IOP Conference Series Earth and Environmental Science,
Год журнала:
2024,
Номер
1419(1), С. 012021 - 012021
Опубликована: Дек. 1, 2024
Abstract
Amide
bonds
are
prevalent
in
peptides,
synthetic
polymers,
insecticides,
and
pharmaceuticals.
These
play
a
critical
role
medicinal
chemistry
due
to
their
stability,
ability
interact
with
biological
targets,
flexibility
designing
bioactive
compounds.
Many
methods
have
been
devised
date
for
the
synthesis
of
amides,
however
majority
them
rely
on
coupling
agents
an
excess
bases
neutralize
acid
produced
during
reaction.
techniques
low
atom
economy
generate
lot
waste,
making
unfriendly
environment.
Greener
chemical
developed
as
result
growing
worldwide
awareness
environmental
issues
drive
towards
sustainability.
In
this
context,
new
approaches
being
based
concepts
green
sustainable
chemistry,
particularly
through
emerging
research
utilizing
organic
electrosynthesis.
This
review
aims
demonstrate
application
amide
electrosynthesis
pathway
development
future
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1269 - 1269
Опубликована: Окт. 9, 2024
Poly(ADP-ribose)
polymerases
(PARPs)
are
crucial
nuclear
proteins
that
play
important
roles
in
various
cellular
processes,
including
DNA
repair,
gene
transcription,
and
cell
death.
Among
the
17
identified
PARP
family
members,
PARP1
is
most
abundant
enzyme,
with
approximately
1-2
million
molecules
per
cell,
acting
primarily
as
a
damage
sensor.
It
has
become
promising
biological
target
for
anticancer
drug
studies.
Enhanced
expression
present
several
types
of
tumors,
such
melanomas,
lung
cancers,
breast
correlating
low
survival
outcomes
resistance
to
treatment.
inhibitors,
especially
newly
developed
third-generation
inhibitors
currently
undergoing
Phase
II
clinical
trials,
have
shown
efficacy
agents
both
single
drugs
sensitizers
chemo-
radiotherapy.
This
review
explores
properties,
characteristics,
challenges
discussing
their
development
from
first-generation
compounds,
more
sustainable
synthesis
methods
discovery
new
anti-cancer
agents,
mechanisms
therapeutic
action,
potential
targeting
additional
targets
beyond
catalytic
active
site
proteins.
Perspectives
on
green
chemistry
also
discussed.
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
196, С. 106743 - 106743
Опубликована: Март 7, 2024
Environmental
impacts
of
medicines
arise
throughout
their
entire
life
cycle.
The
pharmaceutical
industry
has
a
key
role
in
reducing
these
early
production
phases,
but
currently
limited
possibilities
to
reduce
the
environmental
exposure
arising
from
drug
consumption
and
end-of-life.
aim
this
interview
study
was
explore
current
actions
within
industry,
as
well
views
attitudes
toward
strategies
address
challenges
concerns.
Semi-structured
interviews
were
conducted
among
representatives
(n
=
15)
twelve
companies
operating
Finland
February-May
2021.
data
analyzed
using
qualitative
content
analysis.
overall
aware
multifaceted
related
cycle
pharmaceuticals
improving
sustainability
production.
Improving
waste
management
companies'
own
operations
most
commonly
mentioned
already
taking
place
(15/15).
"Environmental
consumption"
(6/15)
"centralized
manufacturing
countries
with
lax
regulation"
(4/15)
frequently
brought
up
difficult
resolve.
"Development
environmentally
more
sustainable
company"
raised
development
need
(5/15).
To
this,
establishment
tangible
economic
drivers,
regulatory
incentives,
or
reputational
rewards
called
for.
"Incorporation
aspects
into
decision-making
different
situations"
suggested
by
11/15
interviewees
means
promote
development,
e.g.
selection
physicians
consumers.
However,
towards
types
criteria
evaluation
differed
between
interviewees.
Attitudes
"incorporation
fate
assessment
phases
design
development"
mostly
positive
(10/11),
suggesting
that
there
is
keen
interest
foster
introduction
new
tools
enabling
intrinsically
less
harmful
for
environment.
ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(6), С. 1856 - 1870
Опубликована: Май 9, 2024
Antiparasitic
drug
development
stands
as
a
critical
endeavor
in
combating
infectious
diseases
which,
by
affecting
the
well-being
of
humans,
animals,
and
environment,
pose
significant
global
health
challenges.
In
scenario
where
conventional
pharmacological
interventions
have
proven
inadequate,
One
Health
approach,
which
emphasizes
interdisciplinary
collaboration
holistic
solutions,
emerges
vital
strategy.
By
advocating
for
integration
principles
into
R&D
pharmaceutical
pipeline,
this
Perspective
promotes
green
chemistry
methodologies
to
foster
environmentally
friendly
antiparasitic
drugs
both
human
animal
health.
Moreover,
it
highlights
urgent
need
address
vector-borne
parasitic
(VBPDs)
within
context
Health-driven
sustainable
development,
underscoring
pivotal
role
medicinal
chemists
driving
transformative
change.
Aligned
with
Sustainable
Development
Goals
(SDGs)
European
Green
Deal,
explores
application
12
Principles
Chemistry
systematic
framework
guide
discovery
production
efforts
VBPD.
Through
constant
commitment
sustainability,
field
can
overcome
challenges
posed
VBPD
while
promoting
environmental
responsibility.
Serving
call
action,
scientists
are
urged
integrate
concepts
routine
practices,
thereby
paving
way
more
pipeline
drugs.
Drugs and Drug Candidates,
Год журнала:
2025,
Номер
4(1), С. 2 - 2
Опубликована: Янв. 9, 2025
The
Group
for
the
Promotion
of
Pharmaceutical
Chemistry
in
Academia
(GP2A)
held
its
32nd
annual
conference
August
2024
at
University
Coimbra,
Portugal.
There
were
8
keynote
presentations,
12
early
career
researcher
oral
and
34
poster
presentations.
Four
awards
delivered,
two
best
communications
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
In
2015,
the
United
Nations
officially
launched
Sustainable
Development
Goals
(SDGs)
as
"the
blueprint
to
achieve
a
better
and
more
sustainable
future
for
all.
They
address
global
challenges
we
face,
including
those
related
poverty,
inequality,
climate
change,
environmental
degradation,
peace
justice.
The
17
are
all
interconnected,
in
order
leave
no
one
behind,
it
is
important
that
them
by
2030".
Here,
have
embedded
medicinal
chemistry
key
player
SDGs.
We
firmly
believe
can
must
contribute
world
with
an
improved
quality
of
life
taken
critical
look
at
each
SDGs,
dividing
into
Priority
Foundational,
analyzed
how
has
impact
on
them.
Although
much
been
done,
determined
make
progress
this
area.
Processes,
Год журнала:
2025,
Номер
13(4), С. 1034 - 1034
Опубликована: Март 31, 2025
The
extensive
use
of
pharmaceuticals
in
human
and
veterinary
medicine
has
led
to
their
persistent
environmental
release,
posing
ecological
public
health
risks.
Major
sources
include
manufacturing
effluents,
excretion,
aquaculture,
improper
disposal,
contributing
bioaccumulation
ecotoxicity.
Mycoremediation
is
the
fungal-mediated
biodegradation
pharmaceuticals,
offers
a
promising
sustainable
approach
mitigate
pharmaceutical
pollution.
Studies
have
reported
that
certain
fungal
species,
including
Trametes
versicolor
Pleurotus
ostreatus,
can
degrade
up
90%
contaminants,
such
as
diclofenac,
carbamazepine,
ibuprofen,
within
days
weeks,
depending
on
conditions.
Fungi
produce
range
extracellular
enzymes,
laccases
peroxidases,
alongside
intracellular
enzymes
like
cytochrome
P450
monooxygenases,
which
catalyze
transformation
complex
compounds.
These
play
an
essential
role
modifying,
detoxifying,
mineralizing
xenobiotics,
thereby
reducing
persistence
toxicity.
effectiveness
biotransformation
influenced
by
factors
substrate
specificity,
enzyme
stability,
Optimal
degradation
typically
occurs
at
pH
4.5–6.0
temperatures
20–30
°C.
Recent
advancements
engineering,
immobilization
techniques,
bioreactor
design
improved
catalytic
efficiency
process
feasibility.
However,
scaling
fungal-based
remediation
systems
for
large-scale
applications
remains
challenge.
Addressing
these
limitations
with
synthetic
biology,
metabolic
other
biotechnological
innovations
could
further
enhance
enzymatic
pharmaceuticals.
This
review
highlights
innovations,
applications,
challenges
mycoremediation,
emphasizing
potential
fungi
transformative
solution
waste
management.
