Nitroxidative Stress, Cell—Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2050 - 2050
Опубликована: Фев. 26, 2025
Neuropathic
pain,
a
debilitating
condition
arising
from
somatosensory
system
damage,
significantly
impacts
quality
of
life,
leading
to
anxiety,
self-mutilation,
and
depression.
Oxidative
nitrosative
stress,
an
imbalance
between
reactive
oxygen
nitrogen
species
(ROS/RNS)
antioxidant
defenses,
plays
crucial
role
in
its
pathophysiology.
While
are
essential
for
physiological
functions,
excessive
levels
can
cause
cellular
component
neuronal
dysfunction
pain.
This
review
highlights
the
complex
interactions
species,
systems,
cell
signaling,
neuropathic
We
discuss
roles
ROS/RNS
detrimental
effects
oxidative
stress.
Furthermore,
we
explore
potential
manganese
porphyrins,
compounds
with
properties,
as
promising
therapeutic
agents
mitigate
stress
alleviate
pain
by
targeting
key
pathways
involved
Further
research
is
needed
fully
understand
their
managing
human
non-human
animals.
Язык: Английский
The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Сен. 9, 2024
The
transient
receptor
potential
vanilloid
1
(TRPV1)
channel
plays
a
dual
role
in
peripheral
neuropathic
pain
(NeuP)
by
acting
as
“pain
switch”
through
its
sensitization
and
desensitization.
Hyperalgesia,
commonly
resulting
from
tissue
injury
or
inflammation,
involves
the
of
TRPV1
channels,
which
modulates
sensory
transmission
primary
afferent
nociceptors
to
spinal
dorsal
horn
neurons.
In
chemotherapy-induced
neuropathy
(CIPN),
is
implicated
mechanisms
due
interaction
with
ion
neurotransmitter
signaling,
oxidative
stress.
Sensitization
root
ganglion
neurons
contributes
CIPN
development,
inhibition
channels
can
reduce
mechanical
hypersensitivity.
diabetic
(DPN),
involved
modulation
pathways
including
reactive
oxygen
species
cytokine
production.
TRPV1’s
TRPA1
further
influences
chronic
onset
progression.
Therapeutically,
capsaicin,
agonist,
induce
analgesia
desensitization,
while
antagonists
siRNA
targeting
show
promise
preclinical
studies.
Cannabinoid
provides
another
pathway
for
alleviating
pain.
This
review
summarizes
recent
research
on
association
NeuP.
Язык: Английский
Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
Biological Chemistry,
Год журнала:
2024,
Номер
405(9-10), С. 583 - 599
Опубликована: Сен. 30, 2024
Abstract
Sensory
neurons
serve
to
receive
and
transmit
a
wide
range
of
information
about
the
conditions
world
around
us
as
well
external
internal
state
our
body.
Sensitisation
these
nerve
cells,
i.e.
becoming
more
sensitive
stimuli
or
emergence
intensification
spontaneous
activity,
for
example
in
context
inflammation
injury,
can
lead
chronic
diseases
such
neuropathic
pain.
For
many
disorders
there
are
only
very
limited
treatment
options
order
find
establish
new
therapeutic
approaches,
research
into
exact
causes
sensitisation
with
elucidation
underlying
mechanisms
identification
molecular
components
is
therefore
essential.
These
include
plasma
membrane
receptors
ion
channels
that
involved
signal
reception
transmission.
Members
transient
receptor
potential
(TRP)
channel
family
also
expressed
sensory
some
them
play
crucial
role
temperature
perception.
This
review
article
focuses
on
heat-sensitive
TRPM3
cold-sensitive
TRPM8
(and
TRPA1)
their
importance
dorsal
root
ganglion
discussed
based
studies
related
injury-
chemotherapy-induced
neuropathy.
Язык: Английский