Autophagy and Mitophagy in Diabetic Kidney Disease—A Literature Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 806 - 806

Опубликована: Янв. 18, 2025

Autophagy and mitophagy are critical cellular processes that maintain homeostasis by removing damaged organelles promoting survival under stress conditions. In the context of diabetic kidney disease, these mechanisms play essential roles in mitigating damage. This review provides an in-depth analysis recent literature on relationship between autophagy, mitophagy, highlighting current state knowledge, existing research gaps, potential areas for future investigations. Diabetic nephropathy (DN) is traditionally defined as a specific form disease caused long-standing diabetes, characterized classic histological lesions kidney, including mesangial expansion, glomerular basement membrane thickening, nodular glomerulosclerosis (Kimmelstiel–Wilson nodules), podocyte injury. Clinical markers DN albuminuria gradual decline filtration rate (GFR). (DKD) broader more inclusive term, all forms chronic (CKD) individuals with regardless underlying pathology. includes patients who may have diabetes-associated damage without typical findings nephropathy. It also accounts other coexisting diseases (e.g., hypertensive nephrosclerosis, ischemic nephropathy, tubulointerstitial nephropathies), even absence albuminuria, such reduction GFR.

Язык: Английский

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Predictive value of the triglyceride-glucose index for coronary artery bypass grafting-acute kidney injury patients

BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Март 21, 2025

Acute kidney injury (AKI) is a common and serious complication after coronary artery bypass grafting (CABG), significantly affecting patient outcomes. The triglyceride-glucose (TyG) index, marker of insulin resistance, has shown potential in predicting various metabolic cardiovascular conditions. This study aimed to evaluate the predictive value TyG index for AKI occurrence following CABG. retrospective, single-center included 3,260 patients who underwent Patients were categorized into non-AKI groups based on postoperative renal function. preoperative was calculated from fasting blood glucose triglyceride levels. further divided quartiles index. Logistic regression analysis used assess relationship between risk. Subgroup analyses spline employed explore interactions non-linear relationships. Of patients, 514 (15.8%) developed AKI. Baseline characteristics showed that had higher levels hemoglobin (Hb), alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), glucose, while brain natriuretic peptide (BNP) lower compared patients. confirmed an independent risk factor CABG, both as continuous variable (OR 1.034 [95% CI 1.017–1.050], p < 0.001) when grouped by quartiles. A observed, with significant increase exceeded 5.4. revealed this association consistent across multiple groups, including those stratified age, sex, BMI, extracorporeal circulation use, comorbidities such hypertension, diabetes, hyperlipidemia. predictor dose-response observed subgroups. Monitoring can help identify high-risk potentially guiding early intervention improving These findings underscore valuable tool clinical practice, warranting validation prospective studies.

Язык: Английский

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Identification of Spatial Specific Lipid Metabolic Signatures in Long-Standing Diabetic Kidney Disease

Metabolites, Год журнала: 2024, Номер 14(11), С. 641 - 641

Опубликована: Ноя. 20, 2024

Diabetic kidney disease (DKD) is a major complication of diabetes leading to failure.

Язык: Английский

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Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment

Kidney International Reports, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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