Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Spinal
cord
injury
(SCI)
disrupts
gut
flora
and
exacerbates
neuroinflammation.
Evidence
supports
the
important
role
of
intestinal
microbiota
in
SCI.
This
study
evaluated
neuroprotective
effect
Limosilactobacillus
reuteri
(L.
reuteri)
DSM
17938
on
SCI
its
potential
anti-inflammatory
mechanism.
The
was
disorganised
following
SCI,
with
a
significant
decrease
abundance
probiotic
bacteria
such
as
L.
reuteri.
DSM17938
treatment
improved
spinal
pathology
enhanced
locomotor
functional
recovery
SCI-model
rats.
Moreover,
it
modulated
tryptophan
metabolism
by
promoting
indole-3-carboxaldehyde
production.
In
addition,
inhibits
polarization
M1
microglia
reduces
production
IL-6,
IL-1
β,
TNF-α
to
alleviate
It
also
activates
aryl
hydrocarbon
receptor
(AhR)
signalling
via
upregulating
AhR
CYP1A1
expression,
tight
junction
protein
synthesis.
summary,
promotes
modulating
activate
barrier
repair
attenuate
microglial
activation
neuroinflammation,
suggesting
strategy
for
clinical
adjuvant
treatment.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 25, 2025
Edaravone
dexborneol
(Eda-Dex),
a
promising
neuroprotectant
composed
of
edaravone
and
(+)-borneol,
has
been
clinically
applied
in
stroke
treatment.
However,
the
mechanism
action
Eda-Dex
remains
unclear.
A
rat
model
cerebral
ischemia/reperfusion
injury
(CIRI)
was
created
through
middle
artery
occlusion.
Neurological
scoring,
TTC
staining,
laser
speckle
imaging
were
used
to
assess
neurological
deficits,
infarct
size
blood
flow
(CBF).
Behavioral
tests,
including
open
field
test,
elevated
plus
maze,
novel
object
recognition
conducted
animal
behavior.
Western
blotting
ELISA
employed
levels
expression
components
NRF2/ARE
NF-κB/AIM2
pathways
specific
cytokines.
The
oxidative
stress
markers
analyzed
via
commercially
available
kits.
HE
Nissl
immunohistochemistry
pathological
alterations
brain.
dramatically
reduced
deficit
score
size,
increased
CBF,
attenuated
anxiety-like
behavior
improved
cognitive
function
CIRI
rats.
significantly
relieved
inflammatory
response
it
upregulated
NRF2,
NQO1,
HO-1,
SLC7A11
downregulated
NF-κB,
AIM2,
ASC
caspase
1
infarcted
Moreover,
clearly
damage,
rescued
neurons,
activation
microglia
astrocytes.
results
this
study
confirm
that
exerts
neuroprotective
effects
by
synergistically
inhibiting
inflammation
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 803 - 803
Опубликована: Июль 2, 2024
Pregabalin
is
a
medication
primarily
used
in
the
treatment
of
neuropathic
pain
and
anxiety
disorders,
owing
to
its
gabapentinoid
properties.
monotherapy
faces
limitations
due
variable
efficacy
dose-dependent
adverse
reactions.
In
this
study,
we
conducted
comprehensive
investigation
into
potentiation
pregabalin’s
analgesic
effects
by
dexborneol,
neuroprotective
bicyclic
monoterpenoid
compound.
We
performed
animal
experiments
where
models
were
induced
using
two
methods:
peripheral
nerve
injury,
involving
axotomy
ligation
tibial
common
peroneal
nerves,
incisional
through
longitudinal
incision
hind
paw,
while
employing
multifaceted
methodology
that
integrates
behavioral
pharmacology,
molecular
biology,
neuromorphology,
lipidomics
delve
mechanisms
behind
potentiation.
Dexborneol
was
found
enhance
promoting
transportation
central
nervous
system,
disrupting
self-amplifying
vicious
cycles
via
reduction
HMGB1
ATP
release,
exerting
significant
anti-oxidative
modulation
lipid
metabolism.
This
combination
therapy
not
only
boosted
property
but
also
notably
decreased
side
effects.
Moreover,
therapeutic
cocktail
exceeded
basic
relief,
effectively
reducing
neuroinflammation
glial
cell
activation—key
factors
contributing
persistent
chronic
pain.
study
paves
way
for
more
tolerable
effective
options,
highlighting
potential
dexborneol
as
an
adjuvant
pregabalin
therapy.
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Сен. 10, 2024
The
choroid
plexus
(ChP)
helps
maintain
the
homeostasis
of
brain
by
forming
blood-CSF
barrier
via
tight
junctions
(TJ)
at
epithelial
cells,
and
subsequently
preventing
neuroinflammation
restricting
immune
cells
infiltration
into
central
nervous
system.
However,
whether
chronic
cerebral
hypoperfusion
causes
ChP
structural
damage
impairment
remains
understudied.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Chronic
cerebral
hypoperfusion
(CCH)
is
an
important
clinical
condition
characterized
by
a
prolonged
reduction
in
blood
flow
that
contributes
to
several
neurodegenerative
diseases,
including
vascular
dementia
and
Alzheimer’s
disease.
A
number
of
rodent
models
CCH
have
been
developed
mimic
the
human
pathological
conditions
reduced
perfusion.
These
instrumental
elucidating
molecular
cellular
mechanisms
involved
CCH-induced
brain
damage.
Oxidative
stress
induced
perturbations
pathways
caused
CCH,
mitochondrial
dysfunction,
ion
pump
adenosine
triphosphate
(ATP)
depletion.
The
deleterious
leads
accumulation
reactive
oxygen
species
(ROS)
exacerbates
damage
neuronal
structures,
significantly
impairing
cognitive
function.
Among
various
therapeutic
strategies
being
evaluated,
edaravone,
potent
antioxidant,
emerging
as
promising
drug
due
its
neuroprotective
properties
against
oxidative
stress.
Initially
approved
for
use
ischemic
stroke,
research
using
has
shown
edaravone
significant
efficacy
scavenging
free
radicals
ameliorating
stress-induced
under
conditions.
This
mini-review
summarizes
current
literature
on
then
discusses
potential
reduce
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
Background
Ischemic
stroke
(IS)
is
one
of
the
most
common
causes
disability
in
adults
worldwide.
This
study
aimed
to
identify
key
genes
related
inflammatory
response
provide
insights
into
mechanisms
and
management
IS.
Methods
Transcriptomic
data
for
IS
were
downloaded
from
Gene
Expression
Omnibus
(GEO)
database.
Weighted
gene
co-expression
network
analysis
(WGCNA)
differential
expression
used
inflammation-related
(IRGs)
associated
with
Hub
IRGs
screened
using
Lasso,
SVM-RFE,
random
forest
algorithms,
a
nomogram
diagnostic
model
was
constructed.
The
performance
assessed
receiver
operating
characteristic
(ROC)
curves
calibration
plots.
Additionally,
immune
cell
infiltration
potential
small
molecule
drugs
targeting
analyzed.
Results
Nine
differentially
expressed
identified
IS,
including
NMUR1,
AHR,
CD68,
OSM,
CDKN1A,
RGS1,
BTG2,
ATP2C1,
TLR3.
Machine
learning
algorithms
selected
three
hub
(AHR,
NMUR1).
A
based
on
these
showed
excellent
an
area
under
curve
(AUC)
greater
than
0.9
both
training
validation
sets.
Immune
revealed
higher
levels
neutrophils
activated
CD4
+
T
cells,
lower
CD8
NK
naive
B
cells
patients.
exhibited
significant
correlations
infiltration.
Furthermore,
identified,
chrysin,
piperine,
genistein,
resveratrol,
which
have
therapeutic
effects
Conclusion
confirms
impact
progression
provides
new
targets
personalized
treatment
