G9a promotes muscular atrophy in chronic aging and acute denervation DOI Creative Commons
Ying Jin, Wei Kang, Xiaolong Ji

и другие.

Animal Diseases, Год журнала: 2024, Номер 4(1)

Опубликована: Ноя. 5, 2024

Abstract Muscular atrophy accompanied by neuromuscular junction (NMJ) denervation is often observed after long-term chronic diseases and aging associated with substantial morbidity mortality. Here, we report that histone methyltransferase G9a elevated in the muscle of muscular model mice muscle-specific deficiency ( Ehmt2 Ckmm− KO) alleviates both aged denervated mice. Moreover, increased nerve-to-myofiber ratios Agrin-Lrp4-MuSK signaling, which maintains NMJ, are found KO Together, these data suggest promotes disrupts NMJ; thus, inhibiting level may be a potential therapy for atrophy.

Язык: Английский

G9a promotes muscular atrophy in chronic aging and acute denervation DOI Creative Commons
Ying Jin, Wei Kang, Xiaolong Ji

и другие.

Animal Diseases, Год журнала: 2024, Номер 4(1)

Опубликована: Ноя. 5, 2024

Abstract Muscular atrophy accompanied by neuromuscular junction (NMJ) denervation is often observed after long-term chronic diseases and aging associated with substantial morbidity mortality. Here, we report that histone methyltransferase G9a elevated in the muscle of muscular model mice muscle-specific deficiency ( Ehmt2 Ckmm− KO) alleviates both aged denervated mice. Moreover, increased nerve-to-myofiber ratios Agrin-Lrp4-MuSK signaling, which maintains NMJ, are found KO Together, these data suggest promotes disrupts NMJ; thus, inhibiting level may be a potential therapy for atrophy.

Язык: Английский

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