Chitosan/poly (β‐amino ester) hydrogel by controlled release of Centella Asiatica promoted wound healing through improved collagen expression and antibacterial and anti‐inflammatory properties

Polymer Engineering and Science, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Abstract Burn wound healing presents several challenges, including impaired collagen synthesis, delayed closure, and disrupted inflammatory responses. This study investigates the potential of a novel UV‐crosslinked hydrogel made chitosan (CS)/poly(β‐amino ester) (PβAE) Centella Asiatica extract (CA) for second‐degree burn treatment. Among various formulations, monomer ratio 1.5:1 5 wt% 2,2‐dimethoxy‐2‐phenyl‐acetophenone DMPA crosslinker concentration were found optimal. The achieved ~74% controlled release CA over 72 h showed significant enhancement in fibroblast viability (123.66 ± 9% at days). Scratch assay demonstrated ~99.5% closure within 24 h. Collagen type I expression was increased by ~1.7‐fold compared with control. Additionally, exhibited remarkable anti‐inflammatory properties, effectively modulating response. It significantly reduced pro‐inflammatory markers such as IL‐6 TNF‐α while simultaneously enhancing levels cytokines, IL‐10 TGF‐β. dual action not only mitigates inflammation but also fosters regenerative environment, further supporting process promoting tissue recovery. antibacterial properties inhibition zones ~19.1 mm E. coli ~12.4 S. aureus . These results suggest that this biocompatible, biodegradable is promising therapeutic candidate wounds. Highlights Developed chitosan/PβAE burns. Optimized releases Boosts viability, migration, 1.7x. Reduces IL‐6, TNF‐α, IL‐10, Strong against aureus.

Язык: Английский

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Biomedical potential of alginate wound dressings – From preclinical studies to clinical applications: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 142908 - 142908

Опубликована: Апрель 8, 2025

Язык: Английский

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Preparation and characterization of an antibacterial CMC/PCL hydrogel films containing CIP/Cur: In vitro and in vivo evaluation of wound healing activity

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136570 - 136570

Опубликована: Окт. 15, 2024

Язык: Английский

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Sustained release investigation of curcumin and ciprofloxacin on coaxial electrospun nanocomposite scaffold of poly (3-hydroxybutyrate)-poly glycerol sebacate: an approach for skin regeneration

Emergent Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Язык: Английский

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