Advances in medical polyesters for vascular tissue engineering

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 8, 2024

Abstract Blood vessels are highly dynamic and complex structures with a variety of physiological functions, including the transport oxygen, nutrients, metabolic wastes. Their normal functioning involves close coordinated cooperation cells. However, adverse internal external environmental factors can lead to vascular damage induction various diseases, atherosclerosis thrombosis. This have serious consequences for patients, there is an urgent need innovative techniques repair damaged blood vessels. Polyesters been extensively researched used in treatment disease due their excellent mechanical properties, adjustable biodegradation time, biocompatibility. Given high complexity tissues, it still challenging optimize utilization polyesters repairing Nevertheless, they considerable potential tissue engineering range applications. summary reviews physicochemical properties polyhydroxyalkanoate (PHA), polycaprolactone (PCL), poly-lactic acid (PLA), poly(lactide-co-glycolide) (PLGA), focusing on unique applications engineering. be prepared not only as 3D scaffolds alternative grafts, but also forms such microspheres, fibrous membranes, nanoparticles deliver drugs or bioactive ingredients Finally, anticipated that further developments will occur near future, facilitate wider application these materials

Язык: Английский

---

Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration

Open Life Sciences, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 1, 2024

Abstract Large segmental bone defects are commonly operated with autologous grafting, which has limited sources and poses additional surgical risks. In this study, we fabricated poly(lactide- co -glycolic acid) (PLGA)/β-tricalcium phosphate (β-TCP) composite membranes by electrostatic spinning further promoted osteogenesis regulating the release of β-TCP in hope replacing grafts clinical practice. The addition improved mechanical strength PLGA 2.55 times. Moreover, could accelerate degradation neutralize negative effects acidification microenvironment caused degradation. vitro experiments revealed that PLGA/TCP10 biocompatible released can modulate activity osteoblasts enhancing calcium ions concentration damaged area pH local microenvironment. Simultaneously, an increase moderate lactate content microenvironment, synergistically promoting tube-forming effect human umbilical vein endothelial cells. Therefore, it is potential to utilize PLGA/TCP bioactive at site promote regeneration.

Язык: Английский

---

Supramolecular self-assembling IGF-1 nanofibers modulate neutrophil extracellular traps to accelerate diabetic wound healing

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164259 - 164259

Опубликована: Май 1, 2025

Язык: Английский

---

Crocin facilitates osteogenesis and angiogenesis by moderating oxidative stress and ferroptosis via Nrf2/GPX4 pathway

Tissue and Cell, Год журнала: 2024, Номер unknown, С. 102675 - 102675

Опубликована: Дек. 1, 2024

Язык: Английский

---

Serum insulin-like growth factor-1 as a potential prognostic biomarker for heart failure with reduced ejection fraction: a meta-analysis

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 17, 2024

Background Most studies have indicated that peripheral insulin-like growth levels factor-1 (IGF-1) is valuable in diagnosing heart failure, although the results been inconsistent. To help solve debate, we performed a meta-analysis to explore relationship between IGF-1 and failure (HF). Methods We conducted an extensive search across various databases such as Embase, Cochrane Library, Pubmed, Medline, Web of Science on May 30, 2023. From pool studies, selected 16 relevant articles, encompassing total 1,380 cases 1,153 controls, conduct rigorous meta-analysis. Results The there association lower level HF. random-effects model yielded pooled standardized mean difference (SMD) −0.598 (95% CI: −1.081 −0.116, P = 0.015). Further subgroup analysis also showed were associated with HF age ≥5 years body mass index >1 subgroup. Additionally, significant detected “serum” samples “Europe” subgroups. Importantly, observed patients reduced ejection fraction (HFrEF) compared not preserved (HFpEF). Begg’s Egger’s tests revealed no indication publication bias. Conclusions Our has provided evidence suggesting substantial correlation occurrence prospective are necessary ascertain use reliable biomarker for HF, especially HFrEF. But diagnosis HFpEF should be cautious.

Язык: Английский

---

In-situ Sprayed platelet-derived small extracellular vesicles for the skin flap survival by reducing PANoptosis

Biomaterials, Год журнала: 2024, Номер 316, С. 123001 - 123001

Опубликована: Дек. 6, 2024

Язык: Английский

---