Nociplastic pain mechanisms and toll-like receptors as promising targets for its management

Pain, Год журнала: 2024, Номер 165(10), С. 2150 - 2164

Опубликована: Апрель 5, 2024

Nociplastic pain, characterized by abnormal pain processing without an identifiable organic cause, affects a significant portion of the global population. Unfortunately, current pharmacological treatments for this condition often prove ineffective, prompting need to explore new potential targets inducing analgesic effects in patients with nociplastic pain. In context, toll-like receptors (TLRs), known their role immune response infections, represent promising opportunities intervention because they play relevant both development and maintenance Although TLRs have been extensively studied neuropathic inflammatory specific contributions remain less clear, demanding further investigation. This review consolidates evidence on connection between focus prevalent conditions like fibromyalgia, stress-induced sleep deprivation-related irritable bowel syndrome. addition, we association psychiatric comorbidities, proposing that modulating can potentially alleviate syndromes related disorders. Finally, discuss sex differences TLR signaling, considering higher prevalence among women. Altogether, aims shed light its underlying mechanisms, intriguing relationship signaling pathways, ultimately framing therapeutic addressing challenging condition.

Язык: Английский

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Cannabidiol reduces neuropathic pain and cognitive impairments through activation of spinal PPARγ

Journal of Pain, Год журнала: 2025, Номер unknown, С. 105378 - 105378

Опубликована: Март 1, 2025

Язык: Английский

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Chronic restraint stress and social transfer of stress produce tactile allodynia mediated by the HMGB1/TNFα/TNFR1 pathway in female and male rats

Physiology & Behavior, Год журнала: 2023, Номер 274, С. 114418 - 114418

Опубликована: Ноя. 30, 2023

Язык: Английский

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Effects of Stress Exposure to Pain Perception in Pre-Clinical Studies: Focus on the Nociceptin/Orphanin FQ–NOP Receptor System

Brain Sciences, Год журнала: 2024, Номер 14(9), С. 936 - 936

Опубликована: Сен. 19, 2024

Exposure to physical and psychological stress modulates pain transmission in a dual manner. Stress-induced analgesia (SIA) refers the reduction sensitivity that can occur response acute stress. On contrary, chronic exposure may lead phenomenon named stress-induced hyperalgesia (SIH). SIH is clinically relevant since it has been well documented exacerbates patients with several syndromes, including migraine. The availability of animal models SIA high importance for understanding biological mechanisms leading these phenomena identification pharmacological targets useful alleviate burden stress-exacerbated pain. Among targets, nociceptin/orphanin FQ (N/OFQ)–N/OFQ peptide (NOP) receptor system identified as key modulator both susceptibility. This review describes first experimental approaches induce rodents. second part manuscript summarizes scientific evidence suggests N/OFQ–NOP player stress–pain interaction candidates NOP antagonists drugs mitigate detrimental effects on perception.

Язык: Английский

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Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 19, 2024

Irritable bowel syndrome (IBS) is a common gastrointestinal disease. Recently, an increasing number of studies have shown that Toll-like receptor 4 (TLR4), widely distributed on the surface variety epithelial cells (ECs) and immune sentinel in gut, plays vital role developing IBS.

Язык: Английский

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