
agent.
