Chemical Research in Toxicology,
Год журнала:
2024,
Номер
37(10), С. 1601 - 1611
Опубликована: Авг. 8, 2024
With
numerous
novel
and
innovative
in
vitro
models
emerging
every
year
to
reduce
or
replace
animal
testing,
there
is
an
urgent
need
align
the
design,
harmonization,
validation
of
such
systems
using
vitro-in
vivo
extrapolation
(IVIVE)
approaches.
In
particular,
inhalation
toxicology,
a
lack
predictive
prevalidated
lung
that
can
be
considered
valid
alternative
for
testing.
The
power
enhanced
by
applying
Adverse
Outcome
Pathways
(AOP)
framework,
which
casually
links
key
events
(KE)
relevant
IVIVE.
However,
one
difficulties
identified
endpoint
analysis
readouts
specific
assays
toxicants
are
currently
not
harmonized,
making
alignment
challenging.
We
summarize
current
state
art
two
systems,
focusing
on
inflammatory-induced
effects
providing
guidance
future
research
directions
improve
alignment.
