Brain Research, Год журнала: 2024, Номер 1848, С. 149327 - 149327
Опубликована: Ноя. 9, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1414 - 1414
Опубликована: Фев. 7, 2025
How to determine suitable animal models of anxiety disorders and post-traumatic stress (PTSD) for screening anxiolytic drugs linking preclinical clinical research is a crucial issue. This review paper provides background knowledge critical determination the discussing this Moreover, article analyzes characteristics, properties, advantages, disadvantages various PTSD. It offers an overview pathophysiology, treatments, prevalence, symptoms in clinics. Furthermore, it comprehensively discusses pharmacological treatments neural mechanisms, as well types properties shaping testing behaviors. In light previous literature discussion, we can understand different functions PTSD help us link research. Animal are used advanced drug discovery programs, specifically psychiatry neuroscience The challenge future will be keep pace with developing appropriate improve translation large datasets obtained
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Фев. 19, 2025
In recent years, high-intensity interval training (HIIT) has gained significant attention due to its efficient use of time. Studies have shown that engaging in regular physical activity can effectively reduce symptoms anxiety. Given the potential side effects and limitations associated with pharmacological treatments for anxiety disorders, there is a growing interest exploring non-pharmacological interventions. HIIT, as an alternative approach, offers promising avenue managing without relying on medication. However, specific efficacy applicability HIIT individuals diagnosed disorders not been systematically summarized literature. This scoping review aims explore effectiveness intervention improving symptoms, well range applicability, by synthesizing existing research. A methodology was employed search databases including PubMed, Web Science, EMbase, Cochrane Library. were selected based predefined criteria: randomized controlled trials (RCTs), cohort studies, quasi-experimental designs focusing improvement anxiety, using primary intervention. Exclusion criteria included studies mixed interventions or populations comorbid conditions. Two independent evaluators screened titles, abstracts, full texts, extracted data pre-tested form, resolved discrepancies through discussion ensure consistency accuracy. total 541 articles identified, which 16 met inclusion this review. The samples comprised various populations, healthy subjects, overweight males, prostate cancer patients, etc. Twelve indicated significantly improves especially lower baseline effect less pronounced those higher Additionally, suggest variations protocols-such frequency, intensity, duration-may influence extent symptoms. study underscores High-Intensity Interval Training effective reducing when tailored individual characteristics. Variations parameters such duration are critical factors optimizing HIIT's mental health benefits.HIIT shows promise valuable tool improve outcomes implemented careful consideration differences protocol variations. provides foundation refining protocols expanding their across diverse populations.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2774 - 2774
Опубликована: Март 19, 2025
Anxiety is a physiological, emotional response that anticipates distal threats. When kept under control, anxiety beneficial response, helping animals to maintain heightened attention in environments with potential dangers. However, an overestimation of threats can lead excessive expression that, humans, may evolve into disorders. Pharmacological treatments show variable efficacy among patients, highlighting the need for more efforts better understand pathogenesis Mounting evidence suggests astrocytes, type glial cells, are active partners neurons brain circuits and regulation behaviors both physiological pathological conditions. In this review, I summarize current literature on role astrocytes from different regions modulating anxious states, goal exploring novel cerebral mechanisms identify innovative therapeutic targets treatment
Язык: Английский
Процитировано
0
Estudios y Perspectivas Revista Científica y Académica, Год журнала: 2025, Номер 5(1), С. 2393 - 2404
Опубликована: Март 22, 2025
A ansiedade é um transtorno mental comum e amplamente prevalente, afetando milhões de pessoas ao redor do mundo. Ela caracterizada por sentimentos persistentes apreensão, nervosismo preocupação excessiva, frequentemente acompanhados sintomas físicos, como taquicardia, sudorese tensão muscular. Esse distúrbio pode comprometer significativamente a qualidade vida, impactando tanto saúde quanto física indivíduo. O tratamento convencional para envolve, em geral, o uso medicamentos ansiolíticos psicoterapias, terapia cognitivo-comportamental. Contudo, essas abordagens podem ter limitações, efeitos colaterais indesejados desafios relacionados à adesão tratamento, que tem levado busca alternativas terapêuticas mais acessíveis eficazes. Nesse contexto, Kaiut Yoga, uma prática focada na mobilidade articular conexão mente-corpo, surgido opção complementar promissora manejo da ansiedade. Este artigo explora os Yoga no dos ansiedade, destacando suas vantagens comparação aos tratamentos convencionais. revisão literatura revela regular yoga ajudar ativar sistema parassimpático, reduzir níveis cortisol melhorar regulação emocional, tornando-se alternativa terapêutica eficaz acessível. demonstrou também potencial aliviar mesmo tempo promove melhora bem-estar geral. As conclusões sugerem essa representa válida com benefícios sustentáveis adaptáveis diferentes perfis, incluindo indivíduos comorbidades limitações físicas. Além ser baixo custo não invasiva, oferece resultados duradouros, relevante aqueles buscam sua vida maneira holística.
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Frontiers in Public Health, Год журнала: 2025, Номер 13
Опубликована: Апрель 10, 2025
Rapid technological progress is reshaping human existence globally. The metaverse, a 3D digital realm merging virtual reality (VR) with physical space, exemplifies this fusion. Users can replicate and customize real-world elements within immersive environment. Over the past decade, VR, augmented (AR), mixed (MR) have become effective tools for addressing mental health conditions, offering solutions to shortage of professionals limited access care. However, extensive participation in gaming social media lead insecurity, anxiety, depression, addictive behaviors, particularly among young adults. This engagement may also impair attention spans, exacerbating symptoms adolescents deficit hyperactivity disorder. research examines impact expanding metaverse applications on health, exploring both risks benefits.
Язык: Английский
Процитировано
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Brain Research, Год журнала: 2024, Номер 1848, С. 149327 - 149327
Опубликована: Ноя. 9, 2024
Язык: Английский
Процитировано
0