A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
655, С. 124058 - 124058
Опубликована: Март 28, 2024
Язык: Английский
Recent advances in dosage form design for the elderly: a review
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(11), С. 1553 - 1571
Опубликована: Ноя. 2, 2023
Introduction
With
the
increase
in
elderly
population
and
prevalence
of
multiple
medical
conditions,
medication
adherence,
efficacy
have
become
crucial
for
effective
management
their
health.
The
aging
faces
unique
challenges
that
need
to
be
addressed
through
advancements
drug
delivery
systems
formulation
technologies.
Язык: Английский
Investigation of real-life drug intake behaviour in older adults and geriatric patients in Northern Germany – A biopharmaceutical perspective
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
200, С. 106814 - 106814
Опубликована: Май 28, 2024
Dosing
conditions
(type
and
amount
of
accompanying
fluid,
the
type
food,
time
administration,
dosage
form
modifications
such
as
crushing
tablets)
are
critical
affect
performance
oral
forms
in
gastrointestinal
tract
thus
bioavailability.
Because
older
adults
primary
users
medications
more
susceptible
to
adverse
effects,
it
is
important
understand
how
they
take
their
order
reduce
risks
increase
benefits
pharmacotherapy.
The
aim
study
was
investigate
real-life
drug
intake
behaviour
geriatric
patients
discuss
influence
on
absorption
after
administration.
data
from
two
settings
home
vs.
hospital
genders
women
men
were
presented.
A
questionnaire
performed
among
people
aged
at
least
65
years
(hospital
home),
recruited
mostly
community
pharmacies
a
regional
Mecklenburg
-
Western
Pomerania.
obtained
demonstrates
that
same
way
regardless
setting
gender.
There
no
significant
differences.
Interviewed
participants
adherent
doctor's
recommendations
took
every
day.
Medications
most
commonly
taken
with
small
(100
mL)
or
large
(200
glass
noncarbonated
water,
food
(during
breakfast
64
%
intakes
morning
during
dinner
81
evening).
Meal
usually
consisted
bread,
either
jam
honey
(breakfast),
ham
cheese
(dinner).
All
reported
made
tablets.
In
almost
all
cases
splitting
tablet,
which
due
indication.
Язык: Английский
Self-management in Older Adults with Multiple Chronic Conditions (MCCs): A Qualitative Content Analysis
Iranian Journal of Psychiatry and Behavioral Sciences,
Год журнала:
2024,
Номер
18(3)
Опубликована: Авг. 27, 2024
Background:
The
growing
population
of
older
adults
and
the
prevalence
multiple
chronic
conditions
(MCCs)
among
them
present
significant
challenges
in
care
treatment.
Self-management
is
an
effective
approach
to
managing
consequences
MCCs.
Objectives:
This
study
aimed
explore
factors
related
self-management
with
Methods:
qualitative
employed
a
content
analysis
from
June
April
2023
hospitals
universities
Tehran.
sample
consisted
26
participants,
including
MCCs,
family
caregivers,
specialists.
Data
were
collected
through
semi-structured
interviews.
Purposeful
sampling
was
used,
continued
until
data
saturation
achieved.
rigor
evaluated
using
Lincoln
Guba
criteria,
conducted
simultaneously
collection
Elo
Kyngäs
methods.
Results:
final
identified
several
affecting
self-management.
A
total
697
semantic
units
336
codes
categorized
into
13
subcategories
4
main
categories.
These
categories
included:
Individual
(biological
factors,
cognitive
coexisting
diseases,
mental
health,
economic
status,
health-oriented
behaviors),
interpersonal
(interaction
medical
team,
relationships),
health
system
(facilities
centers,
staff
empowerment,
policymaking),
extra-organizational
(cultural
social
factors).
Conclusions:
findings
this
highlight
which
can
be
utilized
design
programs.
Язык: Английский
Formulation, Development, and Characterization of AMB-Based Subcutaneous Implants using PCL and PLGA via Hot-Melt Extrusion
AAPS PharmSciTech,
Год журнала:
2024,
Номер
26(1)
Опубликована: Дек. 17, 2024
Abstract
The
hot-melt
extrusion
process
is
currently
considered
a
prominent
manufacturing
technique
in
the
pharmaceutical
industry.
present
study
intended
to
develop
amlodipine
besylate
(AMB)-loaded
subcutaneous
implants
reduce
frequency
of
administration,
thus
improving
patient
compliance
during
hypertension
management.
AMB
were
prepared
using
continuous
technology
poly(caprolactone)
and
poly(lactic-co-glycolic
acid)
with
dimensions
3.70
cm
(length)
by
2.00
mm
(diameter).
characterized
for
thermal
characteristics,
drug-excipient
incompatibilities,
surface
morphology,
fracturability,
vitro
drug
release,
stability
studies.
Differential
scanning
calorimetry
confirmed
drug's
crystalline
state
within
fabricated
implants,
while
textural
analysis
demonstrated
good
fracturability
lead
formulation.
Scanning
electron
microscopy
revealed
smooth
morphology
implant.
formulation
showed
an
extended
release
profile
over
30
days
(~
2.25
mg
per
day)
followed
zero-order
kinetics
(R
2
value
0.9999)
mean
dissolution
time
14.96
days.
remained
stable
at
accelerated
conditions
40°C
75%
relative
humidity.
In
conclusion,
developing
extruded
could
be
alternative
conventional
(AMB)
Graphical
Язык: Английский
A review of medication errors in overweight and obese patients
Pritha Singha Roy,
Debnath Khottyal,
Dibyendu Jana
и другие.
World Journal of Biology Pharmacy and Health Sciences,
Год журнала:
2023,
Номер
15(1), С. 113 - 130.
Опубликована: Июль 22, 2023
The
increasing
prevalence
of
overweight
and
obesity
has
posed
significant
challenges
in
healthcare,
including
medication
safety.
This
review
paper
aims
to
provide
an
in-depth
analysis
errors
associated
explicitly
with
obese
patients.
report
examines
the
factors
contributing
this
population,
explores
potential
consequences,
suggests
strategies
for
preventing
mitigating
such
errors.
By
addressing
critical
issue,
healthcare
providers
can
enhance
safety
optimise
health
outcomes
individuals.
Язык: Английский