Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging

Vascular Pharmacology, Год журнала: 2025, Номер unknown, С. 107462 - 107462

Опубликована: Янв. 1, 2025

Язык: Английский

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NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue

Biomedicines, Год журнала: 2025, Номер 13(1), С. 224 - 224

Опубликована: Янв. 17, 2025

Background/Objectives: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, impaired contractility. Cellular mechanisms such as senescence, telomere shortening, DNA damage contribute to these processes. Nuclear factor kappa B (NF-κB) has been implicated mediating cellular responses aging tissues, increased NF-κB expression observed hearts of rodents. Therefore, suspected play an important regulatory role molecular processes occurring heart during aging. This study investigates vivo aging-related cardiac alterations, focusing on senescence events. Methods: Young old wild-type (WT) transgenic male mice cardiomyocyte-specific suppression (3M) were used assess function, morphology, markers, lipofuscin deposition, damage, apoptosis. Results: Kaplan–Meier analysis revealed reduced survival 3M compared WT. Echocardiography showed evidence eccentric both diastolic systolic dysfunction mice. Both aged WT exhibited more pronounced hypertrophic cardiomyocytes from Additionally, senescence-associated β-galactosidase activity, p21 protein expression, (marked by phosphorylated H2A.X) elevated young Conclusions: The leads remodeling, dysfunction, process. These findings suggest that plays a critical aging, influencing pathways. implications for development therapeutic strategies aimed at mitigating age-related cardiovascular diseases.

Язык: Английский

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Xanthones explore the mechanism of p53/p21 signaling pathway to prevent cardiac aging and epigenetic regulation of Nrf2 gene

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 131, С. 105759 - 105759

Опубликована: Янв. 13, 2025

Язык: Английский

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Cellular Senescence and Cardiovascular Aging

Опубликована: Янв. 1, 2025

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Transcriptome-Wide Insights: Neonatal Lactose Intolerance Promotes Telomere Damage, Senescence, and Cardiomyopathy in Adult Rat Heart

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1584 - 1584

Опубликована: Фев. 13, 2025

Cardiovascular diseases (CVD) are the primary cause of mortality globally. A significant aspect CVD involves their association with aging and susceptibility to neonatal programming. These factors suggest that adverse conditions during development can disrupt cardiomyocyte differentiation, thereby leading heart dysfunction. This study focuses on long-term effects inflammatory oxidative stress due lactose intolerance (NLI) transcriptome phenotype. Our recent bioinformatic focused toggle genes indicated NLI correlates switch off some in thyroid hormone, calcium, antioxidant signaling pathways, alongside switch-on/off involved DNA damage response inflammation. In presented study, we evaluated ploidy different regions left ventricle (LV), complemented by a transcriptomic analysis quantitative (gradual) difference expression. Cytophotometric morphologic analyses LV cardiomyocytes identified hyperpolyploidy bridges between nuclei suggesting telomere fusion. Transcriptomic profiling highlighted damage, aging, chromatin decompaction, along suppression pathways governing muscle contraction energy metabolism. Echocardiography revealed statistically dilation decrease ejection fraction. The estimation survival rates shortened median lifespan approximately 18% (p < 0.0001) compared control. Altogether, these findings may increase cardiovascular accelerating increased hyperpolyploidization reduced cardiac contractile function. Collectively, our data emphasize importance early identification management metabolic stressors, such as NLI, mitigate risks.

Язык: Английский

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Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0318574 - e0318574

Опубликована: Март 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Язык: Английский

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Genetic predictors of longevity and survival in cellular homeostasis genes: A case-control study

Gene, Год журнала: 2025, Номер 962, С. 149576 - 149576

Опубликована: Май 19, 2025

Язык: Английский

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