Evodiamine inhibits programmed cell death ligand 1 expression via the PI3K/AKT signaling pathway to regulate antitumor immunity in melanoma DOI Creative Commons
Jiamin Li, Li Jiang, Qing Ma

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

Malignant melanoma, a rare and aggressive skin cancer, arises from the transformation of cutaneous melanocytes is associated with poor prognosis. Evodiamine (EVO), bioactive compound derived traditional Chinese herbal medicine, has demonstrated significant inhibitory effects on various tumor cells. In this study, we aimed to investigate potential EVO in regulating melanoma immunity elucidate its underlying mechanisms. Experimental results revealed that IC50 value B16-F10 cells for 24, 48, 72 h were 11.73, 5.083, 4.604 µM, respectively. inhibited proliferation, invasion, metastasis by more than 50%, while promoting apoptosis higher concentration EVO. also significantly suppressed growth 80% reduced spleen damage tumor-bearing mice. Treatment led marked increase T-cell subsets spleen, bone marrow, tumors, immunohistochemical (IHC) staining particular showing about 50% higher. Furthermore, expression programmed cell death ligand 1 (PD-L1) PI3K/AKT signaling pathway-related proteins both tumors. These findings suggest exerts antitumor enhancing immune microenvironment indicates as therapeutic agent melanoma.

Язык: Английский

A rising star involved in tumour immunity: Lactylation DOI Creative Commons
Xu Zhang, Cong Liang, Chengwei Wu

и другие.

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(20)

Опубликована: Окт. 1, 2024

In recent years, continuous exploration worldwide has revealed that some metabolites produced during cellular and tissue metabolism can act as signalling molecules to exert different effects on the human body. These may cofactors for proteases or post-translational modifications linked proteins. Lactate, a traditional metabolite, is found at high levels in tumour microenvironment (TME). Many studies have shown lactate influences tumorigenesis development via mechanisms, not only through metabolic reprogramming of tumours but also its significant impact immunity. Previously, cells were reported use glucose glutamine fuel metabolism; however, serves an energy source precursor substance needed modification Recent identified novel form epigenetic modification, lactate-mediated histone lysine lactylation (Kla) demonstrated directly stimulates chromatin after gene transcription; consequently, become popular research topic years. This article focuses progress application prospects context

Язык: Английский

Процитировано

3
Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma DOI Creative Commons

Mengmeng Hua,

Tao Li

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

To integrate machine learning and multiomic data on lactylation-related genes (LRGs) for molecular typing prognosis prediction in lung adenocarcinoma (LUAD). LRG mRNA long non-coding RNA transcriptomes, epigenetic methylation data, somatic mutation from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. findings then validated the GSE31210 GSE13213 cohorts. A model was developed identified hub LRGs divide patients into high- low-risk groups. effectiveness of this validated. We two CSs, which Nine LRGs, namely HNRNPC, PPIA, BZW1, GAPDH, H2AFZ, RAN, KIF2C, RACGAP1, WBP11, used construct model. In subsequent validation, high-risk group included more with stage T3 + 4, N1 2 3, M1, III IV cancer; higher recurrence/metastasis rates; lower 1, 5 year overall survival rates. oncogenic pathway analysis, most mutations detected group. tumor microenvironment analysis illustrated that immune activity notably elevated patients, indicating they might strongly respond immunotherapy than patients. Further, oncoPredict revealed have increased sensitivity chemotherapeutics. Overall, we a combines prognosis. Our represent valuable reference further understanding important function modification pathways progression.

Язык: Английский

Процитировано

0
Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives DOI Creative Commons
Hao Yang, Xuefeng Zhang,

Zongming Jia

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Anti-prostate cancer potential of some selected natural alkaloids DOI
Didem Şöhretoğlu, Gülin Renda

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 177 - 196

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Evodiamine inhibits programmed cell death ligand 1 expression via the PI3K/AKT signaling pathway to regulate antitumor immunity in melanoma DOI Creative Commons
Jiamin Li, Li Jiang, Qing Ma

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

Malignant melanoma, a rare and aggressive skin cancer, arises from the transformation of cutaneous melanocytes is associated with poor prognosis. Evodiamine (EVO), bioactive compound derived traditional Chinese herbal medicine, has demonstrated significant inhibitory effects on various tumor cells. In this study, we aimed to investigate potential EVO in regulating melanoma immunity elucidate its underlying mechanisms. Experimental results revealed that IC50 value B16-F10 cells for 24, 48, 72 h were 11.73, 5.083, 4.604 µM, respectively. inhibited proliferation, invasion, metastasis by more than 50%, while promoting apoptosis higher concentration EVO. also significantly suppressed growth 80% reduced spleen damage tumor-bearing mice. Treatment led marked increase T-cell subsets spleen, bone marrow, tumors, immunohistochemical (IHC) staining particular showing about 50% higher. Furthermore, expression programmed cell death ligand 1 (PD-L1) PI3K/AKT signaling pathway-related proteins both tumors. These findings suggest exerts antitumor enhancing immune microenvironment indicates as therapeutic agent melanoma.

Язык: Английский

Процитировано

0