European Journal of Pharmacology, Год журнала: 2024, Номер 969, С. 176452 - 176452
Опубликована: Фев. 28, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 5, 2024
Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.
Язык: Английский
Процитировано
73
Journal of Polymers and the Environment, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Язык: Английский
Процитировано
3
Nanoscale, Год журнала: 2024, Номер 16(8), С. 3881 - 3914
Опубликована: Янв. 1, 2024
The long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression genes and cellular functions in organisms.
Язык: Английский
Процитировано
11
La radiologia medica, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 255, С. 155203 - 155203
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
5
MedComm – Oncology, Год журнала: 2024, Номер 3(1)
Опубликована: Март 1, 2024
Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles SL have expanded beyond definitions encompass biological functions, including genome stability, cell cycle regulation, death mechanisms, cellular metabolism, cell–cell interactions, and microenvironment (TME). Tumor inactivated survival pathways are sensitive therapeutic inhibition compensatory while remain unaffected. Exploiting based on functional contexts potential significantly improve cancer patient reducing resistance targeted enhancing efficacy when combined other treatment modalities. This review explores underlying mechanisms synthetic interactions (SLI) characterized functions in individual TME. We also provide comprehensive summary strategies leveraging dynamic nature SLI overcome resistance. Additionally, we discuss various approaches models screening designing potent agents tailored specific needs patients, as well combining drugs treatment. offers valuable insights into harnessing promising avenue precision therapy.
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133244 - 133244
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8651 - 8651
Опубликована: Авг. 8, 2024
This review highlights significant advancements in antibody–drug conjugates (ADCs) equipped with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods such us maleimide succinimide conjugation classical condensation reactions are prevalent metallodrugs natural compounds. However, emerging non-conventional as photoconjugation gaining traction due to their milder conditions and, an aspect which minimizes side reactions, selective formation of ADC. The also summarizes the therapeutic diagnostic properties these ADCs, highlighting enhanced selectivity reduced effects cancer treatment compared non-conjugated payloads. ADCs combine specificity monoclonal antibodies cytotoxicity chemotherapy drugs, offering a targeted approach elimination cells while sparing healthy tissues. mechanism has demonstrated impressive clinical efficacy various malignancies. Key future include improved linker technology stability controlled release cytotoxic agents, incorporation novel, more potent, identification new cancer-specific antigens through genomic proteomic technologies. expected play crucial role combination therapies immune checkpoint inhibitors, CAR-T cells, small molecule leading durable potentially curative outcomes. Ongoing research trials expanding capabilities, paving way effective, safer, personalized treatments, positioning cornerstone modern medicine hope patients.
Язык: Английский
Процитировано
5
Cancers, Год журнала: 2024, Номер 16(24), С. 4234 - 4234
Опубликована: Дек. 19, 2024
Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness exacerbate negative effects. Metal oxide nanoparticles (MONPs), iron oxide, zinc copper offer promising solution by enhancing targeted drug delivery, reducing systemic toxicity, mitigating chemotherapy-induced disabilities like neurotoxicity cardiotoxicity. Nanocarriers conjugated with drugs can improve delivery within the body enhance their circulation in bloodstream. Recent advancements MONP synthesis functionalization have further improved stability drug-loading capacity, making them valuable tool treatment. MONPs distinctive physicochemical characteristics, enabling better imaging, encapsulation, medication to cancerous cells. These nanocarriers through focused controlled release, off-target effects addressing resistance. This review aims explore potential of efficient for anticancer drugs, limitations traditional chemotherapy poor specificity, Additionally, discusses recent functionalization, stability, compatibility.
Язык: Английский
Процитировано
5
Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123295 - 123295
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
0