Macroscopic transport models for drugs and vehicles in cancer tissues DOI
Álvaro González‐Garcinuño, Antonio Tabernero, Eva M. Martín del Valle

и другие.

Physical Sciences Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind distribution after administration. In addition, several approaches explored, ranging from pharmacokinetic pharmacodynamic models microscopic transport through macroscopic models. This chapter focuses on latter, models, discusses how these can predict processes involved delivery, free form or vehicle transported. We start by presenting some of differentiating physiological parameters cancer tissues then main equations used for modeling, including fluid flow, mass transport, cell uptake. Also, use dimensionless explaining that control transportation will be examined. Lastly, final section explore process employed building geometries simulate tumors, as well current research being patient-specific simulations made using medical images.

Язык: Английский

Macroscopic transport models for drugs and vehicles in cancer tissues DOI
Álvaro González‐Garcinuño, Antonio Tabernero, Eva M. Martín del Valle

и другие.

Physical Sciences Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind distribution after administration. In addition, several approaches explored, ranging from pharmacokinetic pharmacodynamic models microscopic transport through macroscopic models. This chapter focuses on latter, models, discusses how these can predict processes involved delivery, free form or vehicle transported. We start by presenting some of differentiating physiological parameters cancer tissues then main equations used for modeling, including fluid flow, mass transport, cell uptake. Also, use dimensionless explaining that control transportation will be examined. Lastly, final section explore process employed building geometries simulate tumors, as well current research being patient-specific simulations made using medical images.

Язык: Английский

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