PLoS ONE,
Год журнала:
2024,
Номер
19(11), С. e0310319 - e0310319
Опубликована: Ноя. 14, 2024
Tamarix
articulate
from
the
Tamaricaece
family
is
a
halophytic
plant.
This
plant
commonly
called
Athal
or
in
different
Arabic
and
Asian
countries.
Due
to
high
load
of
polyphenolic
phytochemicals,
has
been
used
as
therapeutic
option
against
several
diseases
for
decades.
The
an
anti-inflammatory,
anti-bacterial,
anti-viral,
anti-cancer,
anti-oxidant,
anti-inflammatory.
In
this
work,
222
phytochemical
compounds
T
.
our
previous
study
are
bioinformatic
biophysics
techniques
explore
their
biological
potency
anti-cancer
anti-viral
targets.
By
doing
so,
it
was
found
that
Riddelline
ranked
best
binding
molecule
macromolecules
selected
herein
particular
bacterial
energy
value
compound
KdsA
enzyme
-14.64
kcal/mol,
KdsB
(-13.09
kcal/mol),
MurC
(-13.67
MurD
(-13.54
MurF
(-14.20
Polo-like
kinase
1
(Plk1)
(-12.34
Bcl-2
protein
(-13.39
SARS-CoV-2
main
protease
(-12.67
Human
cell
leukemia
virus
kcal/mol).
mean
Rg
KdsA-Riddelline
complex
KdsA-FPE
32.67
Å,
average
RMSD
2.31
respectively.
complexes
be
dominated
by
van
der
Waals
(-71.98
kcal/mol
-65.09
complex).
lead
also
unveiled
show
favorable
druglike
properties
pharmacokinetics.
Together,
data
suggest
good
anti-bacterial
activities
phytochemicals
thus
can
subjected
experimental
vitro
vivo
investigations.
Advances in logistics, operations, and management science book series,
Год журнала:
2024,
Номер
unknown, С. 319 - 341
Опубликована: Янв. 19, 2024
This
chapter
examines
the
convergence
of
Industry
4.0
and
Pharma
in
context
healthcare
supply
chains.
It
investigates
potential
applications
these
industrial
revolutions
to
enhance
flexibility,
benefits,
challenges,
opportunities
highlights
application
state-of-the-art
technology
create
intelligent,
adaptable,
personalized
chain
systems
for
pharmaceutical
sectors.
The
literature
on
“Pharma
4.0”
is
reviewed,
with
a
focus
sustainable
value
creation
research.
Healthcare
has
some
serious
issues
like
counterfeit
drugs,
non-transparent
chain,
unfear
track
trace
system
medicines
biomedical
instruments.
authors
identified
solutions
help
current
innovative
technologies
practices.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 2, 2024
Inadequate
bioavailability
of
therapeutic
drugs,
which
is
often
the
consequence
their
unacceptable
solubility
and
dissolution
rates,
an
indisputable
operational
challenge
pharmaceutical
companies
due
to
its
detrimental
effect
on
efficacy.
Over
recent
decades,
application
supercritical
fluids
(SCFs)
(mainly
SCCO
2
)
has
attracted
attentions
many
scientists
as
promising
alternative
toxic
environmentally-hazardous
organic
solvents
possessing
positive
advantages
like
low
flammability,
availability,
high
performance,
eco-friendliness
safety/simplicity
operation.
Nowadays,
different
machine
learning
(ML)
a
versatile,
robust
accurate
approach
for
prediction
momentous
parameters
been
great
non-affordability
time-wasting
nature
experimental
investigations.
The
prominent
goal
this
article
review
role
ML-based
tools
solubility/bioavailability
drugs
using
.
Moreover,
importance
factor
in
industry
possible
techniques
increasing
amount
parameter
poorly-soluble
are
comprehensively
discussed.
At
end,
efficiency
improving
manufacturing
process
drug
nanocrystals
aimed
be
IOP Conference Series Earth and Environmental Science,
Год журнала:
2024,
Номер
1419(1), С. 012021 - 012021
Опубликована: Дек. 1, 2024
Abstract
Amide
bonds
are
prevalent
in
peptides,
synthetic
polymers,
insecticides,
and
pharmaceuticals.
These
play
a
critical
role
medicinal
chemistry
due
to
their
stability,
ability
interact
with
biological
targets,
flexibility
designing
bioactive
compounds.
Many
methods
have
been
devised
date
for
the
synthesis
of
amides,
however
majority
them
rely
on
coupling
agents
an
excess
bases
neutralize
acid
produced
during
reaction.
techniques
low
atom
economy
generate
lot
waste,
making
unfriendly
environment.
Greener
chemical
developed
as
result
growing
worldwide
awareness
environmental
issues
drive
towards
sustainability.
In
this
context,
new
approaches
being
based
concepts
green
sustainable
chemistry,
particularly
through
emerging
research
utilizing
organic
electrosynthesis.
This
review
aims
demonstrate
application
amide
electrosynthesis
pathway
development
future
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
99, С. 105929 - 105929
Опубликована: Июль 3, 2024
Concerns
about
environmental
health
are
driving
pharmaceutical
industries
towards
more
eco-friendly
and
biocompatible
products.
Lactobacilli
cell-free
supernatants
(CFS)
mixtures
of
soluble
factors
derived
from
the
microbial
growth
beneficial
bacteria
with
potential
to
serve
as
natural
sustainable
excipients
in
emerging
formulations.
This
work
aims
verify
usefulness
CFS
obtained
human
L.
crispatus
BC5,
gasseri
BC9
BC12
enhancers
nose-to-brain
absorption
small
hydrophilic
molecules.
influence
on
cell
viability
was
investigated
together
their
ability
increase
diffusion
sodium
fluorescein
across
vitro
models
olfactory
epithelium.
The
enhancing
mechanism
studied
through
differential
scanning
calorimetry
analysis
immunostaining
assay
zonula
occludens-1.
use
25
%
(v/v)
all
lactobacilli
porcine
epithelial
primary
cells
not
associated
any
cytotoxic
effect,
but
only
BC5
pointed
out
a
permeation
enhancer
both
biomimetic
membrane
PermeaPad®,
tissue,
model.
seems
rely
perturbation
effect
lipid
membranes
that,
case
cell-based
model,
probably
also
results
an
alteration
tight
junctions'
activity.
PLoS ONE,
Год журнала:
2024,
Номер
19(11), С. e0310319 - e0310319
Опубликована: Ноя. 14, 2024
Tamarix
articulate
from
the
Tamaricaece
family
is
a
halophytic
plant.
This
plant
commonly
called
Athal
or
in
different
Arabic
and
Asian
countries.
Due
to
high
load
of
polyphenolic
phytochemicals,
has
been
used
as
therapeutic
option
against
several
diseases
for
decades.
The
an
anti-inflammatory,
anti-bacterial,
anti-viral,
anti-cancer,
anti-oxidant,
anti-inflammatory.
In
this
work,
222
phytochemical
compounds
T
.
our
previous
study
are
bioinformatic
biophysics
techniques
explore
their
biological
potency
anti-cancer
anti-viral
targets.
By
doing
so,
it
was
found
that
Riddelline
ranked
best
binding
molecule
macromolecules
selected
herein
particular
bacterial
energy
value
compound
KdsA
enzyme
-14.64
kcal/mol,
KdsB
(-13.09
kcal/mol),
MurC
(-13.67
MurD
(-13.54
MurF
(-14.20
Polo-like
kinase
1
(Plk1)
(-12.34
Bcl-2
protein
(-13.39
SARS-CoV-2
main
protease
(-12.67
Human
cell
leukemia
virus
kcal/mol).
mean
Rg
KdsA-Riddelline
complex
KdsA-FPE
32.67
Å,
average
RMSD
2.31
respectively.
complexes
be
dominated
by
van
der
Waals
(-71.98
kcal/mol
-65.09
complex).
lead
also
unveiled
show
favorable
druglike
properties
pharmacokinetics.
Together,
data
suggest
good
anti-bacterial
activities
phytochemicals
thus
can
subjected
experimental
vitro
vivo
investigations.
