Preliminary Study by Differential Scanning Calorimetric Analysis of Red Blood Cells in Peripheral Artery Disease Patients Treated with Cilostazol: Correlation with Improvements in Walking Distance

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 60 - 60

Опубликована: Янв. 7, 2025

Objective: Peripheral artery disease (PAD) is a prevalent vascular condition characterized by arterial narrowing, which impairs blood flow and manifests as intermittent claudication, pain or cramping sensation induced physical activity ambulation. Walking distance crucial clinical indicator of peripheral disease, it correlates with the severity risk mortality. It reflects reduced mobility indicating an increased morbidity. can also inform on efficacy treatment. Cilostazol, phosphodiesterase III inhibitor, has been demonstrated to enhance walking in patients through dilation vessels inhibition platelet aggregation. With this preliminary study, we aimed elucidate other possible effects cilostazol, specifically its influence structural properties red cells. Methods: 10 (5 men, 5 women) PAD were treated cilostazol over three-month period. Its biochemical RBCs determined using differential scanning calorimetry (DSC). Patient's samples collected at start treatment, then after two weeks, one month, months, three months therapy. Results: The DSC analysis revealed shifts thermal properties, including change peak (melting denaturation) temperature (Tp) calorimetric enthalpy (ΔHcal), indicate significant changes These property correlated improvements reported patients. Conclusions: Our findings suggest that induces substantial modifications cells, enhancing their functional contributing improved outcomes. This study highlights potential adjunctive method for assessing effectiveness treatments cellular level. However, further investigation larger patient cohorts required confirm these initial results.

Язык: Английский

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Burden of Lower Extremity Peripheral Artery Disease, Along with its Associated Risk Factors, Globally and in Five Distinct Social Development Index Regions from 1990 to 2021, with Future Projections of Disease Risk for 2045

Опубликована: Янв. 1, 2025

Background: Lower extremity peripheral artery disease (PAD) is caused by atherosclerosis, which impacts the arteries responsible for supplying blood to lower extremities. In patients with PAD, vessel lumen becomes narrow, resulting in flow limitations, thrombosis, and a range of complications. At present, recognition PAD still at relatively low level. this study, we utilized data from Global Burden Disease Study Database spanning 1990 2021 compute various metrics, including incidence, prevalence, mortality, disability-adjusted life years, attributable risk factors, estimate annual percentage changes (EAPC). The EAPC serves as metric evaluating temporal trends.Methods: analysis was stratified age, sex, sociodemographic index (SDI), geographic region. Joinpoint regression employed examine trends age-standardized incidence rates (ASIRs), prevalence rates, mortality year both globally across five distinct SDI regions.Findings: on rise regions. ASIR increasing some High fasting plasma glucose emerged most significant factor contributing burden. expected stabilize 2045 after minor increase.Interpretation: A better understanding can facilitate development targeted response measures healthcare policies. Additionally, projected burden enable timely interventions reducing impact disease.Funding: This study did not receive any funding.Declaration Interest: authors declare that they have no known competing financial interests or personal relationships could appeared influence work reported article.Ethical Approval: received an exemption Institutional Review Board (IRB) it publicly accessible contain confidential personally identifiable information.

Язык: Английский

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Analysis of burden and equality of lower extremity peripheral artery disease in people aged 40 and above in the Belt and Road partner countries from 1990 to 2021

Journal of Zhejiang University (Medical Sciences), Год журнала: 2025, Номер 54(1), С. 10 - 20

Опубликована: Янв. 1, 2025

To analyze the disease burden and inequalities of lower extremity peripheral artery disorders (LEPAD) among people aged 40 above in Belt Road partner countries from 1990 to 2021. Data were retrieved Global Burden Disease 2021 database. The age-standardized prevalence rates, mortality annual rate years lived with disability (YLDs) LEPAD analyzed. Trends measured using estimated percentage change (EAPC), slope index inequality (SII) concentration used quantify absolute relative inequalities. In 2021, rates 3168.26/105 3.09/105, increasing by 4.30% 19.31% compared 1990, YLDs decreased 4.00%. Females had higher while males rates. EAPC for was slightly (0.22%) than females (0.17%); 2.02% females, 1.45% males. From 16.23/105 15.58/105, a faster decline (－0.12%) (－0.06%). varied across countries, burdens Europe growth Gulf states. Higher socio-demographic prevalence. Inequity improved, SII at 52.90/105 0.038 Gender disparities persisted, rising 0.058 falling －0.026 risen, Significant differences exist peoples different gender highlighting need enhanced screening, health education, shared public strategies countries.

Язык: Английский

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FUNDAMENTALS OF WOUND CARE FOR AMPUTATION PREVENTION

Seminars in Vascular Surgery, Год журнала: 2025, Номер 38(1), С. 54 - 63

Опубликована: Янв. 18, 2025

The initial skin breakdown and subsequent healing processes are complex influenced by various parameters, including systemic factors, infectious bioburden, perfusion. Vascular wounds comprise inadequate inflow (due to peripheral artery disease), microvascular damage (result of diabetes mellitus), or vasoconstriction. Normal acute occurs in a sequence defined stages; however, if dysregulated inflammatory state ensues, it is classified as chronic. Both chronic vascular carry an increased risk amputation. Therefore, holistic wound care crucial preventing limb loss. This review outlines systematic approach assessment examines the latest recommendations for managing wounds, focusing on strategies amputations.

Язык: Английский

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Comparison of Endovascular Interventions for the Treatment of Superficial Femoral Artery Disease: A Network Meta-analysis

Journal of the Society for Cardiovascular Angiography & Interventions, Год журнала: 2025, Номер 4(1), С. 102432 - 102432

Опубликована: Янв. 1, 2025

Язык: Английский

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Single-centre, double-blinded, randomised placebo-controlled trial to determine the effect of a 12-week home-based programme of footplate neuromuscular electrical stimulation on walking capacity in people with peripheral artery disease: a protocol for the Foot-PAD trial

BMJ Open, Год журнала: 2025, Номер 15(1), С. e093162 - e093162

Опубликована: Янв. 1, 2025

Introduction Patients with peripheral artery disease (PAD) can experience intermittent claudication, which limits walking capacity and the ability to undertake daily activities. While exercise therapy is an established way improve in people PAD, it not feasible all patients. Neuromuscular electrical stimulation (NMES) provides a passively induce repeated muscle contractions has been widely used as for chronic conditions that limit functional capacity. Preliminary trials patients PAD demonstrate of leg muscles using footplate-NMES device be performed without pain may lead significant gains Studies, date, have small adequately controlled account any potential placebo effect. Therefore, current trial will compare effect 12-week programme placebo-control on (6 min distance) other secondary outcomes PAD. Methods analysis The Foot-PAD double-blinded, randomised placebo-controlled determine home-based footplate NMES This single-centre numerous recruitment locations. A total 180 participants stable claudication randomly assigned (1:1 ratio) receive either (intervention condition) or footplate-placebo (control two 30 periods each day 12 weeks. deliver sufficient contraction plantar dorsiflexion at ankles. momentary low-intensity transient insufficient muscles. Outcomes assessed baseline (week 0), mid-intervention 6), postintervention 12) 6 weeks after completion intervention 18). primary outcome week 12, measured maximum distance during walk test. Secondary include pain-free test; time graded treadmill disease-specific quality life (Intermittent Claudication Questionnaire), self-reported impairment (Walking Impairment Questionnaire) accelerometer-derived physical activity levels. Exploratory Ankle-Brachial Index; vascular function; perception device-use symptom monitoring throughout Symptom Instrument Visual Analogue Scale. Ethics dissemination received ethics approval from Human Research Committees Queensland Health Metro North Hospital Service (78962) University Sunshine Coast (A21659). Regardless study outcomes, findings published peer-reviewed scientific journals presented meetings. Trial registration number ACTRN12621001383853.

Язык: Английский

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Benefits of Duplex Ultrasound Surveillance of infra-inguinal bypass grafts and institutional costs of graft failure: a retrospective single-centre study.

Annals of Vascular Surgery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Long-Term Results of Treatment of Aortoiliac Occlusive Disease With the Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) Technique: A UK Multicenter Study

Journal of Endovascular Therapy, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Objective: This updated UK multicenter study aims to report long-term results following use of the Covered Endovascular Reconstruction Aortic Bifurcation (CERAB) technique for treating aortoiliac occlusive disease (AIOD) in patients with chronic limb-threatening ischemia (CLTI) or intermittent claudication (IC). Methods: A retrospective analysis was conducted including 85 who underwent CERAB between November 1, 2012, and March 31, 2020, till 2024. Anatomical data were assessed using pre-operative imaging. Outcome measures included freedom from target lesion reintervention (fTLR), major limb amputation (fMLA), overall survival. Results: The median age 65 years, 62.4% males. Over a follow-up 58.2 months (IQR 55.7–67.1 months), 2 lost follow-up. There 16 deaths (18.8%) amputations (2.4%) entire period. Target required 14 (16.5%) at last Kaplan-Meier fTLR 3, 5 years 89.2%, 83.0%, respectively. fMLA 98% all intervals, survival rates 94.1%, 89.4%, 80.1%, Subintimal iliac access associated worse (HR 4.33 (95% CI 1.30–14.37, p=0.017)), which remained significant when adjusted patient anatomical characteristics 5.88 1.02–33.95, p=0.047)). no association need common femoral endarterectomy 3.57 0.42–30.5, p=0.244)] external artery stenting 0.47 0.07–3.05, p=0.427)) during index procedure. Conclusion: outcomes AIOD demonstrate its viability as durable revascularization option, acceptable morbidity, mortality, patency rates. Factors reflecting more complex lesions are poorer outcomes. Findings support randomized controlled trials on focus pre- intra-operative decision-making based complexity TASC C D lesions. Clinical Impact findings this reinforce durability (AIOD), demonstrating favourable salvage These viable alternative open surgery, particularly anatomies comorbidities. enables clinicians make informed decisions regarding selection procedural strategies, such minimising subintimal improve underscores further randomised establish CERAB’s role evidence-based clinical guidelines management.

Язык: Английский

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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from the ARMEX trial

Journal of Patient-Reported Outcomes, Год журнала: 2025, Номер 9(1)

Опубликована: Фев. 7, 2025

Peripheral artery disease (PAD) negatively affects walking performance, health-related quality of life (HRQoL) and mental health. Exercise training is recommended as a first-line treatment for PAD, with potential impact on all these outcomes, but the optimal program design not completely ascertained. The aim this study was to compare arm-ergometry (AEx) treadmill supervised exercise (TEx) HRQoL health in patients PAD. This an ancillary ARMEX trial, single-center, single-blinded, parallel group, randomized clinical enrolling symptomatic PAD referred cardiovascular rehabilitation (CRP). Participants were (1:1) 12-week AEx or TEx, along core components CRP (nutritional psychological support). completed short form 36 Health Survey Hospital Anxiety Depression scale before after intervention. Differences between groups change from baseline end analyzed using ANCOVA, adjusted values, Mann-Whitney U test. Fifty-six (66 ± 8.4 years; 87.5% male) included: (n = 28) TEx 28). Physical functioning, role-physical, bodily-pain, general health, physical component summary (PCS) significantly improved group. In vitality, social role-emotional PCS improved. Role-physical more no between-group differences other domains. Changes associated changes distances. scores both groups, without differences. improvement self-reported distance. Both protocols highlighting exercise-based programs important strategies population. ISRCTN54908548 (retrospectively registered).

Язык: Английский

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Großer Zeh – kleines Übel?

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

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