Glial Modulator Antibiotics for Neuropathic Pain: Current Insights and Future Directions

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 346 - 346

Опубликована: Фев. 28, 2025

Pathological pain is defined as that outlives its usefulness a protective warning system and becomes debilitating, disrupting normal life function. Understanding the mechanism of transition from physiological to pathological essential provide effective prevention chronic pain. The main subcategories are nociceptive pain, neuropathic nociplastic Glial cells play pivotal roles in development maintenance each these states, specifically Consequently, targeting has emerged promising therapeutic strategy, limited efficacy harmful adverse effects associated with current pharmacotherapies. This paper aims review specific antibiotics modulate glial cells, which can be used treat These include minocycline, doxycycline, ceftriaxone, azithromycin. potential appears promising, particularly given extensive prior research use humans for other illnesses. However, presents own set limitations, ultimately making translation preclinical findings human therapies challenging.

Язык: Английский

Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage

Neurotoxicity Research, Год журнала: 2025, Номер 43(2)

Опубликована: Март 22, 2025

Язык: Английский