Multi-stage mechanisms of tumor metastasis and therapeutic strategies
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 11, 2024
The
cascade
of
metastasis
in
tumor
cells,
exhibiting
organ-specific
tendencies,
may
occur
at
numerous
phases
the
disease
and
progress
under
intense
evolutionary
pressures.
Organ-specific
relies
on
formation
pre-metastatic
niche
(PMN),
with
diverse
cell
types
complex
interactions
contributing
to
this
concept,
adding
a
new
dimension
traditional
cascade.
Prior
metastatic
dissemination,
as
orchestrators
PMN
formation,
primary
tumor-derived
extracellular
vesicles
prepare
fertile
microenvironment
for
settlement
colonization
circulating
cells
distant
secondary
sites,
significantly
impacting
cancer
progression
outcomes.
Obviously,
solely
intervening
sites
passively
after
macrometastasis
is
often
insufficient.
Early
prediction
holistic,
macro-level
control
represent
future
directions
therapy.
This
review
emphasizes
dynamic
intricate
systematic
alterations
that
progresses,
illustrates
immunological
landscape
creation,
deepens
understanding
treatment
modalities
pertinent
metastasis,
thereby
identifying
some
prognostic
predictive
biomarkers
favorable
early
predict
occurrence
design
appropriate
combinations.
Язык: Английский
Lung-intestinal axis, Shuangshen granules attenuate lung metastasis by regulating the intestinal microbiota and related metabolites
Phytomedicine,
Год журнала:
2024,
Номер
132, С. 155831 - 155831
Опубликована: Июнь 15, 2024
Based
on
the
proposed
lung-intestinal
axis,
there
is
a
significant
correlation
between
microbiota
and
lung
metastasis.
Targeting
microbial
composition
valuable
in
modulating
host
response
to
cancer
therapeutics.
As
traditional
Chinese
medicine
(TCM)
formula,
Shuangshen
granules
(SSG)
are
clinically
useful
delaying
metastasis,
but
its
underlying
mechanisms
remain
unknown.
Язык: Английский
From ulcerative colitis to metastatic colorectal cancer: The neutrophil contribution
American Journal Of Pathology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment
Journal of Immunology Research,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Colorectal
cancer
(CRC)
stands
as
one
of
the
tumors
with
globally
high
incidence
and
mortality
rates.
In
recent
years,
researchers
have
extensively
explored
role
tumor
immune
microenvironment
(TME)
in
CRC,
highlighting
crucial
influence
cell
populations
driving
progression
shaping
therapeutic
outcomes.
The
TME
encompasses
an
array
cellular
noncellular
constituents,
spanning
cells,
myeloid
tumor-associated
fibroblasts,
among
others.
However,
composition
within
is
highly
dynamic,
evolving
throughout
different
stages
progression.
These
shifts
subpopulation
proportions
lead
to
a
gradual
transition
response,
shifting
from
early
antitumor
growth
late-stage
environment
that
supports
survival.
Therefore,
it
further
investigate
understand
complex
interactions
various
TME.
this
review,
we
explore
key
components
varying
origins,
subpopulations
shared
elements
CRC
TME,
examining
their
interconnections
critical
considerations
for
developing
personalized
precise
immunotherapy
strategies.
Язык: Английский
Imaging and Therapy of Tumors Based on Neutrophil Extracellular Traps
Small Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 21, 2024
Neutrophil
extracellular
traps
(NETs)
formed
by
neutrophils
are
netlike
scaffolds
that
mainly
contain
DNA
and
a
variety
of
granule
proteins.
Many
stimuli
can
lead
to
the
NET
formation
through
independent
molecular
pathways.
Clinically,
abundance
NETs
is
correlated
with
poor
tumor
prognosis.
The
biological
actions
complex
diverse,
including
promoting
progression,
awakening
dormant
cancer
cells,
resulting
in
immunosuppression
support
growth
metastasis.
Therefore,
NET‐associated
pathological
processes
provide
an
important
clue
for
both
diagnostic
imaging
alternative
therapies
many
kinds
cancers.
In
recent
years,
scientists’
efforts
have
focused
on
developing
novel
probes
visualize
therapeutic
strategies
degrading
or
inhibiting
its
block
their
pro‐tumoral
functions.
this
review,
development
evaluation
NETs‐targeted
intervention
progress
therapy
on.
Язык: Английский
Interaction between intratumoral microbiota and neutrophils influences tumor progression
American journal of clinical and experimental immunology.,
Год журнала:
2024,
Номер
13(5), С. 233 - 235
Опубликована: Янв. 1, 2024
In
recent
years,
complex
interactions
between
intratumoral
bacteria
and
neutrophils
have
been
identified
as
significant
factors
in
tumor
occurrence
development.
This
commentary
synthesizes
findings
from
the
past
five
years
to
explore
these
interactions.
It
is
observed
that
during
progression,
promote
neutrophil
infiltration
formation
of
extracellular
traps
(NETs),
which
turn
drive
development
metastasis.
Conversely,
infiltrating
are
also
capable
slowing
progression
by
limiting
number
bacteria.
dual
role
underscores
a
potential
avenue
for
improving
cancer
treatment
outcomes.
Язык: Английский