Mapping the landscape of biliary tract cancer in Europe: challenges and controversies

The Lancet Regional Health - Europe, Год журнала: 2025, Номер 50, С. 101171 - 101171

Опубликована: Фев. 19, 2025

Biliary tract cancer (BTC) is becoming more common worldwide, with geographic differences in incidence and risk factors. In Europe, BTC may be associated primary sclerosing cholangitis, lithiasis, liver cirrhosis, but frequently observed as a sporadic disease. increasingly affects patients under 60 years, resulting significant social economic burden. Early diagnosis remains challenging due to vague symptoms 50% of BTC, lack specific biomarkers, late presentation poor prognosis. The identification at increased reliable biomarkers require collaborative efforts make faster progress. This Series paper highlights the disparities access diagnostic tools multidisciplinary care particularly economically disadvantaged regions, while identifying priority areas for improvement. Addressing these inequities requires harmonised guidelines, accelerated pathways curative treatments, improved awareness among healthcare professionals public. Multidisciplinary teams (MDTs) are crucial improving patient outcomes, yet inconsistencies exist their implementation not only between different countries, also centres within country. Collaboration standardisation treatment protocols across Europe essential effectively address management BTC.

Язык: Английский

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Cholangiocarcinoma: The Current Status of Surgical Options including Liver Transplantation

Cancers, Год журнала: 2024, Номер 16(11), С. 1946 - 1946

Опубликована: Май 21, 2024

Cholangiocarcinoma (CCA) poses a substantial threat as it ranks the second most prevalent primary liver tumor. The documented annual rise in intrahepatic CCA (iCCA) incidence United States is concerning, indicating its growing impact. Moreover, five-year survival rate after tumor resection only 25%, given that recurrence leading cause of death 53-79% patients. Pre-operative assessments for iCCA focus on pinpointing location, biliary tract involvement, vascular encasements, and metastasis detection. Numerous studies have revealed portal vein embolization (PVE) linked to enhanced rates, improved synthetic functions, decreased overall mortality. challenge achieving clear margins contributes notable iCCA, affecting approximately two-thirds cases within one year, results median less than 12 months recurrent cases. Nearly 50% patients initially considered eligible surgical are ultimately deemed ineligible during exploration. Therefore, staging laparoscopy has been proposed reduce unnecessary laparotomy. Eligibility orthotopic transplantation (OLT) requires certain criteria be granted. OLT offers advantages early-detected unresectable iCCA; can combined with other treatments, such radiofrequency ablation transarterial chemoembolization, specific We aim comprehensively describe strategies available treating CCA, including preoperative measures interventions, alongside current options regarding OLT.

Язык: Английский

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Biliary tract cancer

European Journal of Surgical Oncology, Год журнала: 2024, Номер unknown, С. 108489 - 108489

Опубликована: Июнь 1, 2024

Biliary tract cancers comprise a heterogeneous collection of malignancies usually described as cholangiocarcinoma the intra- or extrahepatic bile duct, including perihilar and gallbladder cancer.

Язык: Английский

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Prognostic Impact of Visceral Adipose Tissue Imaging Parameters in Patients with Cholangiocarcinoma after Surgical Resection

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3939 - 3939

Опубликована: Апрель 1, 2024

Visceral adiposity is known to be related poor prognosis in patients with cholangiocarcinoma; however, the prognostic significance of qualitative features adipose tissue cholangiocarcinoma has yet well defined. This study investigated impact imaging parameters reflecting quantity and characteristics subcutaneous (SAT) visceral (VAT) on recurrence-free survival (RFS) overall (OS) 94 undergoing resection cholangiocarcinoma. The area, mean computed tomography (CT) attenuation, 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake SAT VAT positron emission (PET)/CT for staging work-up were measured, relationship these clinicopathological factors was assessed. TNM stage, histologic grade, lymphovascular invasion, size showed positive correlations parameters. Multivariate analysis demonstrated that visceral-to-subcutaneous area ratio (VSR) (p = 0.024; hazard ratio, 1.718) FDG 0.033; 9.781) significant predictors RFS, but all failed show statistical predicting OS. In addition adiposity, might a promising parameter RFS

Язык: Английский

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ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 4, 2025

Cholangiocarcinoma (CCA), a highly aggressive form of cancer, is known for its high mortality rate. A Disintegrin and Metalloprotease Domain-like Protein Decysin-1 (ADAMDEC1) can promote the development metastasis in various tumors by degrading extracellular matrix. However, regulatory mechanism CCA remains unclear. Public databases clinical tissue samples were used to evaluate whether ADAMDEC1 expression was correlated with prognosis CCA. We investigated ADAMDEC1-related genes proteins assessed biological behaviors cells vitro through functional experiments. Meanwhile, interacting involvement nuclear factor-kappa B (NF-κB) signaling pathway screened verified bioinformatics analysis. The tumorigenicity also xenograft nude mouse model. Our results showed that expressed tumor tissues from patients positively poor prognosis. Interference cell lines targeting successfully constructed. Knockdown or MMP12 both affected cells, silencing inhibited growth vivo. Moreover, interacted MMP12, modulating promoting activation NF-κB pathway. study uncovered patterns roles tissues, highlighting connection Therefore, may serve as potential therapeutic target

Язык: Английский

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Prognostic Significance of Lymph Node Ratio in Intrahepatic and Extrahepatic Cholangiocarcinomas

Cancers, Год журнала: 2025, Номер 17(2), С. 220 - 220

Опубликована: Янв. 11, 2025

Background/Objectives. Lymph Node Ratio (LNR) is increasingly recognized as an important prognostic factor in various cancer types, with the potential to enhance patient stratification for intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinoma. The study aimed assess impact of LNR on survival surgically resected patients ICC ECC. Methods. This was a retrospective analysis National Cancer Database (2004–2020) included ECC (excluding distal bile duct) who underwent primary site resection adequate lymphadenectomy (≥4 LNs excised). Exclusions comprised age < 18 years, distant metastasis, or incomplete key data. calculated ratio positive total examined LNs. Survival probabilities were estimated using Kaplan–Meier Cox regression. Results. inclusion criteria met by 954 1607 In ICC, median OS time 62.7 months LNR0 group, 40.8 30%, 25.2 ≥ 30% (p 0.001). 3-year 69.3%, 54.6%, 34% 0, respectively 0.05). When adjusted age, sex, Charlson–Deyo score, histology, surgical margins, chemo- radiotherapy regression, associated worse (HR 2.1 (95% CI 1.6–2.7) HR 2.94 2.3–3.8)) 1.8–2.5) 3 2.4–3.7)). Conclusions. It well-known that LN-negative have significantly better than LN-positive strongly demonstrates prognosis can be further stratified based it not simply binary factor.

Язык: Английский

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Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 16, 2025

Biliary drainage is then one of the necessary procedures to help patients suffering from icterus reduce serum bilirubin levels and relieve symptoms. The aim this study was identifying risk factors for survival in with cholangiocarcinoma (CCA) treated percutaneous transhepatic biliary (PTBD) develop a simple scoring system predicting PTBD insertion. This single-centre retrospective included 175 consecutive undergoing extrahepatic CCA (perihilar distal). Prognostic affecting were analysed. A multivariate analysis showed that mass forming tumor larger than 5 cm presence metastasis at time served as negative prognostic factor (p = 0.002), better associated lower preprocedural CRP 0.003). Multivariate identified two significant 3-month mortality: mass-forming tumors exceeding 185 µmol/L. developed predict mortality after advanced CCA, demonstrating 86.3% predictive value 43.2% positive value.

Язык: Английский

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Preoperative Blood and CT-Image Nutritional Indicators in Short-Term Outcomes and Machine Learning Survival Framework of Intrahepatic Cholangiocarcinoma

European Journal of Surgical Oncology, Год журнала: 2025, Номер unknown, С. 109654 - 109654

Опубликована: Янв. 1, 2025

Язык: Английский

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Advancements in Locoregional Therapies for Unresectable Intrahepatic Cholangiocarcinoma

Current Oncology, Год журнала: 2025, Номер 32(2), С. 82 - 82

Опубликована: Янв. 31, 2025

Intrahepatic cholangiocarcinoma is an aggressive malignancy with rising incidence and poor outcomes. This review examines recent advancements in locoregional therapies for unresectable intrahepatic cholangiocarcinoma, focusing on external beam radiotherapy, transarterial radioembolization (TARE), hepatic artery infusion pump (HAIP) chemotherapy, liver transplantation. Stereotactic body radiation therapy proton have shown promise achieving local control improving survival. TARE, personalized dosimetry, has demonstrated encouraging results select patient populations. HAIP primarily studied using floxuridine, yielded impressive survival outcomes phase II trials. Liver transplantation, once contraindicated, now being reconsidered carefully selected patients localized disease. While these approaches show potential, randomized controlled trials comparing them to standard systemic are lacking. Patient selection remains crucial, factors such as function, tumor burden, molecular profile influencing treatment decisions. Ongoing research aims optimize sequencing, explore combination strategies therapies, refine phenotype identification criteria. As the landscape of management evolves, a multidisciplinary approach essential tailor improve this challenging

Язык: Английский

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EZH2‐Mediated PHF10 Suppression Amplifies HMGB1/NF‐κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(3)

Опубликована: Фев. 1, 2025

ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most progression CHOL and chemotherapy efficacy. PHF10, one subunit SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis. However, roles PHF10 remains unclear. Here, we utilised bioinformatic analysis reveal lowly samples relative normal tissues. Functionally, demonstrated deficiency enhanced cell proliferation, migration self‐renewal capacities cells. ablation further chemoresistance The transcriptome revealed PHF10‐KO could notably alter several oncogenic crosstalk, NF‐kB signalling. As top hit, HMGB1 mRNA expressions had sharpest increase upon deficiency. coordinated Setdb1 mediate H3K9me3 modifications on promoter suppress its expressions. Low relied promote cells vitro vivo. Furthermore, EZH2 mediated H3K27me3 enrichment region contributes low Lastly, inhibitor (Glycyrrhizin) decreased proliferation rate PHF10‐deleted Targeting rendered re‐sensitive chemotherapy. Collectively, this study functions as tumour suppressor CHOL, is novel target predict overcome chemoresistance.

Язык: Английский

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