Obesity and overweight are associated with worse survival in early-onset colorectal cancer

Surgery, Год журнала: 2024, Номер 176(2), С. 295 - 302

Опубликована: Май 20, 2024

BackgroundObesity and its associated lifestyle are known risk factors for early-onset colorectal cancer with poor postoperative survival outcomes in older patients. We aimed to investigate the impact of obesity on cancers.MethodsRetrospective review all patients undergoing primary resection colon or rectal adenocarcinoma at our institution between 2015–2022. Patients who had palliative resections, resections performed another institution, appendiceal tumors, were underweight excluded. The endpoint was according patient's body mass index: normal weight (18–24.9 kg/m2), overweight (25–29.9 (≥30 kg/m2). Patient tumor characteristics compared three groups.ResultsA total 279 aged <50 years treated hospital; 120 excluded from analysis following reasons: main treatment hospital (n = 97), no resection/palliative 23), index <18 kg/m2 2). Of these, 157 included analysis; 61 (38.9%) 45 (28.7%) obesity. Except a higher frequency hypertension (P .062) obese .001) groups, differences patient observed. Mean overall 89 months weight, 92 overweight, 65 .032). cancer-specific 95 94 68 .018). No statistically significant difference disease-free (75 vs 70 59 months, P .844) seen.ConclusionIndividuals present similar morbidity weight. However, may have detrimental their survival. Addressing as modifiable factor might improve prognosis.

Язык: Английский

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The Importance of Nutrition in Cancer Care: A Narrative Review

Current Nutrition Reports, Год журнала: 2024, Номер unknown

Опубликована: Сен. 15, 2024

Язык: Английский

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Malnutrition risk screening in adult oncology outpatients: An ASPEN systematic review and clinical recommendations

Journal of Parenteral and Enteral Nutrition, Год журнала: 2024, Номер 48(8), С. 874 - 894

Опубликована: Окт. 16, 2024

Abstract Background Malnutrition screening is not widely practiced in outpatient cancer centers. This review aims to determine the validity of malnutrition tools and provide recommendations for clinical use. Methods Studies identified by a systematic assessed general adult oncology outpatients from five databases through 2022. The American Society Parenteral Enteral Nutrition (ASPEN) convened working group members Academy Dietetics, Oncology Nurse Patient Navigators, Cancer Society, Clinical Oncology, Nutrition, Radiation Association Care Centers, Nursing answer following questions: (1) should clinicians screen malnutrition, (2) which are recommended, (3) what applications risk outpatients? Results Twenty 738 studies met criteria were reviewed. Six with specific cut‐points demonstrated including Mini Nutritional Assessment (≤23.5), Screening Tool (MST; MST ≥ 2 patient‐led 2), Universal (MUST; MUST 1 Risk Screening‐2002 (NRS‐2002; NRS‐2002 3), NUTRISCORE 5, Patient‐Generated Subjective Global Short Form (PG‐SGA SF; PG‐SGA SF 7 8). Conclusion valid identification ambulatory settings recommended before treatment initiation regularly thereafter, depending on course. Research needed understand extent early diagnosis management improves care patients.

Язык: Английский

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High Geriatric Nutritional Risk Index Risk as a Predictor of Postoperative Complications and Early Mortality in Older Adult Patients Undergoing Pancreatoduodenectomy for Periampullary Malignancies

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 655 - 655

Опубликована: Янв. 20, 2025

Introduction: Pancreaticoduodenectomy (PD) is a major surgery associated with significant morbidity and mortality, especially in older adult patients. Malnutrition common complication these patients linked to poorer outcomes. This study aimed investigate the associations between preoperative nutritional status using Geriatric Nutritional Risk Index (GNRI) postoperative outcomes who underwent PD. Methods: A retrospective cohort was conducted on 363 The GNRI calculated based serum albumin levels body mass index. ≤ 82, 83 ≤98, > 98 were classified as severely malnourished, moderately/mildly no malnourishment, respectively. Perioperative data, including demographics, comorbidities, complications, collected. Univariate multivariate analyses performed assess such length of hospital stay, overall survival. Results: Patients higher more likely experience Clavien–Dindo grade ≥ 3b complications (42.1% vs. 22.0% 14.1%; p = 0.027) pulmonary (26.3% 11.9% 4.2%; 0.016). These also stayed at for longer duration (17.0% 16.0% 11.0%; < 0.001). Multivariate analysis confirmed that an independent predictor adverse outcomes, even after adjusting other confounding factors. Conclusions: Our findings highlight importance assessment undergoing low scores are increased risk prolonged recovery. results underscore need targeted interventions regular monitoring Future studies should focus improve

Язык: Английский

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Toward a Pragmatic Multidisciplinary Management of Nutritional Risk in Hospitalized Patients: Initiatives and Proposals of the Clinical Nutrition Network of Lombardy Region

Nutrients, Год журнала: 2025, Номер 17(9), С. 1472 - 1472

Опубликована: Апрель 27, 2025

Malnutrition is a widespread problem in hospitalized patients, which significantly impacts clinical outcomes, quality of life, and healthcare costs. Despite its well-documented consequences, it remains underdiagnosed inadequately managed many settings. Even with recent progress, key challenges remain, including inconsistent use standardized nutritional screening tools practices, insufficient professional training, resource limitations. A multidisciplinary approach involving physicians, dietitians, nurses, pharmacists crucial for early detection, timely intervention, prevention malnutrition-related complications. The sustainability model requires overcoming logistical financial barriers, the integration technology real-time monitoring, protocols, specific training. Regional initiatives, such as establishment Clinical Nutrition Network Lombardy (Italy), reported discussed this article, have made strides improving care by promoting scientific networking practices across hospitals. This may not only improve patient outcomes but also reduce long-term costs shortening hospital stays preventing readmissions. For to be effective sustainable, collaboration among providers, policymakers, researchers essential promote an integrated, cost-effective managing risk throughout continuum care.

Язык: Английский

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Optimisation of the patient having oncological surgical through prehabilitation: a narrative review

Anaesthesia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Summary Introduction Prehabilitation aims to improve physiological reserve and psychological resilience, enabling patients better tolerate the stress of major surgery, thereby reducing risk complications improving surgical outcomes. In this review, we provide an update development prehabilitation in having cancer surgery. Methods We searched databases peer‐reviewed research identify appropriate papers. Keywords comprised ‘prehabilitation’, ‘cancer surgery’ associated synonyms (prehab; pre‐operative rehabilitation; cancer). The results were combined with articles identified by reviewing references key papers use grey literature develop our discussion. Results detail different elements (exercise, nutrition, support) relevant undergoing focusing on recent evidence base ongoing challenges. Within this, consider role behaviour change undertake interventions reflect models that have been utilised. Facilitators barriers implementation are explored. Key findings include positioning as integral part oncological pathway which includes, but is discrete from, medical optimisation. Discussion has potential outcomes for Further needed understand how what optimal exercise, nutrition their care, long‐term lifestyle using methodology. Digital technology offers opportunity scaling greater personalisation needs be deliberately fashioned ensure equitable access.

Язык: Английский

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Near-Death Quality of Life in Cancer Patients on Home Parenteral Nutrition

Nutrients, Год журнала: 2025, Номер 17(2), С. 271 - 271

Опубликована: Янв. 13, 2025

Background: The impact of home parenteral nutrition (HPN) on the quality life (QoL) cancer patients has been previously investigated. However, scarce data are available regarding near-death QoL in with receiving HPN. This study aims to investigate changes these last two months before death. Methods: is a secondary analysis previous, prospective, longitudinal, observational study. was assessed using EORTC QLQ-C30 questionnaire. Results: Eighty-four adult who died HPN and had filled out questionnaire between 31 60 days (M2) within 30 prior (M1) death were included this analysis. questionnaires at M2 M1 compared those by same start (T0). At M2, there significant improvement both global symptoms scales (p < 0.001 p 0.033, respectively), while M1, scale persisted 0.035) T0. Conclusions: Our first reports that HPN, if started early according European guidelines, associated an even

Язык: Английский

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Nutritional Status and Information Provided to Polish Cancer Patients Assessed Using the EORTC QLQ-INFO25 Questionnaire

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(3), С. 697 - 697

Опубликована: Янв. 22, 2025

Background/Objectives: Malnutrition in cancer patients may significantly affect various aspects of the quality life, outcomes, and prognosis, while satisfaction with information provided also influence these aspects. This study aims to assess nutritional status Polish its association level received, their potential need for more information, resultant life. Methods: A cross-sectional was conducted 104 patients. Validated European Organization Research Treatment Cancer questionnaires EORTC QLQ-C30 QLQ-INFO25 were used, assessment using Subjective Global Assessment (SGA). Results: Male reported receiving than females about disease, treatment, care options, as well greater satisfaction, a higher overall score. Patients enteral nutrition satisfied compared those not it, even if scores obtained within specific areas did differ, but they still wished receive information. Older younger patients, indicating received regarding medical tests satisfaction. The global score showed strong or moderate positive correlations majority modules, influenced Conclusions: Female nutrition, young less which negatively Effective communication highlights personalized informational support enhance

Язык: Английский

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Comparison between patients who have undergone cancer surgery based on MST value: a retrospective study.

Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria, Год журнала: 2025, Номер 45(1)

Опубликована: Фев. 3, 2025

Abstract Introduction: Malnutrition is a prevalent concern in oncologic surgery patients, often exacerbated by the effects of cancer and its treatments. associated with poor clinical outcomes, including higher mortality rates, longer hospital stays, increased complications. The Screening Tool (MST) valuable method for identifying malnutrition risk at admission. This study aims to assess prevalence using MST evaluate prognostic value relation such as length stay (LOS), inflammatory markers, patients. Methods: A retrospective cohort was conducted Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia, from January 2022 2024. Nutritional status assessed MST, key outcomes—LOS, markers (Neutrophil-to-Lymphocyte Ratio [NLR]), serum albumin, total lymphocyte count (TLC), Prognostic Index (PNI)—were analyzed. Statistical comparisons were performed chi-square tests t-tests, statistical significance set p < 0.05. Results: Among 284 33.8% classified malnourished (MST ≥2). Patients scores had significantly worse (33.3% vs. 12.3% <2, 0.001). Malnourished patients exhibited poorer nutritional NLR (6.13 4.68, = 0.05), lower albumin (3.0 g/dL 3.3 g/dL, 0.004), PNI (36.4 41.8, No significant difference found LOS between two groups (median 10 days 9 days, 0.732). Conclusion: Malnutrition, identified strongly worsened These findings underscore need routine screening timely interventions improve outcomes this high-risk population.

Язык: Английский

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Effect of Hemoglobin, Albumin, Lymphocyte Count, and Platelet (HALP) Score on Survival of Patients with Metastatic Thyroid Cancer Treated with Tyrosine Kinase Inhibitors

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1306 - 1306

Опубликована: Фев. 16, 2025

Tyrosine kinase inhibitors (TKIs) are crucial for improving the survival rates of individuals with metastatic thyroid cancer. Moreover, systemic inflammation and malnutrition known to negatively affect cancer prognosis. Evaluating nutritional status at start treatment can improve rates. Purpose: This study investigated correlation between hemoglobin, albumin, lymphocyte count, platelet (HALP) score prognosis patients undergoing first-line TKI therapy. Methods: We retrospectively analyzed data from 44 January 2010 June 2024. The primary outcomes evaluated in were time failure (TTF) overall (OS); HALP scores categorized as low (≤29.21) high (>29.21) based on receiver operating characteristic analysis. Results: 1-year rate was significantly lower group compared (50% vs. 96.3%). Multivariate Cox regression analysis revealed that scores, elevated leukocyte counts, lymphopenia independent predictors shorter TTF (HR = 0.272, p 0.011) OS 0.208, 0.028). Conclusions: results obtained present demonstrate has prognostic significance who treatment. In patients, interventions focused start, during initiation, throughout may enhance effectiveness. However, further prospective studies involving larger patient cohorts necessary validate our results.

Язык: Английский

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