Effective Action of Silymarin against Ketamine-induced Schizophrenia in Male Mice: Insight into the Biochemical and Molecular Mechanisms of Action

Journal of Psychiatric Research, Год журнала: 2024, Номер 179, С. 141 - 155

Опубликована: Сен. 13, 2024

Язык: Английский

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Alcohol-exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin

Alcohol, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Язык: Английский

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Taurine, an essential amino acid, attenuates rotenone-induced Parkinson’s disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release

Behavioural Brain Research, Год журнала: 2024, Номер 480, С. 115397 - 115397

Опубликована: Дек. 12, 2024

Язык: Английский

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Morin inhibits oxidative stress and inflammation in the cardiorenal system associated with post-traumatic stress and alcohol use disorders in mice

Deleted Journal, Год журнала: 2025, Номер unknown, С. 200196 - 200196

Опубликована: Фев. 1, 2025

Язык: Английский

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Ketamine-Induced Behavioral Perturbations, Redox Imbalances, and Neurotransmitter Deficits in Mice: The Preventive and Reversal Neuromodulatory Potential of Diosmin as an Antipsychotic

Brain Disorders, Год журнала: 2025, Номер unknown, С. 100210 - 100210

Опубликована: Март 1, 2025

Язык: Английский

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Gene-level connections between anxiety disorders, ADHD, and head and neck cancer: insights from a computational biology approach

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Март 20, 2025

Background Anxiety disorders (AD), ADHD, and head neck cancer (HNC) are complex conditions with potential genetic interconnections that remain to be fully elucidated. The purpose of this study is investigate gene-level connections among AD, HNC. Method A comprehensive literature mining approach identified gene-disease relationships from PubMed bioinformatics databases, analyzing 19,924 genes. An AI-driven computational process constructed a relationship table using the Adjusted Binomial Algorithm (ABMA) evaluate association reliability. Overlapping genes were analyzed through protein-protein interaction (PPI) networks, functional annotations, literature-based pathway analyses elucidate shared unique mechanisms linking these diseases. Results analysis 141 significant associated 153 1,065 HNC (q-value < 0.05). These demonstrated overlap (odds ratio ≥ 1.8; p ≤ 2.58E-2) high interconnectivity (PPI network density 0.39, clustering coefficient 0.76, diameter 3). Centrality revealed core such as IL-6, MYC, NLRP3, CXCR4 critical mediators. Functional enrichment key pathways, including serotonergic synapse, inflammatory response, Toll-like receptor signaling, highlighting involvement neuronal immune mechanisms. reciprocal influences HNC, emphasizing distinct may underlie their co-occurrence mutual risk factors. Conclusion This reveals interconnected mechanisms, genes, providing valuable insights into underpinnings avenues for therapeutic exploration.

Язык: Английский

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Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food & Function, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

EA enhanced the abundance of beneficial bacteria as well their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.

Язык: Английский

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