Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
469, С. 133935 - 133935
Опубликована: Март 1, 2024
Bisphenol
A
(BPA)
and
its
various
forms
used
as
BPA
alternatives
in
industries
are
recognized
toxic
compounds
antiandrogenic
endocrine
disruptors.
These
chemicals
widespread
the
environment
frequently
detected
biological
samples.
Concerns
exist
about
their
impact
on
hormones,
disrupting
natural
processes
humans,
together
with
negative
impacts
biotic
life.
This
study
aims
to
characterize
interaction
between
analogs
androgen
receptor
(AR)
effect
receptor's
normal
activity.
To
achieve
this
goal,
molecular
docking
was
conducted
dihydrotestosterone
(DHT)
a
reference
ligand.
Four
exhibited
higher
affinity
(−10.2
−8.7
kcal/mol)
for
AR
compared
(−8.6
kcal/mol),
displaying
distinct
patterns.
Interestingly,
DHT
(−11.0
shared
binding
pattern
BPA.
ADMET
analysis
of
top
10
compounds,
followed
by
dynamics
simulations,
revealed
toxicity
dynamic
behavior.
Experimental
studies
demonstrated
that
only
disrupts
DHT-induced
dimerization,
thereby
affecting
AR's
function
due
nature.
similarity
observed
during
computational
analysis.
findings
emphasize
importance
targeted
strategies
mitigate
toxicity,
offering
crucial
insights
interventions
human
health
environmental
well-being.
Язык: Английский
Mechanisms of toxicity caused by bisphenol analogs in human in vitro cell models
Chemico-Biological Interactions,
Год журнала:
2025,
Номер
unknown, С. 111475 - 111475
Опубликована: Март 1, 2025
Язык: Английский
Cytotoxic Impacts of Seven Alternative Bisphenols on Human In Vitro Cellular Models
Chemosphere,
Год журнала:
2024,
Номер
366, С. 143408 - 143408
Опубликована: Сен. 24, 2024
Язык: Английский
Vascular Toxicity of Endocrine Disruptors: A Thinly Veiled Threat
Advances in biochemistry in health and disease,
Год журнала:
2024,
Номер
unknown, С. 209 - 232
Опубликована: Янв. 1, 2024
Язык: Английский
In silico analysis of endocrine‐disrupting potential of triclosan, bisphenol A, and their analogs and derivatives
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
44(12), С. 1897 - 1913
Опубликована: Авг. 11, 2024
Owning
to
the
increasing
body
of
evidence
about
ubiquitous
exposure
endocrine
disruptors
(EDCs),
particularly
bisphenol
A
(BPA),
and
associated
health
effects,
BPA
has
been
gradually
substituted
with
insufficiently
tested
structural
analogs.
The
unmanaged
excessive
use
antimicrobial
agents
such
as
triclosan
(TCS)
during
COVID-19
outbreak
also
raised
concerns
its
possible
interferences
hormonal
functions.
similarity
estradiol,
well
TCS
non-steroidal
estrogens,
imply
that
endocrine-disrupting
properties
their
analogs
could
be
predicted
based
on
chemical
structure.
Hence,
this
study
aimed
evaluate
potential
substitutes
derivatives
degradation/biotransformation
metabolites,
in
comparison
molecular
properties,
computational
predictions
pharmacokinetics
binding
affinities
nuclear
receptors.
Based
obtained
results
several
under-researched
exhibited
higher
for
receptors
than
BPA.
Notable
included
compounds
detected
receipts
(DD-70,
BTUM-70,
TGSA,
BisOPP-A),
along
a
flame
retardant,
BDP.
hazards
linked
mono-hydroxylated
metabolites
were
found.
Further
research
is
needed
order
elucidate
impacts
these
promote
better
regulation
practices.
Язык: Английский
Impact of bisphenol a on the levels of vascular calcification biomarkers in type 2 diabetes mellitus with vascular complications: A case-control study
Mohanraj Nehru,
Prasanth Subramaniam,
M.S. Jancy
и другие.
Emerging contaminants,
Год журнала:
2024,
Номер
10(4), С. 100342 - 100342
Опубликована: Апрель 16, 2024
Bisphenol
A
(BPA)
is
an
endocrine
disruptor
present
in
polycarbonate
plastics
used
food
containers
and
water
bottles
that
resists
insulin
action
leads
to
type
2
diabetes
mellitus
(T2DM).
However,
there
scant
research
on
the
impact
of
BPA
T2DM-related
vascular
complications.
Fetuin-A
(FTA)
osteoprotegerin
(OPG)
are
crucial
markers
for
calcification,
which
primary
risk
factor
developing
This
study
aims
link
external
levels
with
calcification
FTA
OPG
diabetic
subjects
without
Therefore,
120
were
included
divided
as
control
(n
=
30),
T2DM
cardiovascular
diseases
(CVD)
nephropathy
(DN)
complications
30).
Serum
urinary
FTA,
OPG,
measured
using
ELISA.
(AHSG)
(TNFRSF11B)
gene
expression
analyzed
qPCR.
Both
serum
(p
<
0.001)
found
higher
CVD
DN
than
control.
Also,
patients
had
lower
protein
increased
Moreover,
was
negatively
associated
0.01).
Likewise,
positively
significant
0.01)
groups.
These
findings
suggest
elevated
blood
contribute
severity
through
calcification.
Язык: Английский