Perivascular Adipose Tissue Density and Stenosis Plaque Degree in Lower Limb Peripheral Arteries in CT DOI Creative Commons

Alice Fortunati,

Chiara Perazzo,

M Basile

и другие.

Journal of Vascular Diseases, Год журнала: 2024, Номер 3(2), С. 224 - 234

Опубликована: Июнь 11, 2024

Background: Perivascular adipose tissue (PVAT) attenuation has emerged as a novel biomarker for identifying high-risk arterial plaques due to its association with inflammation. Recognizing the systemic nature of atherosclerosis and link major cardiovascular events in coronary disease, this study evaluated PVAT peripheral arteries using CT imaging expand understanding diagnostic prognostic potential. Methods: retrospective analysis 53 consecutive patients who underwent angiography, examining density across five primary segments. A 5 mm region interest adjacent vascular wall was analyzed by two blinded readers, reproducibility coefficients calculated determine reliability measurements. For statistical analyses, mean values were derived from these The stratified into four groups based on degree stenosis: <25%, 25–50%, 50–70%, >70%. comparisons between performed Kruskal–Wallis test pairwise Mann–Whitney U Holm–Bonferroni correction multiple comparisons. Results: revealed statistically significant disparities categorically differentiated stenosis (p < 0.001), indicating an severity. This especially pronounced external iliac, common femoral, superficial popliteal arteries, where p-values consistently below 0.05. Subsequent analyses utilizing affirmed findings, particular femoral 0.05). Conclusions: our findings reinforce correlation increased stenosis, supporting clinical value non-invasive risk stratification potentially guiding therapeutic interventions.

Язык: Английский

Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis DOI
Bryan Chong,

Jayanth Jayabaskaran,

Jitesh Ruban

и другие.

Circulation Cardiovascular Imaging, Год журнала: 2023, Номер 16(5)

Опубликована: Май 1, 2023

Epicardial adipose tissue (EAT) has garnered attention as a prognostic and risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates the associations between EAT outcomes stratified across imaging modalities, ethnic groups, study protocols.Medline Embase databases were searched without date restriction on May 2022 articles that examined outcomes. The inclusion criteria (1) studies measuring of adult patients at baseline (2) reporting follow-up data interest. primary outcome was major adverse events. Secondary included cardiac death, myocardial infarction, coronary revascularization, atrial fibrillation.Twenty-nine published 2012 2022, comprising 19 709 patients, in our analysis. Increased thickness volume associated with higher risks death (odds ratio, 2.53 [95% CI, 1.17-5.44]; P=0.020; n=4), infarction 2.63 1.39-4.96]; P=0.003; n=5), revascularization 2.99 1.64-5.44]; P<0.001; fibrillation (adjusted odds 4.04 3.06-5.32]; n=3). For 1 unit increment continuous measure EAT, computed tomography volumetric quantification hazard 1.74 1.42-2.13]; P<0.001) echocardiographic 1.20 1.09-1.32]; conferred an increased events.The utility biomarker predicting prognosticating disease is promising, being identified independent predictors events.URL: https://www.crd.york.ac.uk/prospero; Unique identifier: CRD42022338075.

Язык: Английский

Процитировано

33
Correlation analysis between epicardial adipose tissue and acute coronary syndrome DOI Creative Commons
Zhihong Gao,

Zuo Yuqiang,

Linyi Jia

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

To investigate the correlation between density and volume of epicardial adipose tissue(EAT)and acute coronary syndrome (ACS). This study included 355 subjects (mean age: 60.65 ± 9.67 years; 54.65% male), comprising 175 patients with ACS 180 without ACS. Propensity score matching was applied to balance variables two groups, resulting in 96 successfully matched pairs. Clinical data, tissue (EATV), (EATD) were compared. Independent factors influencing identified using logistic regression analysis, predictive ability each variable evaluated receiver operating characteristic (ROC) curves. Systolic blood pressure, EATV, EATD, fasting glucose, triglycerides, high-sensitivity C-reactive protein significantly elevated group compared non-ACS (all p < 0.05). Spearman analysis revealed a moderate positive EATV BMI (r = 0.444, 0.001), while EATD showed weak negative age -0.177, 0.014) 0.239, 0.001). Univariable demonstrated that both (OR: 2.018, 95% CI: 1.334-3.052) 5.341, 3.293-8.663) associated After adjusting for other risk factors, model confirmed (adjusted OR: 1.892, 95%CI: 1.211-2.955) 6.942, 3.875-12.437) independent predictors (both showing highest value (AUC 0.859). identifies close relationship EAT ACS, highlighting as Among them, stronger than traditional EATV.

Язык: Английский

Процитировано

1
Effect of Vessel Attenuation, VMI Level, and Reconstruction Kernel on Pericoronary Adipose Tissue Attenuation for EID CT and PCD CT: An Ex Vivo Porcine Heart Study DOI

Janique Pitteloud,

Lukas J. Moser,

Konstantin Klambauer

и другие.

American Journal of Roentgenology, Год журнала: 2024, Номер 223(5)

Опубликована: Авг. 21, 2024

Background: Pericoronary adipose tissue (PCAT) attenuation and fat index (FAI) may serve as markers of inflammation risk adverse cardiac events. However, standardization relevant CT acquisition reconstruction parameters is lacking.

Язык: Английский

Процитировано

9
The pericoronary adipose tissue attenuation in CT strongly depends on kernels and iterative reconstructions DOI Creative Commons

Costanza Lisi,

Konstantin Klambauer,

Lukas J. Moser

и другие.

European Radiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

To investigate the influence of kernels and iterative reconstructions on pericoronary adipose tissue (PCAT) attenuation in coronary CT angiography (CCTA).

Язык: Английский

Процитировано

7
Role of epicardial adipose tissue in diabetic cardiomyopathy through the lens of cardiovascular magnetic resonance imaging – a narrative review DOI Creative Commons
Sindhoora Kotha, Sven Plein, John P. Greenwood

и другие.

Therapeutic Advances in Endocrinology and Metabolism, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

Accumulating evidence suggests that ectopic/visceral adiposity may play a key role in the pathogenesis of nonischaemic cardiovascular diseases associated with type 2 diabetes. Epicardial adipose tissue (EAT) is complex visceral fat depot, covering 80% cardiac surface anatomical and functional contiguity to myocardium coronary arteries. EAT interacts biology underlying by secreting wide range adipokines. Magnetic resonance imaging (MRI) reference modality for structural heart. The technique now also emerging as quantification. With this narrative review, we (a) surveyed contemporary clinical studies utilized MRI characterize (studies published 2010–2023); (b) listed trials monitoring response treatment size well myocardial parameters (c) discussed potential pathophysiological development diabetic cardiomyopathy. We concluded increased quantity its inflammatory phenotype correlate early signs left ventricle dysfunction have disease diabetes without artery disease.

Язык: Английский

Процитировано

6
Assessment of epicardial adipose tissue on virtual non-contrast images derived from photon-counting detector coronary CTA datasets DOI Creative Commons
Franka Risch, Florian Schwarz,

Franziska Braun

и другие.

European Radiology, Год журнала: 2022, Номер 33(4), С. 2450 - 2460

Опубликована: Дек. 3, 2022

To assess epicardial adipose tissue (EAT) volume and attenuation of different virtual non-contrast (VNC) reconstructions derived from coronary CTA (CCTA) datasets a photon-counting detector (PCD) CT-system to replace true (TNC) series.Consecutive patients (n = 42) with clinically indicated CCTA TNC were included. Two VNC series reconstructed, using conventional (VNCConv) novel calcium-preserving (VNCPC) algorithm. EAT was segmented on TNC, VNCConv, VNCPC, (CTA-30) thresholds -190 -30 HU an additional segmentation the upper threshold 0 (CTA0). volumes their histograms assessed for each series. Linear regression used correlate Euclidian distance histograms. The paired t-test Wilcoxon signed-rank test differences parametric non-parametric data.EAT showed significant compared (all p < .05), but excellent correlation R2 > 0.9). Measurements VNCPC best (R2 0.99) only minor absolute values. Mean -12%, -3%, -13%, +10% CTA-30, CTA0 TNC. Distribution CT values less difference than VNCConv (mean +7% vs. +2%; Euclidean 0.029 0.016).VNCPC-reconstructions PCD-CCTA can be reliably high accuracy in Substitution would significantly decrease patient's radiation dose.• Measurement are feasible R2>0.9). • Differences algorithms have impact A algorithm enables reliable assessment superior measurements VNC- CCTA-series.

Язык: Английский

Процитировано

20
Relationship between epicardial adipose tissue and coronary atherosclerosis by CCTA in young adults (18–45) DOI Creative Commons

Annalisa Filtz,

Daniel Lorenzatti, Andrea Scotti

и другие.

American Journal of Preventive Cardiology, Год журнала: 2024, Номер 19, С. 100711 - 100711

Опубликована: Июль 20, 2024

Epicardial adipose tissue (EAT) is implicated in the pathogenesis and progression of coronary artery disease (CAD). Limited data exists on interplay between EAT atherosclerosis young individuals. Our study aims to explore relationship CAD a cohort.

Язык: Английский

Процитировано

5
Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation DOI Open Access
Maria Grazia Tarsitano, Carla Pandozzi, Giuseppe Muscogiuri

и другие.

Nutrients, Год журнала: 2022, Номер 14(14), С. 2926 - 2926

Опубликована: Июль 17, 2022

The observation of correlations between obesity and chronic metabolic cardiovascular diseases has led to the emergence strong interests in “adipocyte biology”, particular relation a specific visceral adipose tissue that is epicardial (EAT) its pro-inflammatory role. In recent years, different imaging techniques frequently used daily clinical practice have tried obtain an EAT quantification. We provide useful update on comorbidities related inflammation typical cardiac adiposity, analyzing how assessment could impact data patient prognosis. assessed for eligibility 50 papers, with total 10,458 patients focusing review evaluation two main contexts: diseases. Given peculiar properties rapid responsiveness, act as marker investigate basal risk factor follow-up conditions. future, represent therapeutic target new medications. should become part help clinicians identify at greater developing and/or information their outcomes.

Язык: Английский

Процитировано

18
Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study DOI
Minghui Wang, Le Qin, Wenjun Bao

и другие.

Journal of Endocrinological Investigation, Год журнала: 2024, Номер 47(8), С. 1995 - 2005

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

4
Quality of epicardial adipose tissue predicts major adverse cerebral and cardiovascular events following transcatheter aortic valve implantation DOI

Takaaki Sato,

Kunio Yufu,

Hirochika Yamasaki

и другие.

Heart and Vessels, Год журнала: 2024, Номер 39(7), С. 646 - 653

Опубликована: Март 19, 2024

Язык: Английский

Процитировано

3