Опубликована: Янв. 1, 2024
Язык: Английский
Cancers, Год журнала: 2024, Номер 16(5), С. 920 - 920
Опубликована: Фев. 25, 2024
Purpose: This study was designed to elucidate the various new classifications and use of LDLT bridging therapy for HCC in this context beyond Milan criteria (MC). Methods: The clinical data patients with outside MC who underwent LT at Jena University between January 2007 August 2023 were retrospectively analysed. Eligible classified according classification systems. Clinicopathological features, overall disease-free survival rates compared within therapy. Results: Among 245 analysed, 120 did not meet MC, 125 met MC. Moreover, there comparable versus (OS 44.3 months vs. 28.3 months; 5-year survival, 56.4% 40%; p = 0.84). G3 tumour differentiation, presence angioinvasion lack statistically significant risk factors recurrence univariate multivariate analyses (HR 6.34; 0.0002; HR 8.21; < 0.0001; 7.50; 0.0001). Bridging before transplantation provided a advantage regardless transplant procedure (OS: 0.008; DFS: 0.001). Conclusions: Patients or had worse outcomes those but still without transplantation. Nevertheless, such remain disadvantaged on waiting list, which is why represents safe alternative should be considered bridged because differences size marker dynamics.
Язык: Английский
Процитировано
1
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(3), С. 1947 - 1964
Опубликована: Июль 10, 2024
Язык: Английский
Процитировано
1
Sports Medicine and Health Science, Год журнала: 2024, Номер 7(2), С. 143 - 156
Опубликована: Март 22, 2024
The integration of exercise prescriptions into cancer adjuvant therapy presents challenges stemming from the ambiguity surrounding precise mechanism through which intervention mitigates risk hepatocellular carcinoma (HCC) mortality and recurrence. Elucidation this specific has substantial social clinical implications. In study, tumor-bearing mice engaged in voluntary wheel running exhibited a notable decrease tumor growth, exceeding 30%. Microarray analysis revealed an upregulation cytokine-related pathways as potential explanation for effect. inclusion granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to enhance cell proliferation, while absence GM-CSF resulted marked inhibition growth. findings suggest that exercise-induced serum can impede proliferation mouse cells, with adipokine chemerin inhibiting growth GM-CSF. Additionally, stimulate secretion by brown adipose tissue. Chemerin suppression led reduction proliferation. results study may release adipokines tissue, transport them blood distant microenvironment, downregulate expression, alleviating immunosuppression thereby at HCC progression. These provide theoretical basis incorporating prescription treatment.
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Окт. 14, 2024
Background In recent years, studies have confirmed the predictive capability of spectral computer tomography (CT) in determining microvascular invasion (MVI) patients with hepatocellular carcinoma (HCC). Discrepancies predicted MVI values between conventional CT imaging features and parameters necessitate additional validation. Methods this retrospective study, 105 cases small HCC were reviewed, participants divided into MVI-negative (n=53, Male:48 (90.57%); mean age, 59.40 ± 11.79 years) MVI-positive (n=52, Male:50(96.15%); 58.74 9.21 groups using pathological results. Imaging iodine density (ID) obtained from three-phase enhancement scans gathered all participants. The study evaluated differences ID two groups, assessing their diagnostic accuracy predicting occurrence patients. Furthermore, efficacy was compared. Results Significant noted presence mosaic architecture, nodule-in-nodule corona p-values < 0.001. There also notable disparities IDs across arterial phase, portal delayed phases, enhancement, nonsmooth tumor margin demonstrate significant efficacy, area under curve (AUC) 0.761, 0.742, 0.752, respectively. analysis, arterial, portal, phase exhibit remarkable detecting MVI, AUCs 0.821, 0.832, 0.802, combined models features, ID, reveal substantial capabilities, 0.846, 0.872, 0.904, DeLong test results indicated no statistically IDs. Conclusions Substantial study. exhibited a robust precision MVI. Additionally, our suggest that both showed similar for
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0