Processes,
Год журнала:
2023,
Номер
11(10), С. 2919 - 2919
Опубликована: Окт. 5, 2023
Drug
delivery
systems
(DDS)
are
formulations
or
devices
that
enable
the
introduction
of
a
therapeutic
into
body
and
its
to
target
site,
potentially
enhancing
efficacy
safety.
Advances
in
formulation
approaches
related
enhancement
solubility,
permeability
thus
bioavailability
drugs
have
already
been
successfully
implemented
by
pharmaceutical
industry.
This
review
highlights
importance
formulations/DDS
clinical
development
lifecycle
drug
products.
Examples
from
authorised
products
used
showcase
how
appropriate
could
deliver
site
action
(e.g.,
pulmonary
nasal
delivery)
enhance
patient
adherence
medication
long-acting
injectables,
3D-printed
tablets).
Moreover,
examples
provided
highlight
can
improve
safety
liposomes,
abuse-deterrent
opioid
formulations)
albumin-based
nanoparticles,
permeation
enhancers
for
oral
peptides).
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 124967 - 124967
Опубликована: Ноя. 1, 2024
Many
different
formulation
strategies
have
been
investigated
to
oppose
suboptimal
treatment
of
long-term
or
chronic
conditions,
one
which
are
the
nano-
and
microsuspensions
prepared
as
long-acting
injectables
prolong
release
an
active
pharmaceutical
compound
for
a
defined
period
time
by
regulating
size
particles
milling.
Typically,
surfactant
and/or
polymers
added
in
dispersion
medium
suspension
during
processing
stabilization
purposes.
However,
current
investigations
with
milling
heavily
based
on
prior
expertise
trial-and-error
approaches.
Various
interacting
parameters
such
bead
size,
stabilizer
type
concentration
confounded
investigation
process.
The
present
study
systematically
exploited
statistical
machine
learning
(ML)
understand
relationship
between
characteristics
under
full-factorial
experiments.
Stabilizer
was
identified
significant
factor
(p
<
0.001)
median
diameter
(D
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1495 - 1495
Опубликована: Ноя. 21, 2024
Background/Objectives:
Co-delivering
dual-drug
systems
have
proven
to
be
effective
in,
for
example,
anticancer
therapy
or
HIV
prophylaxis
due
a
higher
target
selectivity
and
therapeutic
efficacy
from
compound
synergism.
However,
various
challenges
regarding
physical
stability
can
arise
during
the
formulation
definition
when
multiple
drug
compounds
are
included
in
same
formulation.
In
this
work,
focus
was
on
aqueous
suspensions,
which
could
applied
as
long-acting
injectable
formulations
release
over
weeks
months
after
administration.
Methods:
It
possible
gain
insights
into
nano-
microsuspensions
containing
two
acidic
(indomethacin
naproxen)
prepared
by
milling
with
dual
centrifugation.
Information
of
individual
suspensions
subtracted
compared
conditions
stored
at
elevated
temperatures
40
°C.
Results:
Distinct
particle
size
profiles
were
obtained
dependent
stabilizer
used
both
suspensions.
Most
notably,
combination
indomethacin
naproxen
one
resulted
smaller
sizes
particles
under
presence
some
stabilizers.
The
further
indicated
that
least
model
needed
sufficiently
stabilized
obtain
physically
stable
28
days
Similarly,
distribution
showed
monomodal
achieved
demonstrated
alone.
Over
28-day
period,
smallest
polysorbate
85
poloxamer
338
only
single
preparation,
indicating
tendencies
towards
stabilization
synergism
stabilizers
well
compounds.
Conclusion:
Overall,
study
preparation
naproxen.
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
205, С. 106980 - 106980
Опубликована: Дек. 4, 2024
The
dual
centrifugation
approach
has
in
the
recent
years
emerged
as
a
powerful
milling
tool
to
prepare
pharmaceutical
suspensions
submicron
range
with
fast-milling
capacity
by
40
samples
simultaneously
2
mL
vials.
While
there
is
some
standardized
conditions
described
literature
when
preparing
aqueous
centrifugation,
more
systematic
and
experimental
understanding
of
process
evaluate
impact
different
variables
centrifuge
on
final
sizes
suspended
drug
particles
independent
compound
used
was
desired.
Overall,
present
study
demonstrated
applicability
for
small-scale
screening
purposes
showed
parameters
physical
attributes
prepared
suspensions.
In
work,
rate
size
reduction
three
model
compounds,
i.e.,
cinnarizine,
haloperidol,
indomethacin,
found
be
mostly
influenced
speed,
beads,
bead
loading
during
milling,
whereas
rotor
temperature
did
not
affect
particle
profiles
stabilized
polysorbate
20
centrifugation.
Smaller
were
general
obtained
at
highest
intensity,
1500
rpm,
smallest
size,
0.2
mm,
higher
loadings
(42
%,
56
83
%).
grinding
limit
approximately
0.50
µm,
0.70
0.35
µm
respectively,
achieved
relatively
fast,
30
min
specified
conditions,
compared
milled
larger
(i.e.,
1.0
mm),
lower
intensities
(e.g.,
1000
rpm),
14
or
28
further
confirmed
that
intensity
necessary
haloperidol
probably
due
compounds
predominantly
plastic
properties.
Sizes
indomethacin
increased
longer
runs
up
240
also
%
%.
These
observations
supported
color
conversion
from
white
yellow
which
indicated
generation
small
quantities
amorphic
material
after
high
intensity.
Upscale
investigations
comparable
all
while
rpm
five
minutes.
Processes,
Год журнала:
2023,
Номер
11(10), С. 2919 - 2919
Опубликована: Окт. 5, 2023
Drug
delivery
systems
(DDS)
are
formulations
or
devices
that
enable
the
introduction
of
a
therapeutic
into
body
and
its
to
target
site,
potentially
enhancing
efficacy
safety.
Advances
in
formulation
approaches
related
enhancement
solubility,
permeability
thus
bioavailability
drugs
have
already
been
successfully
implemented
by
pharmaceutical
industry.
This
review
highlights
importance
formulations/DDS
clinical
development
lifecycle
drug
products.
Examples
from
authorised
products
used
showcase
how
appropriate
could
deliver
site
action
(e.g.,
pulmonary
nasal
delivery)
enhance
patient
adherence
medication
long-acting
injectables,
3D-printed
tablets).
Moreover,
examples
provided
highlight
can
improve
safety
liposomes,
abuse-deterrent
opioid
formulations)
albumin-based
nanoparticles,
permeation
enhancers
for
oral
peptides).
